Variational graph autoencoder for reconstructed transcriptomic data associated with NLRP3 mediated pyroptosis in periodontitis

Variational graph autoencoder for reconstructed transcriptomic data associated with NLRP3 mediated pyroptosis in periodontitis

Abstract The NLRP3 inflammasome, regulated by TLR4, plays a pivotal role in periodontitis by mediating inflammatory cytokine release and bone loss induced by Porphyromonas gingivalis. Periodontal disease creates a hypoxic environment, favoring anaerobic bacteria survival and exacerbating inflammatio...

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Bibliographic Details
Main Authors: Pradeep K. Yadalam, Prabhu Manickam Natarajan, Carlos M. Ardila
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Periodontitis
Variational autoencoders
Inflammasome
K means clustering
Online Access:https://doi.org/10.1038/s41598-025-86455-4
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