Implications of the Incidental Finding of a MYCN Amplified Adrenal Tumor: A Case Report and Update of a Pediatric Disease Diagnosed in Adults
MYCN is a well-known oncogene overexpressed in different human malignancies including neuroblastoma, rhabdomyosarcoma, medulloblastoma, astrocytoma, Wilms’ tumor, and small cell lung cancer. While neuroblastoma is one of the most common childhood malignancies, in adults it is extremely rare and its...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2013/393128 |
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| author | Anna Koumarianou Panagiota Oikonomopoulou Margarita Baka Dimitrios Vlachodimitropoulos Stylianos Argentos Theodoros Piperos Maria-Ioanna Christodoulou Kakoulis Theodoulou Theodoros Mariolis-Sapsakos |
| author_facet | Anna Koumarianou Panagiota Oikonomopoulou Margarita Baka Dimitrios Vlachodimitropoulos Stylianos Argentos Theodoros Piperos Maria-Ioanna Christodoulou Kakoulis Theodoulou Theodoros Mariolis-Sapsakos |
| author_sort | Anna Koumarianou |
| collection | DOAJ |
| description | MYCN is a well-known oncogene overexpressed in different human malignancies including neuroblastoma, rhabdomyosarcoma, medulloblastoma, astrocytoma, Wilms’ tumor, and small cell lung cancer. While neuroblastoma is one of the most common childhood malignancies, in adults it is extremely rare and its treatment is based on pediatric protocols that take into consideration stage and genotypic features, such as MYCN amplification. Although neuroblastoma therapy has evolved, identification of early stage patients who need chemotherapy continues to pose a therapeutic challenge. The emerging prognostic role of MYCN phenotype of this disease is currently under investigation as it may redefine MYCN amplified subgroups. We describe an unusual case of adult neuroblastoma with MYCN amplification diagnosed incidentally and discuss possible therapeutic dilemmas. |
| format | Article |
| id | doaj-art-738bdf584dba4ed18c80c2c16180c79f |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-738bdf584dba4ed18c80c2c16180c79f2025-02-03T06:48:37ZengWileyCase Reports in Oncological Medicine2090-67062090-67142013-01-01201310.1155/2013/393128393128Implications of the Incidental Finding of a MYCN Amplified Adrenal Tumor: A Case Report and Update of a Pediatric Disease Diagnosed in AdultsAnna Koumarianou0Panagiota Oikonomopoulou1Margarita Baka2Dimitrios Vlachodimitropoulos3Stylianos Argentos4Theodoros Piperos5Maria-Ioanna Christodoulou6Kakoulis Theodoulou7Theodoros Mariolis-Sapsakos8Fourth Department of Internal Medicine, Attikon University Hospital, Rimini 1, 12462 Haidari, Athens, GreeceDepartment of Medical Oncology, St Bartholomew’s Hospital, West Smithfield, London EC1A 7BE, UKDepartment of Pediatric Hematology-Oncology, “Pan. & Aglaia Kyriakou” Children's Hospital, Thivon & Livadias Street, 11527 Athens, GreeceLaboratory Forensic Medicine and Toxicology, Evgenidion Hospital University of Athens, 76th V. Sofias, 11528 Athens, GreeceRadiology Department, Attikon University Hospital, 1st Rimini Street, 12462 Athens, GreeceDepartment of Surgery, Evgenidion Hospital, 20th Papadiamantopoulou Street, 11528 Athens, GreeceDepartment of Biochemistry and Molecular Biology, University of Athens, Panepistimiopolis, 15701 Athens, GreeceDepartment of Surgery, Evgenidion Hospital, 20th Papadiamantopoulou Street, 11528 Athens, GreeceDepartment of Surgery, Evgenidion Hospital, 20th Papadiamantopoulou Street, 11528 Athens, GreeceMYCN is a well-known oncogene overexpressed in different human malignancies including neuroblastoma, rhabdomyosarcoma, medulloblastoma, astrocytoma, Wilms’ tumor, and small cell lung cancer. While neuroblastoma is one of the most common childhood malignancies, in adults it is extremely rare and its treatment is based on pediatric protocols that take into consideration stage and genotypic features, such as MYCN amplification. Although neuroblastoma therapy has evolved, identification of early stage patients who need chemotherapy continues to pose a therapeutic challenge. The emerging prognostic role of MYCN phenotype of this disease is currently under investigation as it may redefine MYCN amplified subgroups. We describe an unusual case of adult neuroblastoma with MYCN amplification diagnosed incidentally and discuss possible therapeutic dilemmas.http://dx.doi.org/10.1155/2013/393128 |
| spellingShingle | Anna Koumarianou Panagiota Oikonomopoulou Margarita Baka Dimitrios Vlachodimitropoulos Stylianos Argentos Theodoros Piperos Maria-Ioanna Christodoulou Kakoulis Theodoulou Theodoros Mariolis-Sapsakos Implications of the Incidental Finding of a MYCN Amplified Adrenal Tumor: A Case Report and Update of a Pediatric Disease Diagnosed in Adults Case Reports in Oncological Medicine |
| title | Implications of the Incidental Finding of a MYCN Amplified Adrenal Tumor: A Case Report and Update of a Pediatric Disease Diagnosed in Adults |
| title_full | Implications of the Incidental Finding of a MYCN Amplified Adrenal Tumor: A Case Report and Update of a Pediatric Disease Diagnosed in Adults |
| title_fullStr | Implications of the Incidental Finding of a MYCN Amplified Adrenal Tumor: A Case Report and Update of a Pediatric Disease Diagnosed in Adults |
| title_full_unstemmed | Implications of the Incidental Finding of a MYCN Amplified Adrenal Tumor: A Case Report and Update of a Pediatric Disease Diagnosed in Adults |
| title_short | Implications of the Incidental Finding of a MYCN Amplified Adrenal Tumor: A Case Report and Update of a Pediatric Disease Diagnosed in Adults |
| title_sort | implications of the incidental finding of a mycn amplified adrenal tumor a case report and update of a pediatric disease diagnosed in adults |
| url | http://dx.doi.org/10.1155/2013/393128 |
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