The antioxidant, anti-inflammatory, and anti-apoptotic effects of sesamin against cisplatin-induced renal and testicular toxicity in rats

The antioxidant, anti-inflammatory, and anti-apoptotic effects of sesamin against cisplatin-induced renal and testicular toxicity in rats

Purpose The present study investigated the nephron-testicular protective effects of sesamin against cisplatin (CP)-induced acute renal and testicular injuries.Methods Thirty-two male Wistar rats were allocated to receive carboxymethylcellulose (0.5%, as sesamin vehicle), CP (a single i.p. 5 mg/kg do...

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Bibliographic Details
Main Authors: Ahmed E. Altyar, Ghadeer M. Albadrani, Sameh M. Farouk, Mariam K. Alamoudi, Amany A. Sayed, Zuhair M. Mohammedsaleh, Muath Q. Al-Ghadi, Rasha Mohammed Saleem, Hader I. Sakr, Mohamed M. Abdel-Daim
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Renal Failure
Subjects:
Cisplatin
cyclooxygenase
inflammation
oxidative stress
p53
sesamin
Online Access:https://www.tandfonline.com/doi/10.1080/0886022X.2024.2378212
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