Elastic Modulus of Osteoporotic Mouse Femur Based on Femoral Head Compression Test
A biomechanical test is a good evaluation method that describes the structural, functional, and pathological differences in the bones, such as osteoporosis and fracture. The tensile test, compression test, and bending test are generally performed to evaluate the elastic modulus of the bone using mic...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Applied Bionics and Biomechanics |
| Online Access: | http://dx.doi.org/10.1155/2017/7201769 |
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| author | Chang-soo Chon Hui-suk Yun Han Sung Kim Cheolwoong Ko |
| author_facet | Chang-soo Chon Hui-suk Yun Han Sung Kim Cheolwoong Ko |
| author_sort | Chang-soo Chon |
| collection | DOAJ |
| description | A biomechanical test is a good evaluation method that describes the structural, functional, and pathological differences in the bones, such as osteoporosis and fracture. The tensile test, compression test, and bending test are generally performed to evaluate the elastic modulus of the bone using mice. In particular, the femoral head compression test is mainly used for verifying the osteoporosis change of the femoral neck. This study conducted bone mineral density analysis using in vivo microcomputed tomography (micro-CT) to observe changes in osteoporosis over time. It proposed a method of identifying the elastic modulus of the femur in the normal group (CON group) and the osteoporotic group (OVX group) through finite element analysis based on the femoral head compression test and also conducted a comparative analysis of the results. Through the femoral head compression test, it was verified that the CON group’s ultimate and yield loads were significantly higher than those of the OVX group. It was considered that this result was caused by the fact that the bone mineral density change by osteoporosis occurred in the proximal end more often than in the femur diaphysis. However, the elastic modulus derived from the finite element analysis showed no significant difference between the two groups. |
| format | Article |
| id | doaj-art-7359c0be4a5149209bbb223b711b5364 |
| institution | Kabale University |
| issn | 1176-2322 1754-2103 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Applied Bionics and Biomechanics |
| spelling | doaj-art-7359c0be4a5149209bbb223b711b53642025-02-03T01:25:41ZengWileyApplied Bionics and Biomechanics1176-23221754-21032017-01-01201710.1155/2017/72017697201769Elastic Modulus of Osteoporotic Mouse Femur Based on Femoral Head Compression TestChang-soo Chon0Hui-suk Yun1Han Sung Kim2Cheolwoong Ko3Department of Biomedical Engineering, Yonsei University, 1 Yeonsedae-gil, Heungeop-myeon, Wonju-si, Gangwon-do 26493, Republic of KoreaPower & Ceramic Division, Korea Institute of Materials Science (KIMS), 797 Changwon-daero, Seongsan-gu, Changwon-si, Gyeongsangnam-do 51508, Republic of KoreaDepartment of Biomedical Engineering, Yonsei University, 1 Yeonsedae-gil, Heungeop-myeon, Wonju-si, Gangwon-do 26493, Republic of KoreaBiomedical System & Technology Group, Korea Institute of Industrial Technology (KITECH), 89 Yangdaegiro-gil, Ipjang-myeon, Seobuk-gu, Cheonan-si, Chungcheongnam-do 31056, Republic of KoreaA biomechanical test is a good evaluation method that describes the structural, functional, and pathological differences in the bones, such as osteoporosis and fracture. The tensile test, compression test, and bending test are generally performed to evaluate the elastic modulus of the bone using mice. In particular, the femoral head compression test is mainly used for verifying the osteoporosis change of the femoral neck. This study conducted bone mineral density analysis using in vivo microcomputed tomography (micro-CT) to observe changes in osteoporosis over time. It proposed a method of identifying the elastic modulus of the femur in the normal group (CON group) and the osteoporotic group (OVX group) through finite element analysis based on the femoral head compression test and also conducted a comparative analysis of the results. Through the femoral head compression test, it was verified that the CON group’s ultimate and yield loads were significantly higher than those of the OVX group. It was considered that this result was caused by the fact that the bone mineral density change by osteoporosis occurred in the proximal end more often than in the femur diaphysis. However, the elastic modulus derived from the finite element analysis showed no significant difference between the two groups.http://dx.doi.org/10.1155/2017/7201769 |
| spellingShingle | Chang-soo Chon Hui-suk Yun Han Sung Kim Cheolwoong Ko Elastic Modulus of Osteoporotic Mouse Femur Based on Femoral Head Compression Test Applied Bionics and Biomechanics |
| title | Elastic Modulus of Osteoporotic Mouse Femur Based on Femoral Head Compression Test |
| title_full | Elastic Modulus of Osteoporotic Mouse Femur Based on Femoral Head Compression Test |
| title_fullStr | Elastic Modulus of Osteoporotic Mouse Femur Based on Femoral Head Compression Test |
| title_full_unstemmed | Elastic Modulus of Osteoporotic Mouse Femur Based on Femoral Head Compression Test |
| title_short | Elastic Modulus of Osteoporotic Mouse Femur Based on Femoral Head Compression Test |
| title_sort | elastic modulus of osteoporotic mouse femur based on femoral head compression test |
| url | http://dx.doi.org/10.1155/2017/7201769 |
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