Drug-Induced Liver Injury Associated with the Use of Everolimus in a Liver Transplant Patient
Drug-induced liver injury (DILI) has not been previously reported as a complication of treatment with everolimus. A 56-year-old Caucasian male liver transplant recipient developed DILI after receiving everolimus. Elevations in transaminase levels occurred within a week of starting everolimus and an...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2018/7410508 |
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| _version_ | 1832548611486908416 |
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| author | Serena Patel Michel H. Mendler Mark A. Valasek Shirley M. Tsunoda |
| author_facet | Serena Patel Michel H. Mendler Mark A. Valasek Shirley M. Tsunoda |
| author_sort | Serena Patel |
| collection | DOAJ |
| description | Drug-induced liver injury (DILI) has not been previously reported as a complication of treatment with everolimus. A 56-year-old Caucasian male liver transplant recipient developed DILI after receiving everolimus. Elevations in transaminase levels occurred within a week of starting everolimus and an upward trend in the transaminase levels continued with supporting histopathologic changes confirmed by liver biopsy. Within one week of drug discontinuation, his liver enzymes normalized to baseline. This report includes a brief review of the pharmacokinetic properties of everolimus, a review of the relevant literature, and an analysis using the RUCAM and Naranjo algorithms. |
| format | Article |
| id | doaj-art-744fd1535193465bb1c584bf0671c5fa |
| institution | Kabale University |
| issn | 2090-6943 2090-6951 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Transplantation |
| spelling | doaj-art-744fd1535193465bb1c584bf0671c5fa2025-02-03T06:13:29ZengWileyCase Reports in Transplantation2090-69432090-69512018-01-01201810.1155/2018/74105087410508Drug-Induced Liver Injury Associated with the Use of Everolimus in a Liver Transplant PatientSerena Patel0Michel H. Mendler1Mark A. Valasek2Shirley M. Tsunoda3University of California (UC) San Diego, Skaggs School of Pharmacy and Pharmaceutical Sciences, USAUC San Diego, Department of Medicine, Division of Hepatology, USAUC San Diego, Department of Pathology, USAUniversity of California (UC) San Diego, Skaggs School of Pharmacy and Pharmaceutical Sciences, USADrug-induced liver injury (DILI) has not been previously reported as a complication of treatment with everolimus. A 56-year-old Caucasian male liver transplant recipient developed DILI after receiving everolimus. Elevations in transaminase levels occurred within a week of starting everolimus and an upward trend in the transaminase levels continued with supporting histopathologic changes confirmed by liver biopsy. Within one week of drug discontinuation, his liver enzymes normalized to baseline. This report includes a brief review of the pharmacokinetic properties of everolimus, a review of the relevant literature, and an analysis using the RUCAM and Naranjo algorithms.http://dx.doi.org/10.1155/2018/7410508 |
| spellingShingle | Serena Patel Michel H. Mendler Mark A. Valasek Shirley M. Tsunoda Drug-Induced Liver Injury Associated with the Use of Everolimus in a Liver Transplant Patient Case Reports in Transplantation |
| title | Drug-Induced Liver Injury Associated with the Use of Everolimus in a Liver Transplant Patient |
| title_full | Drug-Induced Liver Injury Associated with the Use of Everolimus in a Liver Transplant Patient |
| title_fullStr | Drug-Induced Liver Injury Associated with the Use of Everolimus in a Liver Transplant Patient |
| title_full_unstemmed | Drug-Induced Liver Injury Associated with the Use of Everolimus in a Liver Transplant Patient |
| title_short | Drug-Induced Liver Injury Associated with the Use of Everolimus in a Liver Transplant Patient |
| title_sort | drug induced liver injury associated with the use of everolimus in a liver transplant patient |
| url | http://dx.doi.org/10.1155/2018/7410508 |
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