Analysis of Foveal and Parafoveal Microvascular Density and Retinal Vessel Caliber Alteration in Inactive Graves’ Ophthalmopathy
Purpose. We aimed to evaluate foveal and parafoveal density using optical coherence tomography angiography and the alteration on the retinal vessel diameter in patients with inactive Graves’ ophthalmopathy compared to age-matched normal population. Materials and Methods. Patients with inactive Grave...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2020/7643737 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832566074539769856 |
|---|---|
| author | Cetin Akpolat Muhammed M. Kurt Merve Yılmaz Fikriye Ordulu Ferhat Evliyaoglu |
| author_facet | Cetin Akpolat Muhammed M. Kurt Merve Yılmaz Fikriye Ordulu Ferhat Evliyaoglu |
| author_sort | Cetin Akpolat |
| collection | DOAJ |
| description | Purpose. We aimed to evaluate foveal and parafoveal density using optical coherence tomography angiography and the alteration on the retinal vessel diameter in patients with inactive Graves’ ophthalmopathy compared to age-matched normal population. Materials and Methods. Patients with inactive Graves’ ophthalmopathy (study group) and healthy individuals (control group) were enrolled in the cross sectionally designed study. The optical coherence tomography angiography parameters and retinal vessel diameter measurements were assessed between the study and control groups. Foveal and parafoveal microvascular density in the retina was measured using optical coherence tomography angiography. Retinal artery and vein diameter and artery/vein ratio were assessed for retinal vessel caliber changes. Results. Patients with inactive Graves’ ophthalmopathy had higher values of intraocular pressure, proptosis, and axial length (P=0.001, P=0.002, and P=0.008, respectively). Temporal parafoveal vessel density was 48.93 ± 3.21 and 47.62 ± 2.59 in the study and control groups, respectively (P=0.017). Nasal parafoveal vessel density was 47.55 ± 3.01 and 46.46 ± 2.57 in the study and control groups, respectively (P=0.035). Foveal, superior, and inferior parafoveal vessel density values were similar in the study and control groups (P=0.268, P=0.107, and P=0.055, respectively). Patients in the study group had narrower retinal artery and vein diameters (P≤0.001 and P=0.033). Artery/vein ratio was significantly higher in the control group (P≤0.001). Conclusion. Optical coherence tomography angiography could be a novel and promising noninvasive diagnostic technique in patients with inactive Graves’ ophthalmopathy to detect foveal and parafoveal vessel density changes compared to healthy subjects. The decrease of retinal vessel diameter might be observed in patients with inactive graves ophthalmopathy. |
| format | Article |
| id | doaj-art-745078cdf8b14689a32b498a4f99eb29 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-745078cdf8b14689a32b498a4f99eb292025-02-03T01:05:06ZengWileyJournal of Ophthalmology2090-004X2090-00582020-01-01202010.1155/2020/76437377643737Analysis of Foveal and Parafoveal Microvascular Density and Retinal Vessel Caliber Alteration in Inactive Graves’ OphthalmopathyCetin Akpolat0Muhammed M. Kurt1Merve Yılmaz2Fikriye Ordulu3Ferhat Evliyaoglu4Department of Ophthalmology, Sisli Hamidiye Etfal Training and Research Hospital, İstanbul, TurkeyDepartment of Ophthalmology, Samsun Gazi Community Hospital, Samsun, TurkeyDepartment of Endocrinology, Samsun Gazi Community Hospital, Samsun, TurkeyDepartment of Ophthalmology, Samsun Gazi Community Hospital, Samsun, TurkeyDepartment of Ophthalmology, Umraniye Training and Research Hospital, İstanbul, TurkeyPurpose. We aimed to evaluate foveal and parafoveal density using optical coherence tomography angiography and the alteration on the retinal vessel diameter in patients with inactive Graves’ ophthalmopathy compared to age-matched normal population. Materials and Methods. Patients with inactive Graves’ ophthalmopathy (study group) and healthy individuals (control group) were enrolled in the cross sectionally designed study. The optical coherence tomography angiography parameters and retinal vessel diameter measurements were assessed between the study and control groups. Foveal and parafoveal microvascular density in the retina was measured using optical coherence tomography angiography. Retinal artery and vein diameter and artery/vein ratio were assessed for retinal vessel caliber changes. Results. Patients with inactive Graves’ ophthalmopathy had higher values of intraocular pressure, proptosis, and axial length (P=0.001, P=0.002, and P=0.008, respectively). Temporal parafoveal vessel density was 48.93 ± 3.21 and 47.62 ± 2.59 in the study and control groups, respectively (P=0.017). Nasal parafoveal vessel density was 47.55 ± 3.01 and 46.46 ± 2.57 in the study and control groups, respectively (P=0.035). Foveal, superior, and inferior parafoveal vessel density values were similar in the study and control groups (P=0.268, P=0.107, and P=0.055, respectively). Patients in the study group had narrower retinal artery and vein diameters (P≤0.001 and P=0.033). Artery/vein ratio was significantly higher in the control group (P≤0.001). Conclusion. Optical coherence tomography angiography could be a novel and promising noninvasive diagnostic technique in patients with inactive Graves’ ophthalmopathy to detect foveal and parafoveal vessel density changes compared to healthy subjects. The decrease of retinal vessel diameter might be observed in patients with inactive graves ophthalmopathy.http://dx.doi.org/10.1155/2020/7643737 |
| spellingShingle | Cetin Akpolat Muhammed M. Kurt Merve Yılmaz Fikriye Ordulu Ferhat Evliyaoglu Analysis of Foveal and Parafoveal Microvascular Density and Retinal Vessel Caliber Alteration in Inactive Graves’ Ophthalmopathy Journal of Ophthalmology |
| title | Analysis of Foveal and Parafoveal Microvascular Density and Retinal Vessel Caliber Alteration in Inactive Graves’ Ophthalmopathy |
| title_full | Analysis of Foveal and Parafoveal Microvascular Density and Retinal Vessel Caliber Alteration in Inactive Graves’ Ophthalmopathy |
| title_fullStr | Analysis of Foveal and Parafoveal Microvascular Density and Retinal Vessel Caliber Alteration in Inactive Graves’ Ophthalmopathy |
| title_full_unstemmed | Analysis of Foveal and Parafoveal Microvascular Density and Retinal Vessel Caliber Alteration in Inactive Graves’ Ophthalmopathy |
| title_short | Analysis of Foveal and Parafoveal Microvascular Density and Retinal Vessel Caliber Alteration in Inactive Graves’ Ophthalmopathy |
| title_sort | analysis of foveal and parafoveal microvascular density and retinal vessel caliber alteration in inactive graves ophthalmopathy |
| url | http://dx.doi.org/10.1155/2020/7643737 |
| work_keys_str_mv | AT cetinakpolat analysisoffovealandparafovealmicrovasculardensityandretinalvesselcaliberalterationininactivegravesophthalmopathy AT muhammedmkurt analysisoffovealandparafovealmicrovasculardensityandretinalvesselcaliberalterationininactivegravesophthalmopathy AT merveyılmaz analysisoffovealandparafovealmicrovasculardensityandretinalvesselcaliberalterationininactivegravesophthalmopathy AT fikriyeordulu analysisoffovealandparafovealmicrovasculardensityandretinalvesselcaliberalterationininactivegravesophthalmopathy AT ferhatevliyaoglu analysisoffovealandparafovealmicrovasculardensityandretinalvesselcaliberalterationininactivegravesophthalmopathy |