Mushrooms, Microdosing, and Mental Illness: The Effect of Psilocybin on Neurotransmitters, Neuroinflammation, and Neuroplasticity
Daniel A Kinderlehrer Private Practice, Denver, CO, USACorrespondence: Daniel A Kinderlehrer, Email kinderlehrer@gmail.comAbstract: The incidence of mental health disorders is increasing worldwide. While there are multiple factors contributing to this problem, neuroinflammation underlies a significa...
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Dove Medical Press
2025-01-01
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| Series: | Neuropsychiatric Disease and Treatment |
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| Online Access: | https://www.dovepress.com/mushrooms-microdosing-and-mental-illness-the-effect-of-psilocybin-on-n-peer-reviewed-fulltext-article-NDT |
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| author | Kinderlehrer DA |
| author_facet | Kinderlehrer DA |
| author_sort | Kinderlehrer DA |
| collection | DOAJ |
| description | Daniel A Kinderlehrer Private Practice, Denver, CO, USACorrespondence: Daniel A Kinderlehrer, Email kinderlehrer@gmail.comAbstract: The incidence of mental health disorders is increasing worldwide. While there are multiple factors contributing to this problem, neuroinflammation underlies a significant subset of psychiatric conditions, particularly major depressive and anxiety disorders. Anti-inflammatory interventions have demonstrated benefit in these conditions. Psilocin, the active ingredient of mushrooms in the Psilocybe genus, is both a potent serotonin agonist and anti-inflammatory agent, increases neuroplasticity, and decreases overactivity in the default mode network. Studies using hallucinogenic doses of psilocin under the supervision of a therapist/guide have consistently demonstrated benefits to individuals with depression and end-of-life anxiety. Microdosing psilocybin in sub-hallucinogenic doses has also demonstrated benefit in mood disorders, and may offer a safe, less expensive, and more available alternative to full doses of psilocybin for mood disorders, as well as for other medical conditions in which inflammation is the principal pathophysiology.Keywords: Psilocybin, psilocin, microdose, depression, anxiety, neuroinflammation, anti-inflammatory |
| format | Article |
| id | doaj-art-7482638513b1430a9c7313bcf4324769 |
| institution | Kabale University |
| issn | 1178-2021 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Neuropsychiatric Disease and Treatment |
| spelling | doaj-art-7482638513b1430a9c7313bcf43247692025-01-30T18:07:17ZengDove Medical PressNeuropsychiatric Disease and Treatment1178-20212025-01-01Volume 2114115599706Mushrooms, Microdosing, and Mental Illness: The Effect of Psilocybin on Neurotransmitters, Neuroinflammation, and NeuroplasticityKinderlehrer DADaniel A Kinderlehrer Private Practice, Denver, CO, USACorrespondence: Daniel A Kinderlehrer, Email kinderlehrer@gmail.comAbstract: The incidence of mental health disorders is increasing worldwide. While there are multiple factors contributing to this problem, neuroinflammation underlies a significant subset of psychiatric conditions, particularly major depressive and anxiety disorders. Anti-inflammatory interventions have demonstrated benefit in these conditions. Psilocin, the active ingredient of mushrooms in the Psilocybe genus, is both a potent serotonin agonist and anti-inflammatory agent, increases neuroplasticity, and decreases overactivity in the default mode network. Studies using hallucinogenic doses of psilocin under the supervision of a therapist/guide have consistently demonstrated benefits to individuals with depression and end-of-life anxiety. Microdosing psilocybin in sub-hallucinogenic doses has also demonstrated benefit in mood disorders, and may offer a safe, less expensive, and more available alternative to full doses of psilocybin for mood disorders, as well as for other medical conditions in which inflammation is the principal pathophysiology.Keywords: Psilocybin, psilocin, microdose, depression, anxiety, neuroinflammation, anti-inflammatoryhttps://www.dovepress.com/mushrooms-microdosing-and-mental-illness-the-effect-of-psilocybin-on-n-peer-reviewed-fulltext-article-NDTpsilocybinpsilocinmicrodosedepressionanxietyneuroinflammationanti-inflammatory |
| spellingShingle | Kinderlehrer DA Mushrooms, Microdosing, and Mental Illness: The Effect of Psilocybin on Neurotransmitters, Neuroinflammation, and Neuroplasticity Neuropsychiatric Disease and Treatment psilocybin psilocin microdose depression anxiety neuroinflammation anti-inflammatory |
| title | Mushrooms, Microdosing, and Mental Illness: The Effect of Psilocybin on Neurotransmitters, Neuroinflammation, and Neuroplasticity |
| title_full | Mushrooms, Microdosing, and Mental Illness: The Effect of Psilocybin on Neurotransmitters, Neuroinflammation, and Neuroplasticity |
| title_fullStr | Mushrooms, Microdosing, and Mental Illness: The Effect of Psilocybin on Neurotransmitters, Neuroinflammation, and Neuroplasticity |
| title_full_unstemmed | Mushrooms, Microdosing, and Mental Illness: The Effect of Psilocybin on Neurotransmitters, Neuroinflammation, and Neuroplasticity |
| title_short | Mushrooms, Microdosing, and Mental Illness: The Effect of Psilocybin on Neurotransmitters, Neuroinflammation, and Neuroplasticity |
| title_sort | mushrooms microdosing and mental illness the effect of psilocybin on neurotransmitters neuroinflammation and neuroplasticity |
| topic | psilocybin psilocin microdose depression anxiety neuroinflammation anti-inflammatory |
| url | https://www.dovepress.com/mushrooms-microdosing-and-mental-illness-the-effect-of-psilocybin-on-n-peer-reviewed-fulltext-article-NDT |
| work_keys_str_mv | AT kinderlehrerda mushroomsmicrodosingandmentalillnesstheeffectofpsilocybinonneurotransmittersneuroinflammationandneuroplasticity |