A Comprehensive Review of Ethnomedicinal Uses, Phytochemistry, Pharmacology, and Toxicity of Prunus africana (Hook. F.) Kalkman from Africa
Prunus africana, a widely utilized medicinal plant in various African ethnic communities, continues to hold significant importance in traditional healing practices. Research has identified phytochemical compounds in this plant, exhibiting diverse pharmacological activities that offer potential for p...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-01-01
|
| Series: | Scientifica |
| Online Access: | http://dx.doi.org/10.1155/2024/8862996 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832559287093690368 |
|---|---|
| author | James K. Ndung’u Joseph M. Nguta Isaac M. Mapenay Gervason A. Moriasi |
| author_facet | James K. Ndung’u Joseph M. Nguta Isaac M. Mapenay Gervason A. Moriasi |
| author_sort | James K. Ndung’u |
| collection | DOAJ |
| description | Prunus africana, a widely utilized medicinal plant in various African ethnic communities, continues to hold significant importance in traditional healing practices. Research has identified phytochemical compounds in this plant, exhibiting diverse pharmacological activities that offer potential for pharmaceutical development. Notably, P. africana is employed in treating various ailments such as wounds, diabetes mellitus, malaria, benign prostatic hyperplasia, chest pain, and prostate cancer. Its pharmacological properties are attributed to a spectrum of bioactive compounds, including tannins, saponins, alkaloids, flavonoids, terpenoids, phytosterols, and fatty acids. Multiple studies have documented the anti-inflammatory, antimicrobial, antiandrogenic, antiangiogenic, antioxidant, antidipeptidyl peptidase-4 activity, analgesic, and astringent properties of P. africana extracts. This review offers a comprehensive compilation of ethnomedicinal applications, phytochemical composition, pharmacological effects, and toxicity assessments of P. africana, serving as a foundation for future preclinical and clinical investigations. By understanding its traditional uses and chemical constituents, researchers can target specific medical conditions with greater precision, potentially expediting the development of safe and effective pharmaceuticals. Moreover, toxicity assessments provide crucial insights into the safety profile of P. africana extracts, ensuring the development of safe pharmaceuticals to treat various diseases. |
| format | Article |
| id | doaj-art-7480834bebf54ed0aacd15ede58f5025 |
| institution | Kabale University |
| issn | 2090-908X |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Scientifica |
| spelling | doaj-art-7480834bebf54ed0aacd15ede58f50252025-02-03T01:30:22ZengWileyScientifica2090-908X2024-01-01202410.1155/2024/8862996A Comprehensive Review of Ethnomedicinal Uses, Phytochemistry, Pharmacology, and Toxicity of Prunus africana (Hook. F.) Kalkman from AfricaJames K. Ndung’u0Joseph M. Nguta1Isaac M. Mapenay2Gervason A. Moriasi3Department of Public Health, Pharmacology, and ToxicologyDepartment of Public Health, Pharmacology, and ToxicologyDepartment of Public Health, Pharmacology, and ToxicologyDepartment of BiochemistryPrunus africana, a widely utilized medicinal plant in various African ethnic communities, continues to hold significant importance in traditional healing practices. Research has identified phytochemical compounds in this plant, exhibiting diverse pharmacological activities that offer potential for pharmaceutical development. Notably, P. africana is employed in treating various ailments such as wounds, diabetes mellitus, malaria, benign prostatic hyperplasia, chest pain, and prostate cancer. Its pharmacological properties are attributed to a spectrum of bioactive compounds, including tannins, saponins, alkaloids, flavonoids, terpenoids, phytosterols, and fatty acids. Multiple studies have documented the anti-inflammatory, antimicrobial, antiandrogenic, antiangiogenic, antioxidant, antidipeptidyl peptidase-4 activity, analgesic, and astringent properties of P. africana extracts. This review offers a comprehensive compilation of ethnomedicinal applications, phytochemical composition, pharmacological effects, and toxicity assessments of P. africana, serving as a foundation for future preclinical and clinical investigations. By understanding its traditional uses and chemical constituents, researchers can target specific medical conditions with greater precision, potentially expediting the development of safe and effective pharmaceuticals. Moreover, toxicity assessments provide crucial insights into the safety profile of P. africana extracts, ensuring the development of safe pharmaceuticals to treat various diseases.http://dx.doi.org/10.1155/2024/8862996 |
| spellingShingle | James K. Ndung’u Joseph M. Nguta Isaac M. Mapenay Gervason A. Moriasi A Comprehensive Review of Ethnomedicinal Uses, Phytochemistry, Pharmacology, and Toxicity of Prunus africana (Hook. F.) Kalkman from Africa Scientifica |
| title | A Comprehensive Review of Ethnomedicinal Uses, Phytochemistry, Pharmacology, and Toxicity of Prunus africana (Hook. F.) Kalkman from Africa |
| title_full | A Comprehensive Review of Ethnomedicinal Uses, Phytochemistry, Pharmacology, and Toxicity of Prunus africana (Hook. F.) Kalkman from Africa |
| title_fullStr | A Comprehensive Review of Ethnomedicinal Uses, Phytochemistry, Pharmacology, and Toxicity of Prunus africana (Hook. F.) Kalkman from Africa |
| title_full_unstemmed | A Comprehensive Review of Ethnomedicinal Uses, Phytochemistry, Pharmacology, and Toxicity of Prunus africana (Hook. F.) Kalkman from Africa |
| title_short | A Comprehensive Review of Ethnomedicinal Uses, Phytochemistry, Pharmacology, and Toxicity of Prunus africana (Hook. F.) Kalkman from Africa |
| title_sort | comprehensive review of ethnomedicinal uses phytochemistry pharmacology and toxicity of prunus africana hook f kalkman from africa |
| url | http://dx.doi.org/10.1155/2024/8862996 |
| work_keys_str_mv | AT jameskndungu acomprehensivereviewofethnomedicinalusesphytochemistrypharmacologyandtoxicityofprunusafricanahookfkalkmanfromafrica AT josephmnguta acomprehensivereviewofethnomedicinalusesphytochemistrypharmacologyandtoxicityofprunusafricanahookfkalkmanfromafrica AT isaacmmapenay acomprehensivereviewofethnomedicinalusesphytochemistrypharmacologyandtoxicityofprunusafricanahookfkalkmanfromafrica AT gervasonamoriasi acomprehensivereviewofethnomedicinalusesphytochemistrypharmacologyandtoxicityofprunusafricanahookfkalkmanfromafrica AT jameskndungu comprehensivereviewofethnomedicinalusesphytochemistrypharmacologyandtoxicityofprunusafricanahookfkalkmanfromafrica AT josephmnguta comprehensivereviewofethnomedicinalusesphytochemistrypharmacologyandtoxicityofprunusafricanahookfkalkmanfromafrica AT isaacmmapenay comprehensivereviewofethnomedicinalusesphytochemistrypharmacologyandtoxicityofprunusafricanahookfkalkmanfromafrica AT gervasonamoriasi comprehensivereviewofethnomedicinalusesphytochemistrypharmacologyandtoxicityofprunusafricanahookfkalkmanfromafrica |