Age-Related Reduced Somatosensory Gating Is Associated with Altered Alpha Frequency Desynchronization
Sensory gating (SG), referring to an attenuated neural response to the second identical stimulus, is considered as preattentive processing in the central nervous system to filter redundant sensory inputs. Insufficient somatosensory SG has been found in the aged adults, particularly in the secondary...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2015/302878 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832566764389531648 |
|---|---|
| author | Chia-Hsiung Cheng Pei-Ying S. Chan Sylvain Baillet Yung-Yang Lin |
| author_facet | Chia-Hsiung Cheng Pei-Ying S. Chan Sylvain Baillet Yung-Yang Lin |
| author_sort | Chia-Hsiung Cheng |
| collection | DOAJ |
| description | Sensory gating (SG), referring to an attenuated neural response to the second identical stimulus, is considered as preattentive processing in the central nervous system to filter redundant sensory inputs. Insufficient somatosensory SG has been found in the aged adults, particularly in the secondary somatosensory cortex (SII). However, it remains unclear which variables leading to the age-related somatosensory SG decline. There has been evidence showing a relationship between brain oscillations and cortical evoked excitability. Thus, this study used whole-head magnetoencephalography to record responses to paired-pulse electrical stimulation to the left median nerve in healthy young and elderly participants to test whether insufficient stimulus 1- (S1-) induced event-related desynchronization (ERD) contributes to a less-suppressed stimulus 2- (S2-) evoked response. Our analysis revealed that the minimum norm estimates showed age-related reduction of SG in the bilateral SII regions. Spectral power analysis showed that the elderly demonstrated significantly reduced alpha ERD in the contralateral SII (SIIc). Moreover, it was striking to note that lower S1-induced alpha ERD was associated with higher S2-evoked amplitudes in the SIIc among the aged adults. Conclusively, our findings suggest that age-related decline of somatosensory SG is partially attributed to the altered S1-induced oscillatory activity. |
| format | Article |
| id | doaj-art-746a884ce90a4b2a87b5ccfcc8109484 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-746a884ce90a4b2a87b5ccfcc81094842025-02-03T01:03:17ZengWileyNeural Plasticity2090-59041687-54432015-01-01201510.1155/2015/302878302878Age-Related Reduced Somatosensory Gating Is Associated with Altered Alpha Frequency DesynchronizationChia-Hsiung Cheng0Pei-Ying S. Chan1Sylvain Baillet2Yung-Yang Lin3Department of Occupational Therapy and Graduate Institute of Behavioral Sciences, Chang Gung University, Taoyuan, TaiwanDepartment of Occupational Therapy and Graduate Institute of Behavioral Sciences, Chang Gung University, Taoyuan, TaiwanMcConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, No. 3801, University Street, Montreal, QC, H3A 2B4, CanadaInstitute of Brain Science, National Yang-Ming University, Taipei, TaiwanSensory gating (SG), referring to an attenuated neural response to the second identical stimulus, is considered as preattentive processing in the central nervous system to filter redundant sensory inputs. Insufficient somatosensory SG has been found in the aged adults, particularly in the secondary somatosensory cortex (SII). However, it remains unclear which variables leading to the age-related somatosensory SG decline. There has been evidence showing a relationship between brain oscillations and cortical evoked excitability. Thus, this study used whole-head magnetoencephalography to record responses to paired-pulse electrical stimulation to the left median nerve in healthy young and elderly participants to test whether insufficient stimulus 1- (S1-) induced event-related desynchronization (ERD) contributes to a less-suppressed stimulus 2- (S2-) evoked response. Our analysis revealed that the minimum norm estimates showed age-related reduction of SG in the bilateral SII regions. Spectral power analysis showed that the elderly demonstrated significantly reduced alpha ERD in the contralateral SII (SIIc). Moreover, it was striking to note that lower S1-induced alpha ERD was associated with higher S2-evoked amplitudes in the SIIc among the aged adults. Conclusively, our findings suggest that age-related decline of somatosensory SG is partially attributed to the altered S1-induced oscillatory activity.http://dx.doi.org/10.1155/2015/302878 |
| spellingShingle | Chia-Hsiung Cheng Pei-Ying S. Chan Sylvain Baillet Yung-Yang Lin Age-Related Reduced Somatosensory Gating Is Associated with Altered Alpha Frequency Desynchronization Neural Plasticity |
| title | Age-Related Reduced Somatosensory Gating Is Associated with Altered Alpha Frequency Desynchronization |
| title_full | Age-Related Reduced Somatosensory Gating Is Associated with Altered Alpha Frequency Desynchronization |
| title_fullStr | Age-Related Reduced Somatosensory Gating Is Associated with Altered Alpha Frequency Desynchronization |
| title_full_unstemmed | Age-Related Reduced Somatosensory Gating Is Associated with Altered Alpha Frequency Desynchronization |
| title_short | Age-Related Reduced Somatosensory Gating Is Associated with Altered Alpha Frequency Desynchronization |
| title_sort | age related reduced somatosensory gating is associated with altered alpha frequency desynchronization |
| url | http://dx.doi.org/10.1155/2015/302878 |
| work_keys_str_mv | AT chiahsiungcheng agerelatedreducedsomatosensorygatingisassociatedwithalteredalphafrequencydesynchronization AT peiyingschan agerelatedreducedsomatosensorygatingisassociatedwithalteredalphafrequencydesynchronization AT sylvainbaillet agerelatedreducedsomatosensorygatingisassociatedwithalteredalphafrequencydesynchronization AT yungyanglin agerelatedreducedsomatosensorygatingisassociatedwithalteredalphafrequencydesynchronization |