Molecular landscape of salivary gland malignancies. What is already known?
Salivary gland carcinomas (SGCs) are highly heterogeneous histopathological entities that arise in either the major or minor salivary glands. Although uncommon, these tumours exhibit considerable aggressiveness, unpredictable progression, and significant mortality. The fifth edition of the World Hea...
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| Language: | English |
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Termedia Publishing House
2024-10-01
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| Series: | Contemporary Oncology |
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| Online Access: | https://www.termedia.pl/Molecular-landscape-of-salivary-gland-malignancies-What-is-already-known-,3,55007,1,1.html |
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| author | Julia Pikul Anna Rzepakowska |
| author_facet | Julia Pikul Anna Rzepakowska |
| author_sort | Julia Pikul |
| collection | DOAJ |
| description | Salivary gland carcinomas (SGCs) are highly heterogeneous histopathological entities that arise in either the major or minor salivary glands. Although uncommon, these tumours exhibit considerable aggressiveness, unpredictable progression, and significant mortality. The fifth edition of the World Health Organisation classification of head and neck tumours distinguishes between 24 salivary gland malignancies. This may lead to difficulties in terms of diagnostic accuracy and suitable therapeutic selection. Mucoepidermoid carcinoma occurs most frequently and is characterised by gradual disease progression. Although salivary duct carcinoma, myoepithelial carcinoma, and carcinoma ex pleomorphic adenoma are rarely detected, they contribute to poor patient outcomes. Currently, attempts have been made to establish molecular characterisation of SGCs to improve differential diagnosis and create targeted treatments. This study aimed to summarise current knowledge regarding genetic variations in the most common salivary gland malignancies. |
| format | Article |
| id | doaj-art-737ee8a087494e509e759c041ad9bbca |
| institution | Kabale University |
| issn | 1428-2526 1897-4309 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Contemporary Oncology |
| spelling | doaj-art-737ee8a087494e509e759c041ad9bbca2025-01-27T11:19:21ZengTermedia Publishing HouseContemporary Oncology1428-25261897-43092024-10-0128320121610.5114/wo.2024.14428855007Molecular landscape of salivary gland malignancies. What is already known?Julia PikulAnna RzepakowskaSalivary gland carcinomas (SGCs) are highly heterogeneous histopathological entities that arise in either the major or minor salivary glands. Although uncommon, these tumours exhibit considerable aggressiveness, unpredictable progression, and significant mortality. The fifth edition of the World Health Organisation classification of head and neck tumours distinguishes between 24 salivary gland malignancies. This may lead to difficulties in terms of diagnostic accuracy and suitable therapeutic selection. Mucoepidermoid carcinoma occurs most frequently and is characterised by gradual disease progression. Although salivary duct carcinoma, myoepithelial carcinoma, and carcinoma ex pleomorphic adenoma are rarely detected, they contribute to poor patient outcomes. Currently, attempts have been made to establish molecular characterisation of SGCs to improve differential diagnosis and create targeted treatments. This study aimed to summarise current knowledge regarding genetic variations in the most common salivary gland malignancies.https://www.termedia.pl/Molecular-landscape-of-salivary-gland-malignancies-What-is-already-known-,3,55007,1,1.htmlsalivary gland carcinoma molecular landscape genetic alterations ngs |
| spellingShingle | Julia Pikul Anna Rzepakowska Molecular landscape of salivary gland malignancies. What is already known? Contemporary Oncology salivary gland carcinoma molecular landscape genetic alterations ngs |
| title | Molecular landscape of salivary gland malignancies. What is already known? |
| title_full | Molecular landscape of salivary gland malignancies. What is already known? |
| title_fullStr | Molecular landscape of salivary gland malignancies. What is already known? |
| title_full_unstemmed | Molecular landscape of salivary gland malignancies. What is already known? |
| title_short | Molecular landscape of salivary gland malignancies. What is already known? |
| title_sort | molecular landscape of salivary gland malignancies what is already known |
| topic | salivary gland carcinoma molecular landscape genetic alterations ngs |
| url | https://www.termedia.pl/Molecular-landscape-of-salivary-gland-malignancies-What-is-already-known-,3,55007,1,1.html |
| work_keys_str_mv | AT juliapikul molecularlandscapeofsalivaryglandmalignancieswhatisalreadyknown AT annarzepakowska molecularlandscapeofsalivaryglandmalignancieswhatisalreadyknown |