An Immunomodulatory Device Improves Insulin Resistance in Obese Porcine Model of Metabolic Syndrome
Obesity is associated with tissue inflammation which is a crucial etiology of insulin resistance. This inflammation centers around circulating monocytes which form proinflammatory adipose tissue macrophages (ATM). Specific approaches targeting monocytes/ATM may improve insulin resistance without the...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/3486727 |
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| author | Angela J. Westover Kimberly A. Johnston Deborah A. Buffington H. David Humes |
| author_facet | Angela J. Westover Kimberly A. Johnston Deborah A. Buffington H. David Humes |
| author_sort | Angela J. Westover |
| collection | DOAJ |
| description | Obesity is associated with tissue inflammation which is a crucial etiology of insulin resistance. This inflammation centers around circulating monocytes which form proinflammatory adipose tissue macrophages (ATM). Specific approaches targeting monocytes/ATM may improve insulin resistance without the adverse side effects of generalized immunosuppression. In this regard, a biomimetic membrane leukocyte processing device, called the selective cytopheretic device (SCD), was evaluated in an Ossabaw miniature swine model of insulin resistance with metabolic syndrome. Treatment with the SCD in this porcine model demonstrated a decline in circulating neutrophil activation parameters and monocyte counts. These changes were associated with improvements in insulin resistance as determined with intravenous glucose tolerance testing. These improvements were also reflected in lowering of homeostatic model assessment- (HOMA-) insulin resistant (IR) scores for up to 2 weeks after SCD therapy. These results allow for the planning of first-in-man studies in obese type 2 diabetic patients. |
| format | Article |
| id | doaj-art-734ef56d5ae24833b04f31f1a22ef862 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-734ef56d5ae24833b04f31f1a22ef8622025-02-03T01:07:42ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/34867273486727An Immunomodulatory Device Improves Insulin Resistance in Obese Porcine Model of Metabolic SyndromeAngela J. Westover0Kimberly A. Johnston1Deborah A. Buffington2H. David Humes3Innovative BioTherapies, Inc., 650 Avis Drive, Suite 300, Ann Arbor, MI 48108, USAInnovative BioTherapies, Inc., 650 Avis Drive, Suite 300, Ann Arbor, MI 48108, USAInnovative BioTherapies, Inc., 650 Avis Drive, Suite 300, Ann Arbor, MI 48108, USAInnovative BioTherapies, Inc., 650 Avis Drive, Suite 300, Ann Arbor, MI 48108, USAObesity is associated with tissue inflammation which is a crucial etiology of insulin resistance. This inflammation centers around circulating monocytes which form proinflammatory adipose tissue macrophages (ATM). Specific approaches targeting monocytes/ATM may improve insulin resistance without the adverse side effects of generalized immunosuppression. In this regard, a biomimetic membrane leukocyte processing device, called the selective cytopheretic device (SCD), was evaluated in an Ossabaw miniature swine model of insulin resistance with metabolic syndrome. Treatment with the SCD in this porcine model demonstrated a decline in circulating neutrophil activation parameters and monocyte counts. These changes were associated with improvements in insulin resistance as determined with intravenous glucose tolerance testing. These improvements were also reflected in lowering of homeostatic model assessment- (HOMA-) insulin resistant (IR) scores for up to 2 weeks after SCD therapy. These results allow for the planning of first-in-man studies in obese type 2 diabetic patients.http://dx.doi.org/10.1155/2016/3486727 |
| spellingShingle | Angela J. Westover Kimberly A. Johnston Deborah A. Buffington H. David Humes An Immunomodulatory Device Improves Insulin Resistance in Obese Porcine Model of Metabolic Syndrome Journal of Diabetes Research |
| title | An Immunomodulatory Device Improves Insulin Resistance in Obese Porcine Model of Metabolic Syndrome |
| title_full | An Immunomodulatory Device Improves Insulin Resistance in Obese Porcine Model of Metabolic Syndrome |
| title_fullStr | An Immunomodulatory Device Improves Insulin Resistance in Obese Porcine Model of Metabolic Syndrome |
| title_full_unstemmed | An Immunomodulatory Device Improves Insulin Resistance in Obese Porcine Model of Metabolic Syndrome |
| title_short | An Immunomodulatory Device Improves Insulin Resistance in Obese Porcine Model of Metabolic Syndrome |
| title_sort | immunomodulatory device improves insulin resistance in obese porcine model of metabolic syndrome |
| url | http://dx.doi.org/10.1155/2016/3486727 |
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