Fever
Measurement of body temperature remains one of the most common ways to assess health. An increase in temperature above what is considered to be a normal value is inevitably regarded as a sure sign of disease and referred to with one simple word: fever. In this review, we summarize how research on fe...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2010.50 |
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| _version_ | 1832567873466269696 |
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| author | Tamas Bartfai Bruno Conti |
| author_facet | Tamas Bartfai Bruno Conti |
| author_sort | Tamas Bartfai |
| collection | DOAJ |
| description | Measurement of body temperature remains one of the most common ways to assess health. An increase in temperature above what is considered to be a normal value is inevitably regarded as a sure sign of disease and referred to with one simple word: fever. In this review, we summarize how research on fever allowed the identification of the exogenous and endogenous molecules and pathways mediating the fever response. We also show how temperature elevation is common to different pathologies and how the molecular components of the fever-generation pathway represent drug targets for antipyretics, such as acetylsalicylic acid, the first “blockbuster drug”. We also show how fever research provided new insights into temperature and energy homeostasis, and into treatment of infection and inflammation. |
| format | Article |
| id | doaj-art-74935166a34f407ebc3dd0b8ea1ac08c |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-74935166a34f407ebc3dd0b8ea1ac08c2025-02-03T01:00:25ZengWileyThe Scientific World Journal1537-744X2010-01-011049050310.1100/tsw.2010.50FeverTamas Bartfai0Bruno Conti1Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA, USAMolecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA, USAMeasurement of body temperature remains one of the most common ways to assess health. An increase in temperature above what is considered to be a normal value is inevitably regarded as a sure sign of disease and referred to with one simple word: fever. In this review, we summarize how research on fever allowed the identification of the exogenous and endogenous molecules and pathways mediating the fever response. We also show how temperature elevation is common to different pathologies and how the molecular components of the fever-generation pathway represent drug targets for antipyretics, such as acetylsalicylic acid, the first “blockbuster drug”. We also show how fever research provided new insights into temperature and energy homeostasis, and into treatment of infection and inflammation.http://dx.doi.org/10.1100/tsw.2010.50 |
| spellingShingle | Tamas Bartfai Bruno Conti Fever The Scientific World Journal |
| title | Fever |
| title_full | Fever |
| title_fullStr | Fever |
| title_full_unstemmed | Fever |
| title_short | Fever |
| title_sort | fever |
| url | http://dx.doi.org/10.1100/tsw.2010.50 |
| work_keys_str_mv | AT tamasbartfai fever AT brunoconti fever |