Sex-specific influences of APOEε4 genotype on hippocampal neurogenesis and progenitor cells in middle-aged rats

Sex-specific influences of APOEε4 genotype on hippocampal neurogenesis and progenitor cells in middle-aged rats

Summary Female sex and Apolipoprotein (APOE) ε4 genotype are top risk factors for late-onset Alzheimer’s disease. This research investigates how these two risk factors might interact to influence biomarkers of brain health at middle age using a rat model. Compared to healthy controls, male rats with...

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Bibliographic Details
Main Authors:	Bonnie H. Lee, Melike Cevizci, Stephanie E. Lieblich, Liisa A. M. Galea
Format:	Article
Language:	English
Published:	BMC 2025-02-01
Series:	Biology of Sex Differences
Subjects:	Sex differences Alzheimer’s disease Hippocampus Microglia Male Female
Online Access:	https://doi.org/10.1186/s13293-025-00694-8
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