Serum Bile Acid Profiles in Latent Autoimmune Diabetes in Adults and Type 2 Diabetes Patients
Background. Impaired bile acid (BA) metabolism has been associated with the progression of type 2 diabetes (T2D). However, the contribution of BAs to the pathogenesis of latent autoimmune diabetes in adults (LADA) remains unclear. This study was aimed at investigating the association of serum BAs wi...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2022/2391188 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832567039010537472 |
|---|---|
| author | Yu Zhou Deli Ye Xiaofen Yuan Yonglie Zhou Jun Xia |
| author_facet | Yu Zhou Deli Ye Xiaofen Yuan Yonglie Zhou Jun Xia |
| author_sort | Yu Zhou |
| collection | DOAJ |
| description | Background. Impaired bile acid (BA) metabolism has been associated with the progression of type 2 diabetes (T2D). However, the contribution of BAs to the pathogenesis of latent autoimmune diabetes in adults (LADA) remains unclear. This study was aimed at investigating the association of serum BAs with different diabetes types and analyzing its correlation with main clinical and laboratory parameters. Methods. Patients with LADA, patients with T2D, and healthy controls (HCs) were enrolled. Serum BA profiles and inflammatory cytokines were measured. The correlation of BA species with different indicators was assessed by Spearman’s correlation method. Results. Patients with diabetes (LADA and T2D) had significantly higher serum BAs, especially conjugated BAs, compared with those in HCs. Nevertheless, serum BA profiles had no special role in the progression of LADA, because no significant differences in BAs were observed between LADA and T2D patients. Interestingly, HbA1c levels and HOMA-β were found to be correlated with a series of BA species. Proinflammatory cytokines (IL-1β, IL-6, and TNF-α) and anti-inflammatory cytokine (IL-10) were all positively associated with several BA species, especially the conjugated secondary BAs. Conclusion. Serum BAs regulate glucose homeostasis, but have no special value in the pathogenesis of LADA patients. Our study adds further information about the potential value of serum BAs in different types of diabetes. |
| format | Article |
| id | doaj-art-746cc104fdaa4ced893b78c45977b35a |
| institution | Kabale University |
| issn | 2314-6753 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-746cc104fdaa4ced893b78c45977b35a2025-02-03T01:02:29ZengWileyJournal of Diabetes Research2314-67532022-01-01202210.1155/2022/2391188Serum Bile Acid Profiles in Latent Autoimmune Diabetes in Adults and Type 2 Diabetes PatientsYu Zhou0Deli Ye1Xiaofen Yuan2Yonglie Zhou3Jun Xia4Department of Clinical LaboratoryDepartment of Clinical LaboratoryHangzhou Calibra Diagnostics Co.Department of Clinical LaboratoryDepartment of Clinical LaboratoryBackground. Impaired bile acid (BA) metabolism has been associated with the progression of type 2 diabetes (T2D). However, the contribution of BAs to the pathogenesis of latent autoimmune diabetes in adults (LADA) remains unclear. This study was aimed at investigating the association of serum BAs with different diabetes types and analyzing its correlation with main clinical and laboratory parameters. Methods. Patients with LADA, patients with T2D, and healthy controls (HCs) were enrolled. Serum BA profiles and inflammatory cytokines were measured. The correlation of BA species with different indicators was assessed by Spearman’s correlation method. Results. Patients with diabetes (LADA and T2D) had significantly higher serum BAs, especially conjugated BAs, compared with those in HCs. Nevertheless, serum BA profiles had no special role in the progression of LADA, because no significant differences in BAs were observed between LADA and T2D patients. Interestingly, HbA1c levels and HOMA-β were found to be correlated with a series of BA species. Proinflammatory cytokines (IL-1β, IL-6, and TNF-α) and anti-inflammatory cytokine (IL-10) were all positively associated with several BA species, especially the conjugated secondary BAs. Conclusion. Serum BAs regulate glucose homeostasis, but have no special value in the pathogenesis of LADA patients. Our study adds further information about the potential value of serum BAs in different types of diabetes.http://dx.doi.org/10.1155/2022/2391188 |
| spellingShingle | Yu Zhou Deli Ye Xiaofen Yuan Yonglie Zhou Jun Xia Serum Bile Acid Profiles in Latent Autoimmune Diabetes in Adults and Type 2 Diabetes Patients Journal of Diabetes Research |
| title | Serum Bile Acid Profiles in Latent Autoimmune Diabetes in Adults and Type 2 Diabetes Patients |
| title_full | Serum Bile Acid Profiles in Latent Autoimmune Diabetes in Adults and Type 2 Diabetes Patients |
| title_fullStr | Serum Bile Acid Profiles in Latent Autoimmune Diabetes in Adults and Type 2 Diabetes Patients |
| title_full_unstemmed | Serum Bile Acid Profiles in Latent Autoimmune Diabetes in Adults and Type 2 Diabetes Patients |
| title_short | Serum Bile Acid Profiles in Latent Autoimmune Diabetes in Adults and Type 2 Diabetes Patients |
| title_sort | serum bile acid profiles in latent autoimmune diabetes in adults and type 2 diabetes patients |
| url | http://dx.doi.org/10.1155/2022/2391188 |
| work_keys_str_mv | AT yuzhou serumbileacidprofilesinlatentautoimmunediabetesinadultsandtype2diabetespatients AT deliye serumbileacidprofilesinlatentautoimmunediabetesinadultsandtype2diabetespatients AT xiaofenyuan serumbileacidprofilesinlatentautoimmunediabetesinadultsandtype2diabetespatients AT yongliezhou serumbileacidprofilesinlatentautoimmunediabetesinadultsandtype2diabetespatients AT junxia serumbileacidprofilesinlatentautoimmunediabetesinadultsandtype2diabetespatients |