Beta cells intrinsically sense and limit their secretory activity via mTORC1-RhoA signaling

Beta cells intrinsically sense and limit their secretory activity via mTORC1-RhoA signaling

Summary: Precise regulation of insulin secretion by pancreatic β cells is essential to prevent excessive insulin release. Here, we show that the nutrient sensor mechanistic Target of Rapamycin Complex 1 (mTORC1) is rapidly activated by glucose in β cells via the insulin secretion machinery, position...

Full description

Saved in:
Bibliographic Details
Main Authors: Saar Krell, Amit Hamburg, Ofer Gover, Kfir Molakandov, Gil Leibowitz, Kfir Sharabi, Michael D. Walker, Aharon Helman
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Cell Reports
Subjects:
CP: Metabolism
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725004188
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items