Castleman disease misdiagnosed as immunoglobulin G4-related disease: a case report
Castleman disease (CD) and immunoglobulin G4-related disease (IgG4-RD) are rare systemic immune-mediated disorders that share overlapping clinical features, posing significant challenges in differential diagnosis. Here, we present a case of generalized lymphadenopathy initially misdiagnosed as IgG4-...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1532627/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832583721624010752 |
|---|---|
| author | Na Li LiFen Xu Xiaoxia Liu Pengjia Wu Jun Liu Jiashun Zeng |
| author_facet | Na Li LiFen Xu Xiaoxia Liu Pengjia Wu Jun Liu Jiashun Zeng |
| author_sort | Na Li |
| collection | DOAJ |
| description | Castleman disease (CD) and immunoglobulin G4-related disease (IgG4-RD) are rare systemic immune-mediated disorders that share overlapping clinical features, posing significant challenges in differential diagnosis. Here, we present a case of generalized lymphadenopathy initially misdiagnosed as IgG4-RD, which demonstrated a poor response to hormonal therapy. Subsequent pathological biopsy and immunohistochemical analysis ultimately confirmed the diagnosis of CD. This case underscores the limitations of relying solely on serum IgG4 levels as a diagnostic marker to distinguish CD from IgG4-RD. Comprehensive evaluation, including clinical presentation, organ involvement, serological and pathological findings, as well as therapeutic response, is essential to ensure accurate diagnosis and timely management. |
| format | Article |
| id | doaj-art-73d6feef18da48fdbc7653725343e950 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-73d6feef18da48fdbc7653725343e9502025-01-28T06:41:20ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011610.3389/fimmu.2025.15326271532627Castleman disease misdiagnosed as immunoglobulin G4-related disease: a case reportNa Li0LiFen Xu1Xiaoxia Liu2Pengjia Wu3Jun Liu4Jiashun Zeng5Department of Rheumatology and Immunology, The Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaPathology Department, The Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaDepartment of Rheumatology and Immunology, The Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaDepartment of Rheumatology and Immunology, The Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaDepartment of Rheumatology and Immunology, The Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaDepartment of Rheumatology and Immunology, The Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaCastleman disease (CD) and immunoglobulin G4-related disease (IgG4-RD) are rare systemic immune-mediated disorders that share overlapping clinical features, posing significant challenges in differential diagnosis. Here, we present a case of generalized lymphadenopathy initially misdiagnosed as IgG4-RD, which demonstrated a poor response to hormonal therapy. Subsequent pathological biopsy and immunohistochemical analysis ultimately confirmed the diagnosis of CD. This case underscores the limitations of relying solely on serum IgG4 levels as a diagnostic marker to distinguish CD from IgG4-RD. Comprehensive evaluation, including clinical presentation, organ involvement, serological and pathological findings, as well as therapeutic response, is essential to ensure accurate diagnosis and timely management.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1532627/fullCastleman diseaseIgG4-related diseaseimmune-mediated disorderslymphadenopathyaccurate diagnosis |
| spellingShingle | Na Li LiFen Xu Xiaoxia Liu Pengjia Wu Jun Liu Jiashun Zeng Castleman disease misdiagnosed as immunoglobulin G4-related disease: a case report Frontiers in Immunology Castleman disease IgG4-related disease immune-mediated disorders lymphadenopathy accurate diagnosis |
| title | Castleman disease misdiagnosed as immunoglobulin G4-related disease: a case report |
| title_full | Castleman disease misdiagnosed as immunoglobulin G4-related disease: a case report |
| title_fullStr | Castleman disease misdiagnosed as immunoglobulin G4-related disease: a case report |
| title_full_unstemmed | Castleman disease misdiagnosed as immunoglobulin G4-related disease: a case report |
| title_short | Castleman disease misdiagnosed as immunoglobulin G4-related disease: a case report |
| title_sort | castleman disease misdiagnosed as immunoglobulin g4 related disease a case report |
| topic | Castleman disease IgG4-related disease immune-mediated disorders lymphadenopathy accurate diagnosis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1532627/full |
| work_keys_str_mv | AT nali castlemandiseasemisdiagnosedasimmunoglobuling4relateddiseaseacasereport AT lifenxu castlemandiseasemisdiagnosedasimmunoglobuling4relateddiseaseacasereport AT xiaoxialiu castlemandiseasemisdiagnosedasimmunoglobuling4relateddiseaseacasereport AT pengjiawu castlemandiseasemisdiagnosedasimmunoglobuling4relateddiseaseacasereport AT junliu castlemandiseasemisdiagnosedasimmunoglobuling4relateddiseaseacasereport AT jiashunzeng castlemandiseasemisdiagnosedasimmunoglobuling4relateddiseaseacasereport |