Correlations between Traditional and Nontraditional Indicators of Adiposity, Inflammation, and Monocyte Subtypes in Patients with Stable Coronary Artery Disease
Background. Recruitment of monocytes and low-grade inflammation process are both involved in obesity and in atherosclerosis. Thus, the aim of this study was to evaluate the correlation among indicators of adiposity, monocyte subtypes, and inflammatory markers in patients with stable coronary artery...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2019/3139278 |
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| author | Silvia Bueno Garofallo Vera Lucia Portal Melissa Medeiros Markoski Lucinara Dadda Dias Alexandre Schaan de Quadrosa Aline Marcadenti |
| author_facet | Silvia Bueno Garofallo Vera Lucia Portal Melissa Medeiros Markoski Lucinara Dadda Dias Alexandre Schaan de Quadrosa Aline Marcadenti |
| author_sort | Silvia Bueno Garofallo |
| collection | DOAJ |
| description | Background. Recruitment of monocytes and low-grade inflammation process are both involved in obesity and in atherosclerosis. Thus, the aim of this study was to evaluate the correlation among indicators of adiposity, monocyte subtypes, and inflammatory markers in patients with stable coronary artery disease (CAD). Methods. This was a cross-sectional study including 97 patients with stable CAD aged >40 years. Traditional anthropometric indicators of adiposity (body mass index (BMI); waist, hip, and neck circumferences; and waist-hip ratio) and nontraditional anthropometric indicators of adiposity (lipid accumulation product index (LAP), visceral adiposity index (VAI), and deep-abdominal-adipose-tissue index (DAAT)) were determined. Immunoprecipitation, turbidimetry, coagulometric method, and CBA were used for the evaluation of inflammatory markers (hs-CRP, IL-2, IL-4, IL-6, IL-10, and INF-γ). Monocyte subtypes were identified by flow cytometry and defined as CD14++ CD16− (Mon1), CD14++ CD16+ (Mon2), and CD14+ CD16++ (Mon3). Pearson’s correlation coefficient and adjusted partial correlation were calculated. Results. Monocyte subtypes were correlated with inflammation regardless of nutritional status according to BMI. In overweight individuals, LAP was correlated with IL-4 and fibrinogen (P<0.01 and P<0.05, respectively) and VAI with IL-4 (P<0.05). In obese patients, the BMI, waist, neck, and hip circumferences, and DAAT were correlated with IL-6 (P<0.05), regardless of age and sex. The hip circumference was correlated positively with Mon1 (r = 0.40, P=0.007) and negatively with Mon3 (r = −0.35, P=0.02) in obese subjects. Conclusion. Monocyte subtypes are correlated with inflammation in patients with stable CAD independently of BMI, whereas traditional and nontraditional indicators of adiposity are correlated differently with inflammatory markers and monocytes, according to the nutritional status. |
| format | Article |
| id | doaj-art-748c539cde4b4809884ddbd6f9d8d6e5 |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-748c539cde4b4809884ddbd6f9d8d6e52025-02-03T01:28:40ZengWileyJournal of Obesity2090-07082090-07162019-01-01201910.1155/2019/31392783139278Correlations between Traditional and Nontraditional Indicators of Adiposity, Inflammation, and Monocyte Subtypes in Patients with Stable Coronary Artery DiseaseSilvia Bueno Garofallo0Vera Lucia Portal1Melissa Medeiros Markoski2Lucinara Dadda Dias3Alexandre Schaan de Quadrosa4Aline Marcadenti5Graduate Program in Health Sciences (Cardiology), Institute of Cardiology of Rio Grande do Sul/University Foundation of Cardiology (IC/FUC), Princesa Isabel Avenue, 395, Porto Alegre, Rio Grande do Sul 90040-371, BrazilGraduate Program in Health Sciences (Cardiology), Institute of Cardiology of Rio Grande do Sul/University Foundation of Cardiology (IC/FUC), Princesa Isabel Avenue, 395, Porto Alegre, Rio Grande do Sul 90040-371, BrazilGraduate Program in Nutrition Sciences, Federal University of Health Sciences of Porto Alegre (UFCSPA), Sarmento Leite Street, 245, Porto Alegre, Rio Grande do Sul 90050-170, BrazilGraduate Program in Health Sciences (Cardiology), Institute of Cardiology of Rio Grande do Sul/University Foundation of Cardiology (IC/FUC), Princesa Isabel Avenue, 395, Porto Alegre, Rio Grande do Sul 90040-371, BrazilGraduate Program in Health Sciences (Cardiology), Institute of Cardiology of Rio Grande do Sul/University Foundation of Cardiology (IC/FUC), Princesa Isabel Avenue, 395, Porto Alegre, Rio Grande do Sul 90040-371, BrazilGraduate Program in Health Sciences (Cardiology), Institute of Cardiology of Rio Grande do Sul/University Foundation of Cardiology (IC/FUC), Princesa Isabel Avenue, 395, Porto Alegre, Rio Grande do Sul 90040-371, BrazilBackground. Recruitment of monocytes and low-grade inflammation process are both involved in obesity and in atherosclerosis. Thus, the aim of this study was to evaluate the correlation among indicators of adiposity, monocyte subtypes, and inflammatory markers in patients with stable coronary artery disease (CAD). Methods. This was a cross-sectional study including 97 patients with stable CAD aged >40 years. Traditional anthropometric indicators of adiposity (body mass index (BMI); waist, hip, and neck circumferences; and waist-hip ratio) and nontraditional anthropometric indicators of adiposity (lipid accumulation product index (LAP), visceral adiposity index (VAI), and deep-abdominal-adipose-tissue index (DAAT)) were determined. Immunoprecipitation, turbidimetry, coagulometric method, and CBA were used for the evaluation of inflammatory markers (hs-CRP, IL-2, IL-4, IL-6, IL-10, and INF-γ). Monocyte subtypes were identified by flow cytometry and defined as CD14++ CD16− (Mon1), CD14++ CD16+ (Mon2), and CD14+ CD16++ (Mon3). Pearson’s correlation coefficient and adjusted partial correlation were calculated. Results. Monocyte subtypes were correlated with inflammation regardless of nutritional status according to BMI. In overweight individuals, LAP was correlated with IL-4 and fibrinogen (P<0.01 and P<0.05, respectively) and VAI with IL-4 (P<0.05). In obese patients, the BMI, waist, neck, and hip circumferences, and DAAT were correlated with IL-6 (P<0.05), regardless of age and sex. The hip circumference was correlated positively with Mon1 (r = 0.40, P=0.007) and negatively with Mon3 (r = −0.35, P=0.02) in obese subjects. Conclusion. Monocyte subtypes are correlated with inflammation in patients with stable CAD independently of BMI, whereas traditional and nontraditional indicators of adiposity are correlated differently with inflammatory markers and monocytes, according to the nutritional status.http://dx.doi.org/10.1155/2019/3139278 |
| spellingShingle | Silvia Bueno Garofallo Vera Lucia Portal Melissa Medeiros Markoski Lucinara Dadda Dias Alexandre Schaan de Quadrosa Aline Marcadenti Correlations between Traditional and Nontraditional Indicators of Adiposity, Inflammation, and Monocyte Subtypes in Patients with Stable Coronary Artery Disease Journal of Obesity |
| title | Correlations between Traditional and Nontraditional Indicators of Adiposity, Inflammation, and Monocyte Subtypes in Patients with Stable Coronary Artery Disease |
| title_full | Correlations between Traditional and Nontraditional Indicators of Adiposity, Inflammation, and Monocyte Subtypes in Patients with Stable Coronary Artery Disease |
| title_fullStr | Correlations between Traditional and Nontraditional Indicators of Adiposity, Inflammation, and Monocyte Subtypes in Patients with Stable Coronary Artery Disease |
| title_full_unstemmed | Correlations between Traditional and Nontraditional Indicators of Adiposity, Inflammation, and Monocyte Subtypes in Patients with Stable Coronary Artery Disease |
| title_short | Correlations between Traditional and Nontraditional Indicators of Adiposity, Inflammation, and Monocyte Subtypes in Patients with Stable Coronary Artery Disease |
| title_sort | correlations between traditional and nontraditional indicators of adiposity inflammation and monocyte subtypes in patients with stable coronary artery disease |
| url | http://dx.doi.org/10.1155/2019/3139278 |
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