AGGF1-primed endothelial progenitor cells alleviate ischaemia-reperfusion injury in diabetic hearts

AGGF1-primed endothelial progenitor cells alleviate ischaemia-reperfusion injury in diabetic hearts

Abstract A number of cardioprotective pharmacological agents are not effective in diabetic hearts. The role of AGGF1-EPCs therapy in diabetic ischaemia-reperfusion(I/R) injury and the underlying mechanism by which AGGF1 regulates EPCs under hyperglycemia (HG) + hypoxia/reoxygenation (H/R) stress are...

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Bibliographic Details
Main Authors: Xia Li, Suwan Mu, Shuting Huang, Congcong Dai, Yumei Li, Jianqiao Li, Liang Zhong, Miaoling Wei, Liuqing Wei, Yong Li
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
AGGF1
Endothelial progenitor cells
Reactive oxygen species
Ischaemia-reperfusion injury
Online Access:https://doi.org/10.1038/s41598-025-06190-8
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https://doi.org/10.1038/s41598-025-06190-8

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