The Value of Desmethylclozapine and Serum CRP in Clozapine Toxicity: A Case Report
Clozapine, an atypical antipsychotic, has proved to be superior to other antipsychotics in treating patients with refractory schizophrenia. An increased plasma clozapine level above the therapeutic window may be associated with serious adverse events including paralytic ileus. Clozapine toxicity may...
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Language: | English |
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Wiley
2012-01-01
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Series: | Case Reports in Psychiatry |
Online Access: | http://dx.doi.org/10.1155/2012/592784 |
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author | Khalid Abou Farha Andre van Vliet Henderikus Knegtering Richard Bruggeman |
author_facet | Khalid Abou Farha Andre van Vliet Henderikus Knegtering Richard Bruggeman |
author_sort | Khalid Abou Farha |
collection | DOAJ |
description | Clozapine, an atypical antipsychotic, has proved to be superior to other antipsychotics in treating patients with refractory schizophrenia. An increased plasma clozapine level above the therapeutic window may be associated with serious adverse events including paralytic ileus. Clozapine toxicity may occur in association with infection or after drug overdose. In a medical emergency situation, differentiating between a toxic clozapine ingestion and an infection-induced toxicity might be hindered by associated CNS changes and by the clozapine modulation of the inflammatory process. This may delay prompt initiation of a tailored treatment strategy. Here, we report a case of paralytic ileus developed within the context of clozapine toxicity. Although the underlying cause of toxicity was not clinically obvious, giving antimicrobial therapy resulted in an improvement in the patient’s clinical condition. This report indicates the value of serum levels of C-reactive protein and desmethylclozapine, major metabolite of clozapine, in the treatment of aetiologically unclear clozapine toxicity. |
format | Article |
id | doaj-art-74ee80c070024b7480ec827f8ddb1003 |
institution | Kabale University |
issn | 2090-682X 2090-6838 |
language | English |
publishDate | 2012-01-01 |
publisher | Wiley |
record_format | Article |
series | Case Reports in Psychiatry |
spelling | doaj-art-74ee80c070024b7480ec827f8ddb10032025-02-03T01:11:28ZengWileyCase Reports in Psychiatry2090-682X2090-68382012-01-01201210.1155/2012/592784592784The Value of Desmethylclozapine and Serum CRP in Clozapine Toxicity: A Case ReportKhalid Abou Farha0Andre van Vliet1Henderikus Knegtering2Richard Bruggeman3QPS Netherlands B.V. 9713 GZ Groningen, The NetherlandsPRA International, 9471 GP Zuidlaren, The NetherlandsLentis Mental Health Organisation, 9725 AG Groningen, The NetherlandsRob Giel Onderzoekscentrum, Department of Psychiatry, University Medical Centre Groningen, University of Groningen, 9700 RB Groningen, The NetherlandsClozapine, an atypical antipsychotic, has proved to be superior to other antipsychotics in treating patients with refractory schizophrenia. An increased plasma clozapine level above the therapeutic window may be associated with serious adverse events including paralytic ileus. Clozapine toxicity may occur in association with infection or after drug overdose. In a medical emergency situation, differentiating between a toxic clozapine ingestion and an infection-induced toxicity might be hindered by associated CNS changes and by the clozapine modulation of the inflammatory process. This may delay prompt initiation of a tailored treatment strategy. Here, we report a case of paralytic ileus developed within the context of clozapine toxicity. Although the underlying cause of toxicity was not clinically obvious, giving antimicrobial therapy resulted in an improvement in the patient’s clinical condition. This report indicates the value of serum levels of C-reactive protein and desmethylclozapine, major metabolite of clozapine, in the treatment of aetiologically unclear clozapine toxicity.http://dx.doi.org/10.1155/2012/592784 |
spellingShingle | Khalid Abou Farha Andre van Vliet Henderikus Knegtering Richard Bruggeman The Value of Desmethylclozapine and Serum CRP in Clozapine Toxicity: A Case Report Case Reports in Psychiatry |
title | The Value of Desmethylclozapine and Serum CRP in Clozapine Toxicity: A Case Report |
title_full | The Value of Desmethylclozapine and Serum CRP in Clozapine Toxicity: A Case Report |
title_fullStr | The Value of Desmethylclozapine and Serum CRP in Clozapine Toxicity: A Case Report |
title_full_unstemmed | The Value of Desmethylclozapine and Serum CRP in Clozapine Toxicity: A Case Report |
title_short | The Value of Desmethylclozapine and Serum CRP in Clozapine Toxicity: A Case Report |
title_sort | value of desmethylclozapine and serum crp in clozapine toxicity a case report |
url | http://dx.doi.org/10.1155/2012/592784 |
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