Antineutrophil Cytoplasmic Antibody Induction due to Infection: A Patient with Infective Endocarditis and Chronic Hepatitis C
While antineutrophil cytoplasmic antibody (ANCA) is often used as a diagnostic marker for certain vasculitides, ANCA induction in the setting of infection is much less common. In the case of infective endocarditis, patients may present with multisystem disturbances resembling an autoimmune process,...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2016/3585860 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832547644665233408 |
|---|---|
| author | Fareed B. Kamar T. Lee-Ann Hawkins |
| author_facet | Fareed B. Kamar T. Lee-Ann Hawkins |
| author_sort | Fareed B. Kamar |
| collection | DOAJ |
| description | While antineutrophil cytoplasmic antibody (ANCA) is often used as a diagnostic marker for certain vasculitides, ANCA induction in the setting of infection is much less common. In the case of infective endocarditis, patients may present with multisystem disturbances resembling an autoimmune process, cases that may be rendered even trickier to diagnose in the face of a positive ANCA. Though not always straightforward, distinguishing an infective from an inflammatory process is pivotal in order to guide appropriate therapy. We describe an encounter with a 43-year-old male with chronically untreated hepatitis C virus infection who featured ANCA positivity while hospitalized with acute bacterial endocarditis. His case serves as a reminder of two of the few infections known to uncommonly generate ANCA positivity. We also summarize previously reported cases of ANCA positivity in the context of endocarditis and hepatitis C infections. |
| format | Article |
| id | doaj-art-743cb04e2bcc4b069bc68b7066cc3ef6 |
| institution | Kabale University |
| issn | 1712-9532 1918-1493 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-743cb04e2bcc4b069bc68b7066cc3ef62025-02-03T06:44:00ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1712-95321918-14932016-01-01201610.1155/2016/35858603585860Antineutrophil Cytoplasmic Antibody Induction due to Infection: A Patient with Infective Endocarditis and Chronic Hepatitis CFareed B. Kamar0T. Lee-Ann Hawkins1Department of Medicine, University of Calgary, Calgary, AB, T2N 4N1, CanadaDepartment of Medicine, Division of General Internal Medicine, University of Calgary, Calgary, AB, T2N 4N1, CanadaWhile antineutrophil cytoplasmic antibody (ANCA) is often used as a diagnostic marker for certain vasculitides, ANCA induction in the setting of infection is much less common. In the case of infective endocarditis, patients may present with multisystem disturbances resembling an autoimmune process, cases that may be rendered even trickier to diagnose in the face of a positive ANCA. Though not always straightforward, distinguishing an infective from an inflammatory process is pivotal in order to guide appropriate therapy. We describe an encounter with a 43-year-old male with chronically untreated hepatitis C virus infection who featured ANCA positivity while hospitalized with acute bacterial endocarditis. His case serves as a reminder of two of the few infections known to uncommonly generate ANCA positivity. We also summarize previously reported cases of ANCA positivity in the context of endocarditis and hepatitis C infections.http://dx.doi.org/10.1155/2016/3585860 |
| spellingShingle | Fareed B. Kamar T. Lee-Ann Hawkins Antineutrophil Cytoplasmic Antibody Induction due to Infection: A Patient with Infective Endocarditis and Chronic Hepatitis C Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | Antineutrophil Cytoplasmic Antibody Induction due to Infection: A Patient with Infective Endocarditis and Chronic Hepatitis C |
| title_full | Antineutrophil Cytoplasmic Antibody Induction due to Infection: A Patient with Infective Endocarditis and Chronic Hepatitis C |
| title_fullStr | Antineutrophil Cytoplasmic Antibody Induction due to Infection: A Patient with Infective Endocarditis and Chronic Hepatitis C |
| title_full_unstemmed | Antineutrophil Cytoplasmic Antibody Induction due to Infection: A Patient with Infective Endocarditis and Chronic Hepatitis C |
| title_short | Antineutrophil Cytoplasmic Antibody Induction due to Infection: A Patient with Infective Endocarditis and Chronic Hepatitis C |
| title_sort | antineutrophil cytoplasmic antibody induction due to infection a patient with infective endocarditis and chronic hepatitis c |
| url | http://dx.doi.org/10.1155/2016/3585860 |
| work_keys_str_mv | AT fareedbkamar antineutrophilcytoplasmicantibodyinductionduetoinfectionapatientwithinfectiveendocarditisandchronichepatitisc AT tleeannhawkins antineutrophilcytoplasmicantibodyinductionduetoinfectionapatientwithinfectiveendocarditisandchronichepatitisc |