Bicarbonates for the Prevention of Postoperative Renal Failure in Endovascular Aortic Aneurysm Repair: A Randomized Pilot Trial
Purpose. Contrast-induced nephropathy (CIN) can contribute to acute kidney injury (AKI) in patients undergoing endovascular aortic aneurysm surgery. We evaluated the incidence of AKI together with the evolution of early biomarkers of renal injury in patients receiving bicarbonates or NaCl 0.9%. Meth...
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Wiley
2013-01-01
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| Series: | Anesthesiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2013/467326 |
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| author | Véronique Brulotte François A. Leblond Stéphane Elkouri Éric Thérasse Vincent Pichette Pierre Beaulieu |
| author_facet | Véronique Brulotte François A. Leblond Stéphane Elkouri Éric Thérasse Vincent Pichette Pierre Beaulieu |
| author_sort | Véronique Brulotte |
| collection | DOAJ |
| description | Purpose. Contrast-induced nephropathy (CIN) can contribute to acute kidney injury (AKI) in patients undergoing endovascular aortic aneurysm surgery. We evaluated the incidence of AKI together with the evolution of early biomarkers of renal injury in patients receiving bicarbonates or NaCl 0.9%. Methods. This study involved endovascular aortic aneurysm surgery patients. Group A (n=17) received bicarbonates 3 mL/kg/h for 1 h before the procedure and then 1 mL/kg/h until 6 h after surgery, whereas group B (n=17) received NaCl 0.9% using the same protocol. Biomarkers of renal injury from urine (interleukin-18 (IL-18), neutrophil gelatinase-associated lipocalin (NGAL), N-acetyl-β-D-glucosaminidase (NAG), and kidney injury molecule 1 (KIM-1)) and blood (NGAL, cystatin C) were measured at baseline and 3, 24, and 48 h postoperatively. Results. AKI occurred in 1 patient (2.9%), in the bicarbonates group. IL-18, NAG, NGAL, and KIM-1 significantly rose in both groups after the surgery. There was a greater rise in NGAL and IL-18 after 3 h in the bicarbonates versus NaCl 0.9% group: 1115% versus 240% increase (P=0.03) and 338% increase versus 1.4% decrease (P=0.01). Conclusions. Despite significant elevation in biomarkers of renal injury, we demonstrated a low rate of AKI following endovascular aortic surgery. |
| format | Article |
| id | doaj-art-743b93b2a2814bf08fd247ce118018e8 |
| institution | Kabale University |
| issn | 1687-6962 1687-6970 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Anesthesiology Research and Practice |
| spelling | doaj-art-743b93b2a2814bf08fd247ce118018e82025-02-03T01:33:25ZengWileyAnesthesiology Research and Practice1687-69621687-69702013-01-01201310.1155/2013/467326467326Bicarbonates for the Prevention of Postoperative Renal Failure in Endovascular Aortic Aneurysm Repair: A Randomized Pilot TrialVéronique Brulotte0François A. Leblond1Stéphane Elkouri2Éric Thérasse3Vincent Pichette4Pierre Beaulieu5Anesthesiology Department, University of Montreal Hospital Centre, 3840 St. Urbain Street, Montréal, QC, H2W 1T8, CanadaNephrology Department and Guy-Bernier Research Centre, Maisonneuve-Rosemont Hospital, CanadaVascular Surgery Department, University of Montreal Hospital Centre, 3840 St. Urbain Street, Montréal, QC, H2W 1T8, CanadaRadiology Department, University of Montreal Hospital Centre, 3840 St. Urbain Street, Montréal, QC, H2W 1T8, CanadaNephrology Department and Guy-Bernier Research Centre, Maisonneuve-Rosemont Hospital, CanadaAnesthesiology Department, University of Montreal Hospital Centre, 3840 St. Urbain Street, Montréal, QC, H2W 1T8, CanadaPurpose. Contrast-induced nephropathy (CIN) can contribute to acute kidney injury (AKI) in patients undergoing endovascular aortic aneurysm surgery. We evaluated the incidence of AKI together with the evolution of early biomarkers of renal injury in patients receiving bicarbonates or NaCl 0.9%. Methods. This study involved endovascular aortic aneurysm surgery patients. Group A (n=17) received bicarbonates 3 mL/kg/h for 1 h before the procedure and then 1 mL/kg/h until 6 h after surgery, whereas group B (n=17) received NaCl 0.9% using the same protocol. Biomarkers of renal injury from urine (interleukin-18 (IL-18), neutrophil gelatinase-associated lipocalin (NGAL), N-acetyl-β-D-glucosaminidase (NAG), and kidney injury molecule 1 (KIM-1)) and blood (NGAL, cystatin C) were measured at baseline and 3, 24, and 48 h postoperatively. Results. AKI occurred in 1 patient (2.9%), in the bicarbonates group. IL-18, NAG, NGAL, and KIM-1 significantly rose in both groups after the surgery. There was a greater rise in NGAL and IL-18 after 3 h in the bicarbonates versus NaCl 0.9% group: 1115% versus 240% increase (P=0.03) and 338% increase versus 1.4% decrease (P=0.01). Conclusions. Despite significant elevation in biomarkers of renal injury, we demonstrated a low rate of AKI following endovascular aortic surgery.http://dx.doi.org/10.1155/2013/467326 |
| spellingShingle | Véronique Brulotte François A. Leblond Stéphane Elkouri Éric Thérasse Vincent Pichette Pierre Beaulieu Bicarbonates for the Prevention of Postoperative Renal Failure in Endovascular Aortic Aneurysm Repair: A Randomized Pilot Trial Anesthesiology Research and Practice |
| title | Bicarbonates for the Prevention of Postoperative Renal Failure in Endovascular Aortic Aneurysm Repair: A Randomized Pilot Trial |
| title_full | Bicarbonates for the Prevention of Postoperative Renal Failure in Endovascular Aortic Aneurysm Repair: A Randomized Pilot Trial |
| title_fullStr | Bicarbonates for the Prevention of Postoperative Renal Failure in Endovascular Aortic Aneurysm Repair: A Randomized Pilot Trial |
| title_full_unstemmed | Bicarbonates for the Prevention of Postoperative Renal Failure in Endovascular Aortic Aneurysm Repair: A Randomized Pilot Trial |
| title_short | Bicarbonates for the Prevention of Postoperative Renal Failure in Endovascular Aortic Aneurysm Repair: A Randomized Pilot Trial |
| title_sort | bicarbonates for the prevention of postoperative renal failure in endovascular aortic aneurysm repair a randomized pilot trial |
| url | http://dx.doi.org/10.1155/2013/467326 |
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