Interaction Effects of Lipoprotein Lipase Polymorphisms with Lifestyle on Lipid Levels in a Korean Population: A Cross-sectional Study
Lipoprotein lipase (LPL) plays an essential role in the regulation of high-density lipoprotein cholesterol (HDLC) and triglyceride levels, which have been closely associated with cardiovascular diseases. Genetic studies in European have shown that LPL single-nucleotide polymorphisms (SNPs) are stron...
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BioMed Central
2012-06-01
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| Series: | Genomics & Informatics |
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| Online Access: | http://genominfo.org/upload/pdf/gni-10-88.pdf |
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| author | Jung-A Pyun Sunshin Kim KyungChae Park Inkyung Baik Nam H Cho InSong Koh Jong-Young Lee Yoon Shin Cho Young Jin Kim Min Jin Go Eugene Shim KyuBum Kwack Chol Shin |
| author_facet | Jung-A Pyun Sunshin Kim KyungChae Park Inkyung Baik Nam H Cho InSong Koh Jong-Young Lee Yoon Shin Cho Young Jin Kim Min Jin Go Eugene Shim KyuBum Kwack Chol Shin |
| author_sort | Jung-A Pyun |
| collection | DOAJ |
| description | Lipoprotein lipase (LPL) plays an essential role in the regulation of high-density lipoprotein cholesterol (HDLC) and triglyceride levels, which have been closely associated with cardiovascular diseases. Genetic studies in European have shown that LPL single-nucleotide polymorphisms (SNPs) are strongly associated with lipid levels. However, studies about the influence of interactions between LPL SNPs and lifestyle factors have not been sufficiently performed. Here, we examine if LPL polymorphisms, as well as their interaction with lifestyle factors, influence lipid concentrations in a Korean population. A two-stage association study was performed using genotype data for SNPs on the LPL gene, including the 3' flanking region from 7,536 (stage 1) and 3,703 (stage 2) individuals. The association study showed that 15 SNPs and 4 haplotypes were strongly associated with HDLC (lowest p = 2.86 × 10-22) and triglyceride levels (lowest p = 3.0 × 10-15). Interactions between LPL polymorphisms and lifestyle factors (lowest p = 9.6 × 10-4) were also observed on lipid concentrations. These findings suggest that there are interaction effects of LPL polymorphisms with lifestyle variables, including energy intake, fat intake, smoking, and alcohol consumption, as well as effects of LPL polymorphisms themselves, on lipid concentrations in a Korean population. |
| format | Article |
| id | doaj-art-743eebf79a8a423baa193d7525dff1dd |
| institution | Kabale University |
| issn | 1598-866X 2234-0742 |
| language | English |
| publishDate | 2012-06-01 |
| publisher | BioMed Central |
| record_format | Article |
| series | Genomics & Informatics |
| spelling | doaj-art-743eebf79a8a423baa193d7525dff1dd2025-02-02T22:33:41ZengBioMed CentralGenomics & Informatics1598-866X2234-07422012-06-01102889810.5808/GI.2012.10.2.8838Interaction Effects of Lipoprotein Lipase Polymorphisms with Lifestyle on Lipid Levels in a Korean Population: A Cross-sectional StudyJung-A Pyun0Sunshin Kim1KyungChae Park2Inkyung Baik3Nam H Cho4InSong Koh5Jong-Young Lee6Yoon Shin Cho7Young Jin Kim8Min Jin Go9Eugene Shim10KyuBum Kwack11Chol Shin12Department of Biomedical Science, College of Life Science, CHA University, Seongnam 463-836, Korea.Department of Biomedical Science, College of Life Science, CHA University, Seongnam 463-836, Korea.Department of Family Medicine, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam 463-712, Korea.Department of Foods and Nutrition, College of Natural Sciences, Kookmin University, Seoul 136-702, Korea.Department of Preventive Medicine, Ajou University School of Medicine, Suwon 443-749, Korea.Department of Physiology, Hanyang University College of Medicine, Seoul 133-791, Korea.Center for Genome Science, National Institute of Health, Osong 363-951, Korea.Center for Genome Science, National Institute of Health, Osong 363-951, Korea.Center for Genome Science, National Institute of Health, Osong 363-951, Korea.Center for Genome Science, National Institute of Health, Osong 363-951, Korea.National Hypertension Center, Yonsei University Health System, Seoul 120-752, Korea.Department of Biomedical Science, College of Life Science, CHA University, Seongnam 463-836, Korea.Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Ansan 425-707, Korea.Lipoprotein lipase (LPL) plays an essential role in the regulation of high-density lipoprotein cholesterol (HDLC) and triglyceride levels, which have been closely associated with cardiovascular diseases. Genetic studies in European have shown that LPL single-nucleotide polymorphisms (SNPs) are strongly associated with lipid levels. However, studies about the influence of interactions between LPL SNPs and lifestyle factors have not been sufficiently performed. Here, we examine if LPL polymorphisms, as well as their interaction with lifestyle factors, influence lipid concentrations in a Korean population. A two-stage association study was performed using genotype data for SNPs on the LPL gene, including the 3' flanking region from 7,536 (stage 1) and 3,703 (stage 2) individuals. The association study showed that 15 SNPs and 4 haplotypes were strongly associated with HDLC (lowest p = 2.86 × 10-22) and triglyceride levels (lowest p = 3.0 × 10-15). Interactions between LPL polymorphisms and lifestyle factors (lowest p = 9.6 × 10-4) were also observed on lipid concentrations. These findings suggest that there are interaction effects of LPL polymorphisms with lifestyle variables, including energy intake, fat intake, smoking, and alcohol consumption, as well as effects of LPL polymorphisms themselves, on lipid concentrations in a Korean population.http://genominfo.org/upload/pdf/gni-10-88.pdfinteractionlipoprotein lipaselipoproteinslipidssingle nucleotide polymorphism |
| spellingShingle | Jung-A Pyun Sunshin Kim KyungChae Park Inkyung Baik Nam H Cho InSong Koh Jong-Young Lee Yoon Shin Cho Young Jin Kim Min Jin Go Eugene Shim KyuBum Kwack Chol Shin Interaction Effects of Lipoprotein Lipase Polymorphisms with Lifestyle on Lipid Levels in a Korean Population: A Cross-sectional Study Genomics & Informatics interaction lipoprotein lipase lipoproteins lipids single nucleotide polymorphism |
| title | Interaction Effects of Lipoprotein Lipase Polymorphisms with Lifestyle on Lipid Levels in a Korean Population: A Cross-sectional Study |
| title_full | Interaction Effects of Lipoprotein Lipase Polymorphisms with Lifestyle on Lipid Levels in a Korean Population: A Cross-sectional Study |
| title_fullStr | Interaction Effects of Lipoprotein Lipase Polymorphisms with Lifestyle on Lipid Levels in a Korean Population: A Cross-sectional Study |
| title_full_unstemmed | Interaction Effects of Lipoprotein Lipase Polymorphisms with Lifestyle on Lipid Levels in a Korean Population: A Cross-sectional Study |
| title_short | Interaction Effects of Lipoprotein Lipase Polymorphisms with Lifestyle on Lipid Levels in a Korean Population: A Cross-sectional Study |
| title_sort | interaction effects of lipoprotein lipase polymorphisms with lifestyle on lipid levels in a korean population a cross sectional study |
| topic | interaction lipoprotein lipase lipoproteins lipids single nucleotide polymorphism |
| url | http://genominfo.org/upload/pdf/gni-10-88.pdf |
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