Association Between Nontraditional Lipid Profiles and the Risk of Type 2 Diabetes Mellitus in Chinese Adults With Hypertension: Findings From the China Hypertension Registry Study
ABSTRACT The relationship between nontraditional lipid profiles and type 2 diabetes mellitus (T2DM) remains ambiguous within the hypertension population. The objective of this study is to examine the association between nontraditional lipid profiles and T2DM in Chinese adults with hypertension. The...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | The Journal of Clinical Hypertension |
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| Online Access: | https://doi.org/10.1111/jch.14927 |
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| author | Yu Tao Tao Wang Wei Zhou Lingjuan Zhu Chao Yu Juxiang Li Huihui Bao Xiaoshu Cheng |
| author_facet | Yu Tao Tao Wang Wei Zhou Lingjuan Zhu Chao Yu Juxiang Li Huihui Bao Xiaoshu Cheng |
| author_sort | Yu Tao |
| collection | DOAJ |
| description | ABSTRACT The relationship between nontraditional lipid profiles and type 2 diabetes mellitus (T2DM) remains ambiguous within the hypertension population. The objective of this study is to examine the association between nontraditional lipid profiles and T2DM in Chinese adults with hypertension. The current investigation encompassed 13 728 participants with hypertension from the China Hypertension Registry Study. Logistic regression analysis and smooth curve fitting were employed to evaluate the association between nontraditional lipid profiles and T2DM. The prevalence of T2DM was found to be 17.8%. In the fully adjusted model, atherogenic index of plasma (AIP) exhibited the highest odds ratios (ORs) for T2DM (OR: 2.71, 95% confidence interval [CI]: 2.26–3.26). Conversely, the fully adjusted ORs (95% CI) for total cholesterol (TC)/high‐density lipoprotein cholesterol (HDL‐C), low‐density lipoprotein cholesterol (LDL‐C)/HDL‐C, and non‐high‐density lipoprotein cholesterol (Non‐HDL‐C) were 1.33 (1.25–1.41), 1.40 (1.29–1.51), and 1.41 (1.34–1.49), respectively. Additionally, the study demonstrated that AIP had a superior ability to identify T2DM. Subgroup analyses indicated that the relationship between AIP and Non‐HDL‐C with T2DM was more significant in the lighter weight population. In addition, the association of TC/HDL‐C with LDL‐C/HDL‐C with T2DM was stronger in the lower homocysteine level population. Among the southern Chinese population with hypertension, all nontraditional lipid indices positively correlated with the risk of T2DM. Among these lipid indices, AIP exhibited superior discriminatory power in identifying T2DM compared to TC/HDL‐C, LDL‐C/HDL‐C. Trial Registration: ChiCTR1800017274 |
| format | Article |
| id | doaj-art-7426c6f09b0541a4ab290e51bb4fa0e4 |
| institution | Kabale University |
| issn | 1524-6175 1751-7176 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
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| series | The Journal of Clinical Hypertension |
| spelling | doaj-art-7426c6f09b0541a4ab290e51bb4fa0e42025-01-31T05:38:36ZengWileyThe Journal of Clinical Hypertension1524-61751751-71762025-01-01271n/an/a10.1111/jch.14927Association Between Nontraditional Lipid Profiles and the Risk of Type 2 Diabetes Mellitus in Chinese Adults With Hypertension: Findings From the China Hypertension Registry StudyYu Tao0Tao Wang1Wei Zhou2Lingjuan Zhu3Chao Yu4Juxiang Li5Huihui Bao6Xiaoshu Cheng7Department of Cardiovascular Medicine the Second Affiliated Hospital of Nanchang University Nanchang Jiangxi ChinaJiangxi Provincial Cardiovascular Disease Clinical Medical Research Center Nanchang Jiangxi ChinaJiangxi Provincial Cardiovascular Disease Clinical Medical Research Center Nanchang Jiangxi ChinaJiangxi Provincial Cardiovascular Disease Clinical Medical Research Center Nanchang Jiangxi ChinaJiangxi Provincial Cardiovascular Disease Clinical Medical Research Center Nanchang Jiangxi ChinaDepartment of Cardiovascular Medicine the Second Affiliated Hospital of Nanchang University Nanchang Jiangxi ChinaDepartment of Cardiovascular Medicine the Second Affiliated Hospital of Nanchang University Nanchang Jiangxi ChinaDepartment of Cardiovascular Medicine the Second Affiliated Hospital of Nanchang University Nanchang Jiangxi ChinaABSTRACT The relationship between nontraditional lipid profiles and type 2 diabetes mellitus (T2DM) remains ambiguous within the hypertension population. The objective of this study is to examine the association between nontraditional lipid profiles and T2DM in Chinese adults with hypertension. The current investigation encompassed 13 728 participants with hypertension from the China Hypertension Registry Study. Logistic regression analysis and smooth curve fitting were employed to evaluate the association between nontraditional lipid profiles and T2DM. The prevalence of T2DM was found to be 17.8%. In the fully adjusted model, atherogenic index of plasma (AIP) exhibited the highest odds ratios (ORs) for T2DM (OR: 2.71, 95% confidence interval [CI]: 2.26–3.26). Conversely, the fully adjusted ORs (95% CI) for total cholesterol (TC)/high‐density lipoprotein cholesterol (HDL‐C), low‐density lipoprotein cholesterol (LDL‐C)/HDL‐C, and non‐high‐density lipoprotein cholesterol (Non‐HDL‐C) were 1.33 (1.25–1.41), 1.40 (1.29–1.51), and 1.41 (1.34–1.49), respectively. Additionally, the study demonstrated that AIP had a superior ability to identify T2DM. Subgroup analyses indicated that the relationship between AIP and Non‐HDL‐C with T2DM was more significant in the lighter weight population. In addition, the association of TC/HDL‐C with LDL‐C/HDL‐C with T2DM was stronger in the lower homocysteine level population. Among the southern Chinese population with hypertension, all nontraditional lipid indices positively correlated with the risk of T2DM. Among these lipid indices, AIP exhibited superior discriminatory power in identifying T2DM compared to TC/HDL‐C, LDL‐C/HDL‐C. Trial Registration: ChiCTR1800017274https://doi.org/10.1111/jch.14927atherogenic index of plasmahypertensionnontraditional lipid profilestype 2 diabetes mellitus |
| spellingShingle | Yu Tao Tao Wang Wei Zhou Lingjuan Zhu Chao Yu Juxiang Li Huihui Bao Xiaoshu Cheng Association Between Nontraditional Lipid Profiles and the Risk of Type 2 Diabetes Mellitus in Chinese Adults With Hypertension: Findings From the China Hypertension Registry Study The Journal of Clinical Hypertension atherogenic index of plasma hypertension nontraditional lipid profiles type 2 diabetes mellitus |
| title | Association Between Nontraditional Lipid Profiles and the Risk of Type 2 Diabetes Mellitus in Chinese Adults With Hypertension: Findings From the China Hypertension Registry Study |
| title_full | Association Between Nontraditional Lipid Profiles and the Risk of Type 2 Diabetes Mellitus in Chinese Adults With Hypertension: Findings From the China Hypertension Registry Study |
| title_fullStr | Association Between Nontraditional Lipid Profiles and the Risk of Type 2 Diabetes Mellitus in Chinese Adults With Hypertension: Findings From the China Hypertension Registry Study |
| title_full_unstemmed | Association Between Nontraditional Lipid Profiles and the Risk of Type 2 Diabetes Mellitus in Chinese Adults With Hypertension: Findings From the China Hypertension Registry Study |
| title_short | Association Between Nontraditional Lipid Profiles and the Risk of Type 2 Diabetes Mellitus in Chinese Adults With Hypertension: Findings From the China Hypertension Registry Study |
| title_sort | association between nontraditional lipid profiles and the risk of type 2 diabetes mellitus in chinese adults with hypertension findings from the china hypertension registry study |
| topic | atherogenic index of plasma hypertension nontraditional lipid profiles type 2 diabetes mellitus |
| url | https://doi.org/10.1111/jch.14927 |
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