Therapy with murinized tobevibart and elebsiran is efficacious in a liver-chimeric mouse model of HDV infection

Therapy with murinized tobevibart and elebsiran is efficacious in a liver-chimeric mouse model of HDV infection

Background & Aims: Chronic hepatitis delta virus (HDV) infection represents the most severe form of viral hepatitis. HDV is a satellite virus of hepatitis B virus (HBV) and depends on the hepatitis B surface antigen (HBsAg) for envelopment and viral entry. Tobevibart (VIR-3434) is an investi...

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Bibliographic Details
Main Authors:	Jiayi Zhou, Hannah Kaiser, Evelyn Rocha, Ashley N. Terrell, Davide Corti, Lisa A. Purcell, Florian A. Lempp, Andreas S. Puschnik
Format:	Article
Language:	English
Published:	Elsevier 2025-06-01
Series:	JHEP Reports
Subjects:	Hepatitis B virus (HBV) Hepatitis delta virus (HDV) chronic infection monoclonal antibody (mAb) neutralization small interfering RNA (siRNA)
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589555925000771
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