Structural and biochemical differences between non-catalytic and catalytic antibodies

Structural and biochemical differences between non-catalytic and catalytic antibodies

A conventional antibody can be converted into its catalytic counterparts by deleting Pro95 in the CDR-3 of human and mice antibody light chains, as previously reported. T99wt is a naturally occurring human antibody light chain that we transformed into its catalytic antibody using Pro95 deletion. In...

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Bibliographic Details
Main Authors: Taizo Uda, Ryuichi Kato, Yasuteru Shigeta, Shun Hirota, Jun Kobayashi, Hisashi Yoshida, Masato Tsuyuguchi, Kowit Hengphasatporn, Moe Tsujita, Hiroaki Taguchi, Emi Hifumi
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:mAbs
Subjects:
Catalytic antibody
pro95 residue deletion
amyloid-beta
tau-protein
X-ray crystallography
molecular dynamics
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2025.2503978
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https://www.tandfonline.com/doi/10.1080/19420862.2025.2503978

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