Lysophosphatidylcholine: A Novel Modulator of Trypanosoma cruzi Transmission
Lysophosphatidylcholine is a bioactive lipid that regulates a large number of cellular processes and is especially present during the deposition and infiltration of inflammatory cells and deposition of atheromatous plaque. Such molecule is also present in saliva and feces of the hematophagous organi...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Parasitology Research |
| Online Access: | http://dx.doi.org/10.1155/2012/625838 |
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| author | Mário A. C. Silva-Neto Alan B. Carneiro Livia Silva-Cardoso Georgia C. Atella |
| author_facet | Mário A. C. Silva-Neto Alan B. Carneiro Livia Silva-Cardoso Georgia C. Atella |
| author_sort | Mário A. C. Silva-Neto |
| collection | DOAJ |
| description | Lysophosphatidylcholine is a bioactive lipid that regulates a large number of cellular processes and is especially present during the deposition and infiltration of inflammatory cells and deposition of atheromatous plaque. Such molecule is also present in saliva and feces of the hematophagous organism Rhodnius prolixus, a triatominae bug vector of Chagas disease. We have recently demonstrated that LPC is a modulator of Trypanosoma cruzi transmission. It acts as a powerful chemoattractant for inflammatory cells at the site of the insect bite, which will provide a concentrated population of cells available for parasite infection. Also, LPC increases macrophage intracellular calcium concentrations that ultimately enhance parasite invasion. Finally, LPC inhibits NO production by macrophages stimulated by live T. cruzi, and thus interferes with the immune system of the vertebrate host. In the present paper, we discuss the main signaling mechanisms that are likely used by such molecule and their eventual use as targets to block parasite transmission and the pathogenesis of Chagas disease. |
| format | Article |
| id | doaj-art-738bd2bc80864505966aa1e880b4e716 |
| institution | Kabale University |
| issn | 2090-0023 2090-0031 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Parasitology Research |
| spelling | doaj-art-738bd2bc80864505966aa1e880b4e7162025-02-03T01:26:28ZengWileyJournal of Parasitology Research2090-00232090-00312012-01-01201210.1155/2012/625838625838Lysophosphatidylcholine: A Novel Modulator of Trypanosoma cruzi TransmissionMário A. C. Silva-Neto0Alan B. Carneiro1Livia Silva-Cardoso2Georgia C. Atella3Instituto de Bioquímica Médica at Universidade Federal do Rio de Janeiro (UFRJ), 21940-590 Rio de Janeiro, RJ, BrazilInstituto de Bioquímica Médica at Universidade Federal do Rio de Janeiro (UFRJ), 21940-590 Rio de Janeiro, RJ, BrazilInstituto de Bioquímica Médica at Universidade Federal do Rio de Janeiro (UFRJ), 21940-590 Rio de Janeiro, RJ, BrazilInstituto de Bioquímica Médica at Universidade Federal do Rio de Janeiro (UFRJ), 21940-590 Rio de Janeiro, RJ, BrazilLysophosphatidylcholine is a bioactive lipid that regulates a large number of cellular processes and is especially present during the deposition and infiltration of inflammatory cells and deposition of atheromatous plaque. Such molecule is also present in saliva and feces of the hematophagous organism Rhodnius prolixus, a triatominae bug vector of Chagas disease. We have recently demonstrated that LPC is a modulator of Trypanosoma cruzi transmission. It acts as a powerful chemoattractant for inflammatory cells at the site of the insect bite, which will provide a concentrated population of cells available for parasite infection. Also, LPC increases macrophage intracellular calcium concentrations that ultimately enhance parasite invasion. Finally, LPC inhibits NO production by macrophages stimulated by live T. cruzi, and thus interferes with the immune system of the vertebrate host. In the present paper, we discuss the main signaling mechanisms that are likely used by such molecule and their eventual use as targets to block parasite transmission and the pathogenesis of Chagas disease.http://dx.doi.org/10.1155/2012/625838 |
| spellingShingle | Mário A. C. Silva-Neto Alan B. Carneiro Livia Silva-Cardoso Georgia C. Atella Lysophosphatidylcholine: A Novel Modulator of Trypanosoma cruzi Transmission Journal of Parasitology Research |
| title | Lysophosphatidylcholine: A Novel Modulator of Trypanosoma cruzi Transmission |
| title_full | Lysophosphatidylcholine: A Novel Modulator of Trypanosoma cruzi Transmission |
| title_fullStr | Lysophosphatidylcholine: A Novel Modulator of Trypanosoma cruzi Transmission |
| title_full_unstemmed | Lysophosphatidylcholine: A Novel Modulator of Trypanosoma cruzi Transmission |
| title_short | Lysophosphatidylcholine: A Novel Modulator of Trypanosoma cruzi Transmission |
| title_sort | lysophosphatidylcholine a novel modulator of trypanosoma cruzi transmission |
| url | http://dx.doi.org/10.1155/2012/625838 |
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