BRAF V600E-Negative Hairy Cell Leukaemia
Since the initial report of the BRAF V600E mutation in hairy cell leukemia, numerous investigators have demonstrated the presence of this activating mutation in nearly all cases of this disease. A case of hairy cell leukemia is documented with a classical clinical, morphological, immunophenotypic, a...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2013/513049 |
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| _version_ | 1832565720737644544 |
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| author | Stephen E. Langabeer David O'Brien Anthony M. McElligott Michelle Lavin Paul V. Browne |
| author_facet | Stephen E. Langabeer David O'Brien Anthony M. McElligott Michelle Lavin Paul V. Browne |
| author_sort | Stephen E. Langabeer |
| collection | DOAJ |
| description | Since the initial report of the BRAF V600E mutation in hairy cell leukemia, numerous investigators have demonstrated the presence of this activating mutation in nearly all cases of this disease. A case of hairy cell leukemia is documented with a classical clinical, morphological, immunophenotypic, and cytochemical profile in which the BRAF V600E was not detected. The diagnostic and therapeutic implications are discussed. |
| format | Article |
| id | doaj-art-73972932fa9b404ba1fb73f7aad9d6cd |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-73972932fa9b404ba1fb73f7aad9d6cd2025-02-03T01:06:45ZengWileyCase Reports in Hematology2090-65602090-65792013-01-01201310.1155/2013/513049513049BRAF V600E-Negative Hairy Cell LeukaemiaStephen E. Langabeer0David O'Brien1Anthony M. McElligott2Michelle Lavin3Paul V. Browne4Cancer Molecular Diagnostics, Central Pathology Laboratory, St. James’s Hospital, Dublin 8, IrelandDepartment of Haematology, St. James’s Hospital, Dublin, IrelandDepartment of Haematology, Trinity College Dublin, Dublin, IrelandDepartment of Haematology, St. James’s Hospital, Dublin, IrelandDepartment of Haematology, St. James’s Hospital, Dublin, IrelandSince the initial report of the BRAF V600E mutation in hairy cell leukemia, numerous investigators have demonstrated the presence of this activating mutation in nearly all cases of this disease. A case of hairy cell leukemia is documented with a classical clinical, morphological, immunophenotypic, and cytochemical profile in which the BRAF V600E was not detected. The diagnostic and therapeutic implications are discussed.http://dx.doi.org/10.1155/2013/513049 |
| spellingShingle | Stephen E. Langabeer David O'Brien Anthony M. McElligott Michelle Lavin Paul V. Browne BRAF V600E-Negative Hairy Cell Leukaemia Case Reports in Hematology |
| title | BRAF V600E-Negative Hairy Cell Leukaemia |
| title_full | BRAF V600E-Negative Hairy Cell Leukaemia |
| title_fullStr | BRAF V600E-Negative Hairy Cell Leukaemia |
| title_full_unstemmed | BRAF V600E-Negative Hairy Cell Leukaemia |
| title_short | BRAF V600E-Negative Hairy Cell Leukaemia |
| title_sort | braf v600e negative hairy cell leukaemia |
| url | http://dx.doi.org/10.1155/2013/513049 |
| work_keys_str_mv | AT stephenelangabeer brafv600enegativehairycellleukaemia AT davidobrien brafv600enegativehairycellleukaemia AT anthonymmcelligott brafv600enegativehairycellleukaemia AT michellelavin brafv600enegativehairycellleukaemia AT paulvbrowne brafv600enegativehairycellleukaemia |