Are Trace Elements Provided for Children on Long-Term Parenteral Nutrition Adequate to Meet Their Needs?
<b>Background</b>: We conducted a cross-sectional study to investigate whether children receiving long-term parenteral nutrition (LPN) are at risk of imbalances in selected trace elements. <b>Methods</b>: Serum levels of manganese, zinc, copper, selenium, and iodine were meas...
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2024-12-01
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| author | Hanna Romanowska Mikołaj Danko Anna Borkowska Katarzyna Popińska Marta Sibilska Joanna Żydak Joanna Wielopolska Klaudia Bartoszewicz Agnieszka Szlagatys-Sidorkiewicz Janusz Książyk |
| author_facet | Hanna Romanowska Mikołaj Danko Anna Borkowska Katarzyna Popińska Marta Sibilska Joanna Żydak Joanna Wielopolska Klaudia Bartoszewicz Agnieszka Szlagatys-Sidorkiewicz Janusz Książyk |
| author_sort | Hanna Romanowska |
| collection | DOAJ |
| description | <b>Background</b>: We conducted a cross-sectional study to investigate whether children receiving long-term parenteral nutrition (LPN) are at risk of imbalances in selected trace elements. <b>Methods</b>: Serum levels of manganese, zinc, copper, selenium, and iodine were measured in 83 children on LPN and compared with 121 healthy controls. Children with signs of infection or elevated C-reactive protein levels were excluded. Elemental analysis was performed using inductively coupled plasma mass spectrometry (ICP-MS). <b>Results</b>: Manganese and copper levels were significantly lower in the study group compared with controls (<i>p</i> < 0.001) but remained within normal ranges. Iodine levels were also significantly lower in the study group (<i>p</i> < 0.05), though pediatric reference values are lacking. Zinc and selenium levels were significantly higher in the study group (<i>p</i> < 0.001), with median levels within normal ranges in both groups. Zinc, selenium, and iodine levels were higher in patients weighing ≤15 kg (<i>p</i> < 0.001, <i>p</i> < 0.001, <i>p</i> < 0.02). <b>Conclusions</b>: Serum concentrations of manganese, copper, and selenium in the study group remained within normal ranges, even though children weighing over 15 kg received doses below those recommended by scientific guidelines. An iodine intake below 1 μg/kg/day in patients weighing over 15 kg appears insufficient. Patients on LPN required a higher zinc intake than current recommendations. |
| format | Article |
| id | doaj-art-7421dfb5270040c6b7b548a939a215dc |
| institution | Kabale University |
| issn | 2075-1729 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj-art-7421dfb5270040c6b7b548a939a215dc2025-01-24T13:38:30ZengMDPI AGLife2075-17292024-12-011512910.3390/life15010029Are Trace Elements Provided for Children on Long-Term Parenteral Nutrition Adequate to Meet Their Needs?Hanna Romanowska0Mikołaj Danko1Anna Borkowska2Katarzyna Popińska3Marta Sibilska4Joanna Żydak5Joanna Wielopolska6Klaudia Bartoszewicz7Agnieszka Szlagatys-Sidorkiewicz8Janusz Książyk9Department of Pediatrics, Endocrinology, Diabetology, Metabolic Diseases and Cardiology of the Developmental Age, Pomeranian Medical University, 71-252 Szczecin, PolandThe Children’s Memorial Health Institute, Department of Pediatrics, Nutrition and Metabolic Diseases, 04-730 Warsaw, PolandDepartment of Pediatrics, Gastroenterology, Allergology and Nutrition, Medical University of Gdańsk, 80-803 Gdańsk, PolandThe Children’s Memorial Health Institute, Department of Pediatrics, Nutrition and Metabolic Diseases, 04-730 Warsaw, PolandThe Children’s Memorial Health Institute, Department of Pediatrics, Nutrition and Metabolic Diseases, 04-730 Warsaw, PolandThe Children’s Memorial Health Institute, Department of Pediatrics, Nutrition and Metabolic Diseases, 04-730 Warsaw, PolandDepartment of Pediatrics, Endocrinology, Diabetology, Metabolic Diseases and Cardiology of the Developmental Age, Pomeranian Medical University, 71-252 Szczecin, PolandDepartment of Pediatrics, Endocrinology, Diabetology, Metabolic Diseases and Cardiology of the Developmental Age, Pomeranian Medical University, 71-252 Szczecin, PolandDepartment of Pediatrics, Gastroenterology, Allergology and Nutrition, Medical University of Gdańsk, 80-803 Gdańsk, PolandThe Children’s Memorial Health Institute, Department of Pediatrics, Nutrition and Metabolic Diseases, 04-730 Warsaw, Poland<b>Background</b>: We conducted a cross-sectional study to investigate whether children receiving long-term parenteral nutrition (LPN) are at risk of imbalances in selected trace elements. <b>Methods</b>: Serum levels of manganese, zinc, copper, selenium, and iodine were measured in 83 children on LPN and compared with 121 healthy controls. Children with signs of infection or elevated C-reactive protein levels were excluded. Elemental analysis was performed using inductively coupled plasma mass spectrometry (ICP-MS). <b>Results</b>: Manganese and copper levels were significantly lower in the study group compared with controls (<i>p</i> < 0.001) but remained within normal ranges. Iodine levels were also significantly lower in the study group (<i>p</i> < 0.05), though pediatric reference values are lacking. Zinc and selenium levels were significantly higher in the study group (<i>p</i> < 0.001), with median levels within normal ranges in both groups. Zinc, selenium, and iodine levels were higher in patients weighing ≤15 kg (<i>p</i> < 0.001, <i>p</i> < 0.001, <i>p</i> < 0.02). <b>Conclusions</b>: Serum concentrations of manganese, copper, and selenium in the study group remained within normal ranges, even though children weighing over 15 kg received doses below those recommended by scientific guidelines. An iodine intake below 1 μg/kg/day in patients weighing over 15 kg appears insufficient. Patients on LPN required a higher zinc intake than current recommendations.https://www.mdpi.com/2075-1729/15/1/29childrenparenteral nutritiontrace elementscross-sectional study |
| spellingShingle | Hanna Romanowska Mikołaj Danko Anna Borkowska Katarzyna Popińska Marta Sibilska Joanna Żydak Joanna Wielopolska Klaudia Bartoszewicz Agnieszka Szlagatys-Sidorkiewicz Janusz Książyk Are Trace Elements Provided for Children on Long-Term Parenteral Nutrition Adequate to Meet Their Needs? Life children parenteral nutrition trace elements cross-sectional study |
| title | Are Trace Elements Provided for Children on Long-Term Parenteral Nutrition Adequate to Meet Their Needs? |
| title_full | Are Trace Elements Provided for Children on Long-Term Parenteral Nutrition Adequate to Meet Their Needs? |
| title_fullStr | Are Trace Elements Provided for Children on Long-Term Parenteral Nutrition Adequate to Meet Their Needs? |
| title_full_unstemmed | Are Trace Elements Provided for Children on Long-Term Parenteral Nutrition Adequate to Meet Their Needs? |
| title_short | Are Trace Elements Provided for Children on Long-Term Parenteral Nutrition Adequate to Meet Their Needs? |
| title_sort | are trace elements provided for children on long term parenteral nutrition adequate to meet their needs |
| topic | children parenteral nutrition trace elements cross-sectional study |
| url | https://www.mdpi.com/2075-1729/15/1/29 |
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