Production of Toxic Volatile Trimethylbismuth by the Intestinal Microbiota of Mice
The biotransformation of metals and metalloids into their volatile methylated derivatives by microbes growing under anaerobic conditions (e.g., the mammalian intestinal microbiota) plays an important role in spreading these compounds in the environment. In this paper, we could show that the presence...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2011/491039 |
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| author | Britta Huber Philip Dammann Christine Krüger Petra Kirsch Beatrix Bialek Roland A. Diaz-Bone Reinhard Hensel |
| author_facet | Britta Huber Philip Dammann Christine Krüger Petra Kirsch Beatrix Bialek Roland A. Diaz-Bone Reinhard Hensel |
| author_sort | Britta Huber |
| collection | DOAJ |
| description | The biotransformation of metals and metalloids into their volatile methylated derivatives by microbes growing under anaerobic conditions (e.g., the mammalian intestinal microbiota) plays an important role in spreading these compounds in the environment. In this paper, we could show that the presence of an intact intestinal microbiota of mice provides the conditio sine qua non for the production of these mostly toxic derivatives. To document the indispensible role of the intestinal microbiota in methylating metals and metalloids to volatile derivatives under in vivo conditions, we compared the methylation capability of conventionally raised (CONV) and germ-free (GF) B6-mice fed with chow containing colloidal bismuth subcitrate (CBS) as the starting material for the formation of volatile methylated metal(loid)s. Permethylated volatile trimethylbismuth ((CH3)3Bi) was only detected in the blood of the conventionally raised mice. Concomitantly, a higher bismuth concentration was found in organs such as liver, lung, testicles, and brain of the CONV mice as compared to those of GF mice (P>0.01), strongly suggesting a correlation between the intestinal biomethylation of bismuth and its accumulation in mammalian tissues. |
| format | Article |
| id | doaj-art-73e2b22e3b374a5bb92b88618170ca90 |
| institution | Kabale University |
| issn | 1687-8191 1687-8205 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-73e2b22e3b374a5bb92b88618170ca902025-02-03T05:49:37ZengWileyJournal of Toxicology1687-81911687-82052011-01-01201110.1155/2011/491039491039Production of Toxic Volatile Trimethylbismuth by the Intestinal Microbiota of MiceBritta Huber0Philip Dammann1Christine Krüger2Petra Kirsch3Beatrix Bialek4Roland A. Diaz-Bone5Reinhard Hensel6Department of Microbioloy I, University of Duisburg-Essen, UniversitaetsstraBe 2, 45141 Essen, GermanyCentral Animal Laboratory, University Hospital Essen, HufelandstraBe 55, 45122 Essen, GermanyCentral Animal Laboratory, University Hospital Essen, HufelandstraBe 55, 45122 Essen, GermanyAnimal Research Center, University of Ulm, Oberberghof, 89081 Ulm, GermanyDepartment of Microbioloy I, University of Duisburg-Essen, UniversitaetsstraBe 2, 45141 Essen, GermanyDepartment of Microbioloy I, University of Duisburg-Essen, UniversitaetsstraBe 2, 45141 Essen, GermanyDepartment of Microbioloy I, University of Duisburg-Essen, UniversitaetsstraBe 2, 45141 Essen, GermanyThe biotransformation of metals and metalloids into their volatile methylated derivatives by microbes growing under anaerobic conditions (e.g., the mammalian intestinal microbiota) plays an important role in spreading these compounds in the environment. In this paper, we could show that the presence of an intact intestinal microbiota of mice provides the conditio sine qua non for the production of these mostly toxic derivatives. To document the indispensible role of the intestinal microbiota in methylating metals and metalloids to volatile derivatives under in vivo conditions, we compared the methylation capability of conventionally raised (CONV) and germ-free (GF) B6-mice fed with chow containing colloidal bismuth subcitrate (CBS) as the starting material for the formation of volatile methylated metal(loid)s. Permethylated volatile trimethylbismuth ((CH3)3Bi) was only detected in the blood of the conventionally raised mice. Concomitantly, a higher bismuth concentration was found in organs such as liver, lung, testicles, and brain of the CONV mice as compared to those of GF mice (P>0.01), strongly suggesting a correlation between the intestinal biomethylation of bismuth and its accumulation in mammalian tissues.http://dx.doi.org/10.1155/2011/491039 |
| spellingShingle | Britta Huber Philip Dammann Christine Krüger Petra Kirsch Beatrix Bialek Roland A. Diaz-Bone Reinhard Hensel Production of Toxic Volatile Trimethylbismuth by the Intestinal Microbiota of Mice Journal of Toxicology |
| title | Production of Toxic Volatile Trimethylbismuth by the Intestinal Microbiota of Mice |
| title_full | Production of Toxic Volatile Trimethylbismuth by the Intestinal Microbiota of Mice |
| title_fullStr | Production of Toxic Volatile Trimethylbismuth by the Intestinal Microbiota of Mice |
| title_full_unstemmed | Production of Toxic Volatile Trimethylbismuth by the Intestinal Microbiota of Mice |
| title_short | Production of Toxic Volatile Trimethylbismuth by the Intestinal Microbiota of Mice |
| title_sort | production of toxic volatile trimethylbismuth by the intestinal microbiota of mice |
| url | http://dx.doi.org/10.1155/2011/491039 |
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