Longitudinal Changes of Axial Length and Associated Factors in Congenital Ectopia Lentis Patients
Purpose. To investigate the longitudinal changes and associated factors of axial length (AL) in congenital ectopia lentis (CEL) patients. Methods. In this retrospective study, medical records of CEL patients were reviewed from January 2014 to December 2019 at the Zhongshan Ophthalmic (ZOC) in China....
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2022/4032283 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832554939027554304 |
|---|---|
| author | Jingxin He Zhangkai Lian Qianzhong Cao Zhenzhen Liu Charlotte Aimee Young Xinyu Zhang Danying Zheng Guangming Jin |
| author_facet | Jingxin He Zhangkai Lian Qianzhong Cao Zhenzhen Liu Charlotte Aimee Young Xinyu Zhang Danying Zheng Guangming Jin |
| author_sort | Jingxin He |
| collection | DOAJ |
| description | Purpose. To investigate the longitudinal changes and associated factors of axial length (AL) in congenital ectopia lentis (CEL) patients. Methods. In this retrospective study, medical records of CEL patients were reviewed from January 2014 to December 2019 at the Zhongshan Ophthalmic (ZOC) in China. Patients were divided into the surgery group and the nonsurgery group. Data of refractive power, best-corrected visual acuity (BCVA), and intraocular pressure (IOP) as well as ocular biometrics including AL, corneal curvature, white-to-white (WTW), and central corneal thickness (CCT) were collected at baseline and each follow-up visit. Multiple linear regression was performed to assess the potential associated factors for axial length growth in congenital ectopia lentis patients. Results. Compared with the nonsurgery group, the change rate of AL among children aged 3 to 6 years old was slower in the surgery group (0.443 ± 0.340 mm/year vs. 0.278 ± 0.227 mm/year, P<0.05). However, no statistically significant difference for the change rate of AL was detected between the surgery group and the nonsurgery group (P>0.05) among patients aged 7 years or older. For the surgery group, the results of the linear regression model showed that a higher change rate of AL was associated with younger age (older age: β = −0.009, 95% CI: −0.014 to −0.003, and P=0.002) and worse baseline BCVA (logMAR) (β = 0.256, 95% CI: 0.072 to 0.439, and P=0.007). As for the nonsurgery group, younger baseline age (older age: β = −0.027, 95% CI: −0.048 to −0.007, and P=0.01) and longer baseline AL (β = 0.073, 95% CI: 0.023 to 0.122, and P=0.006) were associated with a higher change rate of AL. Conclusions. The AL change rate was clearly associated with age both in the surgery group and in the nonsurgery group. Intervention strategies such as surgery should be performed earlier for CEL that meets the surgical criteria. Worse baseline BCVA and longer baseline AL are associated factors that would affect the growth rate of AL in the surgery and nonsurgery group, respectively. |
| format | Article |
| id | doaj-art-74a763728658450e8aeeef6e4efd76a9 |
| institution | Kabale University |
| issn | 2090-0058 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-74a763728658450e8aeeef6e4efd76a92025-02-03T05:50:01ZengWileyJournal of Ophthalmology2090-00582022-01-01202210.1155/2022/4032283Longitudinal Changes of Axial Length and Associated Factors in Congenital Ectopia Lentis PatientsJingxin He0Zhangkai Lian1Qianzhong Cao2Zhenzhen Liu3Charlotte Aimee Young4Xinyu Zhang5Danying Zheng6Guangming Jin7State Key Laboratory of OphthalmologyState Key Laboratory of OphthalmologyState Key Laboratory of OphthalmologyState Key Laboratory of OphthalmologyDepartment of OphthalmologyState Key Laboratory of OphthalmologyState Key Laboratory of OphthalmologyState Key Laboratory of OphthalmologyPurpose. To investigate the longitudinal changes and associated factors of axial length (AL) in congenital ectopia lentis (CEL) patients. Methods. In this retrospective study, medical records of CEL patients were reviewed from January 2014 to December 2019 at the Zhongshan Ophthalmic (ZOC) in China. Patients were divided into the surgery group and the nonsurgery group. Data of refractive power, best-corrected visual acuity (BCVA), and intraocular pressure (IOP) as well as ocular biometrics including AL, corneal curvature, white-to-white (WTW), and central corneal thickness (CCT) were collected at baseline and each follow-up visit. Multiple linear regression was performed to assess the potential associated factors for axial length growth in congenital ectopia lentis patients. Results. Compared with the nonsurgery group, the change rate of AL among children aged 3 to 6 years old was slower in the surgery group (0.443 ± 0.340 mm/year vs. 0.278 ± 0.227 mm/year, P<0.05). However, no statistically significant difference for the change rate of AL was detected between the surgery group and the nonsurgery group (P>0.05) among patients aged 7 years or older. For the surgery group, the results of the linear regression model showed that a higher change rate of AL was associated with younger age (older age: β = −0.009, 95% CI: −0.014 to −0.003, and P=0.002) and worse baseline BCVA (logMAR) (β = 0.256, 95% CI: 0.072 to 0.439, and P=0.007). As for the nonsurgery group, younger baseline age (older age: β = −0.027, 95% CI: −0.048 to −0.007, and P=0.01) and longer baseline AL (β = 0.073, 95% CI: 0.023 to 0.122, and P=0.006) were associated with a higher change rate of AL. Conclusions. The AL change rate was clearly associated with age both in the surgery group and in the nonsurgery group. Intervention strategies such as surgery should be performed earlier for CEL that meets the surgical criteria. Worse baseline BCVA and longer baseline AL are associated factors that would affect the growth rate of AL in the surgery and nonsurgery group, respectively.http://dx.doi.org/10.1155/2022/4032283 |
| spellingShingle | Jingxin He Zhangkai Lian Qianzhong Cao Zhenzhen Liu Charlotte Aimee Young Xinyu Zhang Danying Zheng Guangming Jin Longitudinal Changes of Axial Length and Associated Factors in Congenital Ectopia Lentis Patients Journal of Ophthalmology |
| title | Longitudinal Changes of Axial Length and Associated Factors in Congenital Ectopia Lentis Patients |
| title_full | Longitudinal Changes of Axial Length and Associated Factors in Congenital Ectopia Lentis Patients |
| title_fullStr | Longitudinal Changes of Axial Length and Associated Factors in Congenital Ectopia Lentis Patients |
| title_full_unstemmed | Longitudinal Changes of Axial Length and Associated Factors in Congenital Ectopia Lentis Patients |
| title_short | Longitudinal Changes of Axial Length and Associated Factors in Congenital Ectopia Lentis Patients |
| title_sort | longitudinal changes of axial length and associated factors in congenital ectopia lentis patients |
| url | http://dx.doi.org/10.1155/2022/4032283 |
| work_keys_str_mv | AT jingxinhe longitudinalchangesofaxiallengthandassociatedfactorsincongenitalectopialentispatients AT zhangkailian longitudinalchangesofaxiallengthandassociatedfactorsincongenitalectopialentispatients AT qianzhongcao longitudinalchangesofaxiallengthandassociatedfactorsincongenitalectopialentispatients AT zhenzhenliu longitudinalchangesofaxiallengthandassociatedfactorsincongenitalectopialentispatients AT charlotteaimeeyoung longitudinalchangesofaxiallengthandassociatedfactorsincongenitalectopialentispatients AT xinyuzhang longitudinalchangesofaxiallengthandassociatedfactorsincongenitalectopialentispatients AT danyingzheng longitudinalchangesofaxiallengthandassociatedfactorsincongenitalectopialentispatients AT guangmingjin longitudinalchangesofaxiallengthandassociatedfactorsincongenitalectopialentispatients |