Clinical Characterization of Patients with Chronic Spontaneous Urticaria according to Anti-TPO IgE Levels
Background. Chronic spontaneous urticaria (CSU) is a heterogeneous disease with some frequent comorbidities like autoimmune diseases, drug reactions, and inducible urticaria. IgE antibodies against thyroid peroxidase (anti-TPO IgE) could be associated with some of these clinical characteristics. Obj...
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Wiley
2019-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2019/4202145 |
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| author | Jorge Sánchez Andres Sánchez Ricardo Cardona |
| author_facet | Jorge Sánchez Andres Sánchez Ricardo Cardona |
| author_sort | Jorge Sánchez |
| collection | DOAJ |
| description | Background. Chronic spontaneous urticaria (CSU) is a heterogeneous disease with some frequent comorbidities like autoimmune diseases, drug reactions, and inducible urticaria. IgE antibodies against thyroid peroxidase (anti-TPO IgE) could be associated with some of these clinical characteristics. Objective. To explore the clinical characteristics of CSU patients, according to the presence of anti-TPO IgE in serum. Methods. Anti-TPO IgE levels were measured during the clinical control period (Urticaria Activity Score, 0 point) and exacerbation period (≥3 points) in 100 CSU patients. Patients with self-reported exacerbation of skin involvement by foods, nonsteroidal anti-inflammatory drugs (NSAIDs), and physical triggers underwent controlled challenge tests. Results. We identified 2 groups of patients: (1) patients with anti-TPO IgE during the clinical control period or during an exacerbation, who had a higher frequency of atopy, asthma, and positive challenge test results with NSAIDs and (2) patients without anti-TPO IgE during any period, who had a higher frequency of positive challenge test results for inducible urticaria. Among the first group (anti-TPO IgE at any point), we identified 3 subgroups: patients with anti-TPO IgE during the clinical control period (n=12); patients with anti-TPO IgE during the clinical control period and significantly increased levels during an urticaria exacerbation (n=18); and patients with anti-TPO IgE only during an exacerbation (n=13). None of the patients with self-reported food reactions had a positive challenge test result. Conclusion. Anti-TPO IgE is a useful biomarker for differentiating between clinical phenotypes of patients with CSU. Elevation of anti-TPO IgE during exacerbation periods supports an association between this autoantibody and the pathogenesis of urticaria. |
| format | Article |
| id | doaj-art-7427fe19a87e44ba95284a85e1e5e409 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-7427fe19a87e44ba95284a85e1e5e4092025-02-03T01:10:06ZengWileyJournal of Immunology Research2314-88612314-71562019-01-01201910.1155/2019/42021454202145Clinical Characterization of Patients with Chronic Spontaneous Urticaria according to Anti-TPO IgE LevelsJorge Sánchez0Andres Sánchez1Ricardo Cardona2Group of Experimental and Clinical Allergy, Foundation “IPS Universitaria”, University of Antioquia, Medellín, ColombiaGroup of Experimental and Clinical Allergy, Foundation “IPS Universitaria”, University of Antioquia, Medellín, ColombiaGroup of Experimental and Clinical Allergy, Foundation “IPS Universitaria”, University of Antioquia, Medellín, ColombiaBackground. Chronic spontaneous urticaria (CSU) is a heterogeneous disease with some frequent comorbidities like autoimmune diseases, drug reactions, and inducible urticaria. IgE antibodies against thyroid peroxidase (anti-TPO IgE) could be associated with some of these clinical characteristics. Objective. To explore the clinical characteristics of CSU patients, according to the presence of anti-TPO IgE in serum. Methods. Anti-TPO IgE levels were measured during the clinical control period (Urticaria Activity Score, 0 point) and exacerbation period (≥3 points) in 100 CSU patients. Patients with self-reported exacerbation of skin involvement by foods, nonsteroidal anti-inflammatory drugs (NSAIDs), and physical triggers underwent controlled challenge tests. Results. We identified 2 groups of patients: (1) patients with anti-TPO IgE during the clinical control period or during an exacerbation, who had a higher frequency of atopy, asthma, and positive challenge test results with NSAIDs and (2) patients without anti-TPO IgE during any period, who had a higher frequency of positive challenge test results for inducible urticaria. Among the first group (anti-TPO IgE at any point), we identified 3 subgroups: patients with anti-TPO IgE during the clinical control period (n=12); patients with anti-TPO IgE during the clinical control period and significantly increased levels during an urticaria exacerbation (n=18); and patients with anti-TPO IgE only during an exacerbation (n=13). None of the patients with self-reported food reactions had a positive challenge test result. Conclusion. Anti-TPO IgE is a useful biomarker for differentiating between clinical phenotypes of patients with CSU. Elevation of anti-TPO IgE during exacerbation periods supports an association between this autoantibody and the pathogenesis of urticaria.http://dx.doi.org/10.1155/2019/4202145 |
| spellingShingle | Jorge Sánchez Andres Sánchez Ricardo Cardona Clinical Characterization of Patients with Chronic Spontaneous Urticaria according to Anti-TPO IgE Levels Journal of Immunology Research |
| title | Clinical Characterization of Patients with Chronic Spontaneous Urticaria according to Anti-TPO IgE Levels |
| title_full | Clinical Characterization of Patients with Chronic Spontaneous Urticaria according to Anti-TPO IgE Levels |
| title_fullStr | Clinical Characterization of Patients with Chronic Spontaneous Urticaria according to Anti-TPO IgE Levels |
| title_full_unstemmed | Clinical Characterization of Patients with Chronic Spontaneous Urticaria according to Anti-TPO IgE Levels |
| title_short | Clinical Characterization of Patients with Chronic Spontaneous Urticaria according to Anti-TPO IgE Levels |
| title_sort | clinical characterization of patients with chronic spontaneous urticaria according to anti tpo ige levels |
| url | http://dx.doi.org/10.1155/2019/4202145 |
| work_keys_str_mv | AT jorgesanchez clinicalcharacterizationofpatientswithchronicspontaneousurticariaaccordingtoantitpoigelevels AT andressanchez clinicalcharacterizationofpatientswithchronicspontaneousurticariaaccordingtoantitpoigelevels AT ricardocardona clinicalcharacterizationofpatientswithchronicspontaneousurticariaaccordingtoantitpoigelevels |