Local Bone Marrow Renin-Angiotensin System and Atherosclerosis
Local hematopoietic bone marrow (BM) renin-angiotensin system (RAS) affects the growth, production, proliferation differentiation, and function of hematopoietic cells. Angiotensin II (Ang II), the dominant effector peptide of the RAS, regulates cellular growth in a wide variety of tissues in pathobi...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.4061/2011/714515 |
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| author | Yavuz Beyazit Tugrul Purnak Gulay Sain Guven Ibrahim C. Haznedaroglu |
| author_facet | Yavuz Beyazit Tugrul Purnak Gulay Sain Guven Ibrahim C. Haznedaroglu |
| author_sort | Yavuz Beyazit |
| collection | DOAJ |
| description | Local hematopoietic bone marrow (BM) renin-angiotensin system (RAS) affects the growth, production, proliferation differentiation, and function of hematopoietic cells. Angiotensin II (Ang II), the dominant effector peptide of the RAS, regulates cellular growth in a wide variety of tissues in pathobiological states. RAS, especially Ang II and Ang II type 1 receptor (AT1R), has considerable proinflammatory and proatherogenic effects on the vessel wall, causing progression of atherosclerosis. Recent investigations, by analyzing several BM chimeric mice whose BM cells were positive or negative for AT1R, disclosed that AT1R in BM cells participates in the pathogenesis of atherosclerosis. Therefore, AT1R blocking not only in vascular cells but also in the BM could be an important therapeutic approach to prevent atherosclerosis. The aim of this paper is to review the function of local BM RAS in the pathogenesis of atherosclerosis. |
| format | Article |
| id | doaj-art-73b07594348d437c8184f5ce00a38607 |
| institution | Kabale University |
| issn | 2090-0597 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-73b07594348d437c8184f5ce00a386072025-02-03T01:31:33ZengWileyCardiology Research and Practice2090-05972011-01-01201110.4061/2011/714515714515Local Bone Marrow Renin-Angiotensin System and AtherosclerosisYavuz Beyazit0Tugrul Purnak1Gulay Sain Guven2Ibrahim C. Haznedaroglu3Department of Gastroenterology, Turkiye Yuksek Ihtisas Teaching and Research Hospital, 06100 Ankara, TurkeyDepartment of Gastroenterology, Ankara Numune Education and Research Hospital, 06100 Ankara, TurkeyDepartment of Internal Medicine, Faculty of Medicine, Hacettepe University, 06100 Ankara, TurkeyDepartment of Gastroenterology, Turkiye Yuksek Ihtisas Teaching and Research Hospital, 06100 Ankara, TurkeyLocal hematopoietic bone marrow (BM) renin-angiotensin system (RAS) affects the growth, production, proliferation differentiation, and function of hematopoietic cells. Angiotensin II (Ang II), the dominant effector peptide of the RAS, regulates cellular growth in a wide variety of tissues in pathobiological states. RAS, especially Ang II and Ang II type 1 receptor (AT1R), has considerable proinflammatory and proatherogenic effects on the vessel wall, causing progression of atherosclerosis. Recent investigations, by analyzing several BM chimeric mice whose BM cells were positive or negative for AT1R, disclosed that AT1R in BM cells participates in the pathogenesis of atherosclerosis. Therefore, AT1R blocking not only in vascular cells but also in the BM could be an important therapeutic approach to prevent atherosclerosis. The aim of this paper is to review the function of local BM RAS in the pathogenesis of atherosclerosis.http://dx.doi.org/10.4061/2011/714515 |
| spellingShingle | Yavuz Beyazit Tugrul Purnak Gulay Sain Guven Ibrahim C. Haznedaroglu Local Bone Marrow Renin-Angiotensin System and Atherosclerosis Cardiology Research and Practice |
| title | Local Bone Marrow Renin-Angiotensin System and Atherosclerosis |
| title_full | Local Bone Marrow Renin-Angiotensin System and Atherosclerosis |
| title_fullStr | Local Bone Marrow Renin-Angiotensin System and Atherosclerosis |
| title_full_unstemmed | Local Bone Marrow Renin-Angiotensin System and Atherosclerosis |
| title_short | Local Bone Marrow Renin-Angiotensin System and Atherosclerosis |
| title_sort | local bone marrow renin angiotensin system and atherosclerosis |
| url | http://dx.doi.org/10.4061/2011/714515 |
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