Fibroblast growth factor receptor 3 mutation promotes HSPB6-mediated cuproptosis in hypochondroplasia by impairing chondrocyte autophagy

Fibroblast growth factor receptor 3 mutation promotes HSPB6-mediated cuproptosis in hypochondroplasia by impairing chondrocyte autophagy

Background: Hypochondroplasia (HCH) is a prevalent form of dwarfism linked to mutations in the fibroblast growth factor receptor 3 (FGFR3) gene, causing missense alterations. We previous report was the first to identify FGFR3(G382D) gain-of-function variants with a positive family history as a novel...

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Bibliographic Details
Main Authors: Jing Chen, Dan He, Chengrun Yuan, Na Li, Baohong Shi, Conway Niu, Jiangfei Yang, Liangkai Zheng, Lin Che, Ren Xu
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Journal of Orthopaedic Translation
Subjects:
Autophagy
Cuproptosis
Fibroblast growth factor receptor 3
Heat shock protein B 6
mitochondrial fission
Hypochondroplasia
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X25000129
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