Evaluation of Sericin/Polyvinyl Alcohol Mixtures for Developing Porous and Stable Structures
Fibrous by-products, including defective or double cocoons, are obtained during silk processing. These cocoons primarily contain fibroin and sericin (SS) proteins along with minor amounts of wax and mineral salts. In conventional textile processes, SS is removed in the production of smooth, lustrous...
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2025-01-01
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| author | Maria C. Arango Leander Vásquez Vásquez Akemy Carolina Homma Parra Santiago Rueda-Mira Natalia Jaramillo-Quiceno Josep Pasqual Cerisuelo Amparo Cháfer Catalina Álvarez-López |
| author_facet | Maria C. Arango Leander Vásquez Vásquez Akemy Carolina Homma Parra Santiago Rueda-Mira Natalia Jaramillo-Quiceno Josep Pasqual Cerisuelo Amparo Cháfer Catalina Álvarez-López |
| author_sort | Maria C. Arango |
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| description | Fibrous by-products, including defective or double cocoons, are obtained during silk processing. These cocoons primarily contain fibroin and sericin (SS) proteins along with minor amounts of wax and mineral salts. In conventional textile processes, SS is removed in the production of smooth, lustrous silk threads, and is typically discarded. However, SS has garnered attention for its antioxidant, antibacterial, biocompatible, and anticancer properties as well as its excellent moisture absorption, making it a promising polymer for biomedical applications. Owing to its functional groups (carboxyl, amino, and hydroxyl), SS can blend and crosslink with other polymers, thereby improving the mechanical properties of sericin-based materials. This study explored the effects of different SS/polyvinyl alcohol (PVA) ratios on porous scaffolds fabricated via freeze-drying, focusing on the mechanical stability, water absorption, and protein release in phosphate-buffered saline (PBS). The scaffold morphology revealed reduced porosity with higher SS content, while increased PVA content led to material folding and layering. A greater PVA content enhanced water absorption, mechanical properties, and thermal stability, although SS release decreased. These results demonstrate that scaffold properties can be tailored by optimizing the SS/PVA ratio to suit specific biomedical applications. |
| format | Article |
| id | doaj-art-7351edbb00264fdc91176e08bc190b70 |
| institution | Kabale University |
| issn | 2313-7673 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomimetics |
| spelling | doaj-art-7351edbb00264fdc91176e08bc190b702025-01-24T13:24:39ZengMDPI AGBiomimetics2313-76732025-01-011012710.3390/biomimetics10010027Evaluation of Sericin/Polyvinyl Alcohol Mixtures for Developing Porous and Stable StructuresMaria C. Arango0Leander Vásquez Vásquez1Akemy Carolina Homma Parra2Santiago Rueda-Mira3Natalia Jaramillo-Quiceno4Josep Pasqual Cerisuelo5Amparo Cháfer6Catalina Álvarez-López7Agroindustrial Research Group, Department of Chemical Engineering, Universidad Pontificia Bolivariana, Cq. 1 #70-01, Medellín 050031, ColombiaAgroindustrial Research Group, Department of Chemical Engineering, Universidad Pontificia Bolivariana, Cq. 1 #70-01, Medellín 050031, ColombiaAgroindustrial Research Group, Department of Chemical Engineering, Universidad Pontificia Bolivariana, Cq. 1 #70-01, Medellín 050031, ColombiaAgroindustrial Research Group, Department of Chemical Engineering, Universidad Pontificia Bolivariana, Cq. 1 #70-01, Medellín 050031, ColombiaAgroindustrial Research Group, Department of Chemical Engineering, Universidad Pontificia Bolivariana, Cq. 1 #70-01, Medellín 050031, ColombiaMaterials Technology and Sustainability (MATS), Department of Chemical Engineering, Universitat de València, Av. de la Universitat s/n, 46100 Burjassot, SpainMaterials Technology and Sustainability (MATS), Department of Chemical Engineering, Universitat de València, Av. de la Universitat s/n, 46100 Burjassot, SpainAgroindustrial Research Group, Department of Chemical Engineering, Universidad Pontificia Bolivariana, Cq. 1 #70-01, Medellín 050031, ColombiaFibrous by-products, including defective or double cocoons, are obtained during silk processing. These cocoons primarily contain fibroin and sericin (SS) proteins along with minor amounts of wax and mineral salts. In conventional textile processes, SS is removed in the production of smooth, lustrous silk threads, and is typically discarded. However, SS has garnered attention for its antioxidant, antibacterial, biocompatible, and anticancer properties as well as its excellent moisture absorption, making it a promising polymer for biomedical applications. Owing to its functional groups (carboxyl, amino, and hydroxyl), SS can blend and crosslink with other polymers, thereby improving the mechanical properties of sericin-based materials. This study explored the effects of different SS/polyvinyl alcohol (PVA) ratios on porous scaffolds fabricated via freeze-drying, focusing on the mechanical stability, water absorption, and protein release in phosphate-buffered saline (PBS). The scaffold morphology revealed reduced porosity with higher SS content, while increased PVA content led to material folding and layering. A greater PVA content enhanced water absorption, mechanical properties, and thermal stability, although SS release decreased. These results demonstrate that scaffold properties can be tailored by optimizing the SS/PVA ratio to suit specific biomedical applications.https://www.mdpi.com/2313-7673/10/1/27silk sericinpolyvinyl alcoholscaffoldslyophilizationmixture |
| spellingShingle | Maria C. Arango Leander Vásquez Vásquez Akemy Carolina Homma Parra Santiago Rueda-Mira Natalia Jaramillo-Quiceno Josep Pasqual Cerisuelo Amparo Cháfer Catalina Álvarez-López Evaluation of Sericin/Polyvinyl Alcohol Mixtures for Developing Porous and Stable Structures Biomimetics silk sericin polyvinyl alcohol scaffolds lyophilization mixture |
| title | Evaluation of Sericin/Polyvinyl Alcohol Mixtures for Developing Porous and Stable Structures |
| title_full | Evaluation of Sericin/Polyvinyl Alcohol Mixtures for Developing Porous and Stable Structures |
| title_fullStr | Evaluation of Sericin/Polyvinyl Alcohol Mixtures for Developing Porous and Stable Structures |
| title_full_unstemmed | Evaluation of Sericin/Polyvinyl Alcohol Mixtures for Developing Porous and Stable Structures |
| title_short | Evaluation of Sericin/Polyvinyl Alcohol Mixtures for Developing Porous and Stable Structures |
| title_sort | evaluation of sericin polyvinyl alcohol mixtures for developing porous and stable structures |
| topic | silk sericin polyvinyl alcohol scaffolds lyophilization mixture |
| url | https://www.mdpi.com/2313-7673/10/1/27 |
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