Obstacles, research progress, and prospects of oral delivery of bioactive peptides: a comprehensive review
Bioactive peptides hold significant potential for enhancing human health, however, their limited oral bioavailability poses a substantial barrier to their widespread use in the food and pharmaceutical industries. This article reviews the key factors influencing the absorption efficiency of oral bioa...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2024.1496706/full |
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| author | Xinyu Wang Zeyao Yang Wangang Zhang Lujuan Xing Ruiming Luo Songmin Cao |
| author_facet | Xinyu Wang Zeyao Yang Wangang Zhang Lujuan Xing Ruiming Luo Songmin Cao |
| author_sort | Xinyu Wang |
| collection | DOAJ |
| description | Bioactive peptides hold significant potential for enhancing human health, however, their limited oral bioavailability poses a substantial barrier to their widespread use in the food and pharmaceutical industries. This article reviews the key factors influencing the absorption efficiency of oral bioactive peptides, including issues related to bitter taste perception, challenges in gastrointestinal environmental stability, and limitations in transmembrane transport. Furthermore, it highlights the latest technologies, such as osmotic technology, chemical modification, and advanced delivery systems, and discusses their advantages in enhancing the stability of bioactive peptides and facilitating intestinal absorption. In addition, the application and challenges of common delivery systems such as liposomes, emulsions, polymer nanoparticles, and hydrogels in oral bioactive peptide delivery are also discussed. This paper aims to provide a theoretical foundation for scientific research and practical applications of oral delivery of bioactive peptides, thereby promoting the further development of bioactive peptides in the context of human health. |
| format | Article |
| id | doaj-art-74367e398a404b2c8b06e349fe5e04b7 |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-74367e398a404b2c8b06e349fe5e04b72025-01-28T10:07:26ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2024-11-011110.3389/fnut.2024.14967061496706Obstacles, research progress, and prospects of oral delivery of bioactive peptides: a comprehensive reviewXinyu Wang0Zeyao Yang1Wangang Zhang2Lujuan Xing3Ruiming Luo4Songmin Cao5School of Food Science and Engineering, Ningxia University, Yinchuan, ChinaSchool of Food Science and Engineering, Ningxia University, Yinchuan, ChinaKey Lab of Meat Processing and Quality Control, MOE, School of Food Science and Technology, Nanjing Agricultural University, Nanjing, ChinaKey Lab of Meat Processing and Quality Control, MOE, School of Food Science and Technology, Nanjing Agricultural University, Nanjing, ChinaSchool of Food Science and Engineering, Ningxia University, Yinchuan, ChinaSchool of Food Science and Engineering, Ningxia University, Yinchuan, ChinaBioactive peptides hold significant potential for enhancing human health, however, their limited oral bioavailability poses a substantial barrier to their widespread use in the food and pharmaceutical industries. This article reviews the key factors influencing the absorption efficiency of oral bioactive peptides, including issues related to bitter taste perception, challenges in gastrointestinal environmental stability, and limitations in transmembrane transport. Furthermore, it highlights the latest technologies, such as osmotic technology, chemical modification, and advanced delivery systems, and discusses their advantages in enhancing the stability of bioactive peptides and facilitating intestinal absorption. In addition, the application and challenges of common delivery systems such as liposomes, emulsions, polymer nanoparticles, and hydrogels in oral bioactive peptide delivery are also discussed. This paper aims to provide a theoretical foundation for scientific research and practical applications of oral delivery of bioactive peptides, thereby promoting the further development of bioactive peptides in the context of human health.https://www.frontiersin.org/articles/10.3389/fnut.2024.1496706/fullbioactive peptidesoral administrationbioavailabilityoral delivery systemspeptide transport |
| spellingShingle | Xinyu Wang Zeyao Yang Wangang Zhang Lujuan Xing Ruiming Luo Songmin Cao Obstacles, research progress, and prospects of oral delivery of bioactive peptides: a comprehensive review Frontiers in Nutrition bioactive peptides oral administration bioavailability oral delivery systems peptide transport |
| title | Obstacles, research progress, and prospects of oral delivery of bioactive peptides: a comprehensive review |
| title_full | Obstacles, research progress, and prospects of oral delivery of bioactive peptides: a comprehensive review |
| title_fullStr | Obstacles, research progress, and prospects of oral delivery of bioactive peptides: a comprehensive review |
| title_full_unstemmed | Obstacles, research progress, and prospects of oral delivery of bioactive peptides: a comprehensive review |
| title_short | Obstacles, research progress, and prospects of oral delivery of bioactive peptides: a comprehensive review |
| title_sort | obstacles research progress and prospects of oral delivery of bioactive peptides a comprehensive review |
| topic | bioactive peptides oral administration bioavailability oral delivery systems peptide transport |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2024.1496706/full |
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