Stimulation of neutrophil functions by C5adesArg: an in vitro model of haemodialysis
Cuprophane membranes during haemodialysis significantly increase the plasma levels of C5adesArg (maximal 55 μg C5aadesArg/1 blood after 30 min) whereas Hemophane or Polysulphonemembranes induce only low plasma levels of C5adesArg. C5adesArg generated in vitro by yeast incubation of autologous plasma...
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| Format: | Article |
| Language: | English |
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Wiley
1992-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935192000127 |
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| author | I. Eckle G. Kolb E. Martinez Martin K. Havemann |
| author_facet | I. Eckle G. Kolb E. Martinez Martin K. Havemann |
| author_sort | I. Eckle |
| collection | DOAJ |
| description | Cuprophane membranes during haemodialysis significantly increase the plasma levels of C5adesArg (maximal 55 μg C5aadesArg/1 blood after 30 min) whereas Hemophane or Polysulphonemembranes induce only low plasma levels of C5adesArg. C5adesArg generated in vitro by yeast incubation of autologous plasma stimulates PMN chemotaxis and oxidative metabolism but has no effect on enzyme release. Preincubation of whole blood with C5adesArg causes aggregation and changed oxidative burst activity of the isolated PMN. These changes are similar to those found in cells from patients after haemodialysis with cuprophane membranes. So the elevated plasma levels of C5adesArg after haemodialysis explain some of the changes in PMN functions, but additional mechanisms have to be assumed. |
| format | Article |
| id | doaj-art-7348c85e4cd5483b9b857590a8acde45 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1992-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-7348c85e4cd5483b9b857590a8acde452025-02-03T05:58:37ZengWileyMediators of Inflammation0962-93511466-18611992-01-0111616610.1155/S0962935192000127Stimulation of neutrophil functions by C5adesArg: an in vitro model of haemodialysisI. Eckle0G. Kolb1E. Martinez Martin2K. Havemann3Centre of Internal Medicine, Philipps-University, Baldinger Strasse, Marburg D-355, GermanyCentre of Internal Medicine, Philipps-University, Baldinger Strasse, Marburg D-355, GermanyCentre of Internal Medicine, Philipps-University, Baldinger Strasse, Marburg D-355, GermanyCentre of Internal Medicine, Philipps-University, Baldinger Strasse, Marburg D-355, GermanyCuprophane membranes during haemodialysis significantly increase the plasma levels of C5adesArg (maximal 55 μg C5aadesArg/1 blood after 30 min) whereas Hemophane or Polysulphonemembranes induce only low plasma levels of C5adesArg. C5adesArg generated in vitro by yeast incubation of autologous plasma stimulates PMN chemotaxis and oxidative metabolism but has no effect on enzyme release. Preincubation of whole blood with C5adesArg causes aggregation and changed oxidative burst activity of the isolated PMN. These changes are similar to those found in cells from patients after haemodialysis with cuprophane membranes. So the elevated plasma levels of C5adesArg after haemodialysis explain some of the changes in PMN functions, but additional mechanisms have to be assumed.http://dx.doi.org/10.1155/S0962935192000127 |
| spellingShingle | I. Eckle G. Kolb E. Martinez Martin K. Havemann Stimulation of neutrophil functions by C5adesArg: an in vitro model of haemodialysis Mediators of Inflammation |
| title | Stimulation of neutrophil functions by C5adesArg: an in vitro model of haemodialysis |
| title_full | Stimulation of neutrophil functions by C5adesArg: an in vitro model of haemodialysis |
| title_fullStr | Stimulation of neutrophil functions by C5adesArg: an in vitro model of haemodialysis |
| title_full_unstemmed | Stimulation of neutrophil functions by C5adesArg: an in vitro model of haemodialysis |
| title_short | Stimulation of neutrophil functions by C5adesArg: an in vitro model of haemodialysis |
| title_sort | stimulation of neutrophil functions by c5adesarg an in vitro model of haemodialysis |
| url | http://dx.doi.org/10.1155/S0962935192000127 |
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