Valosin-containing protein (VCP), a component of tumor-derived extracellular vesicles, impairs the barrier integrity of brain microvascular endothelial cells

Valosin-containing protein (VCP), a component of tumor-derived extracellular vesicles, impairs the barrier integrity of brain microvascular endothelial cells

Metastases are the leading cause of cancer-related deaths, and their origin is not fully elucidated. Recently, studies have shown that extracellular vesicles (EVs), particularly small extracellular vesicles (sEV), can disrupt the homeostasis of organs, promoting the development of a secondary tumor....

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Bibliographic Details
Main Authors: Ramon Handerson Gomes Teles, Nicolas Jones Villarinho, Ana Sayuri Yamagata, Camila Tamy Hiroki, Murilo Camargo de Oliveira, Gisela Ramos Terçarioli, Ruy Gastaldoni Jaeger, Patrick Meybohm, Malgorzata Burek, Vanessa Morais Freitas
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:BBA Advances
Subjects:
Extracellular vesicles
Exosomes
Microvesicles
Breast cancer
Metastasis
hCMEC/D3
Online Access:http://www.sciencedirect.com/science/article/pii/S2667160324000188
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