Podocyte Autophagy: A Potential Therapeutic Target to Prevent the Progression of Diabetic Nephropathy
Diabetic nephropathy (DN), a leading cause of end-stage renal disease (ESRD), becomes a worldwide problem. Ultrastructural changes of the glomerular filtration barrier, especially the pathological changes of podocytes, lead to proteinuria in patients with diabetes. Podocytes are major components of...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2017/3560238 |
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| _version_ | 1832548400565846016 |
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| author | Na Liu Liuqing Xu Yingfeng Shi Shougang Zhuang |
| author_facet | Na Liu Liuqing Xu Yingfeng Shi Shougang Zhuang |
| author_sort | Na Liu |
| collection | DOAJ |
| description | Diabetic nephropathy (DN), a leading cause of end-stage renal disease (ESRD), becomes a worldwide problem. Ultrastructural changes of the glomerular filtration barrier, especially the pathological changes of podocytes, lead to proteinuria in patients with diabetes. Podocytes are major components of glomerular filtration barrier, lining outside of the glomerular basement membrane (GBM) to maintain the permeability of the GBM. Autophagy is a high conserved cellular process in lysosomes including impaired protein, cell organelles, and other contents in the cytoplasm. Recent studies suggest that activation of autophagy in podocytes may be a potential therapy to prevent the progression of DN. Here, we review the mechanisms of autophagy in podocytes and discuss the current studies about alleviating proteinuria via activating podocyte autophagy. |
| format | Article |
| id | doaj-art-7332446a6da145de86d46e22c86650a8 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-7332446a6da145de86d46e22c86650a82025-02-03T06:14:06ZengWileyJournal of Diabetes Research2314-67452314-67532017-01-01201710.1155/2017/35602383560238Podocyte Autophagy: A Potential Therapeutic Target to Prevent the Progression of Diabetic NephropathyNa Liu0Liuqing Xu1Yingfeng Shi2Shougang Zhuang3Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, ChinaDiabetic nephropathy (DN), a leading cause of end-stage renal disease (ESRD), becomes a worldwide problem. Ultrastructural changes of the glomerular filtration barrier, especially the pathological changes of podocytes, lead to proteinuria in patients with diabetes. Podocytes are major components of glomerular filtration barrier, lining outside of the glomerular basement membrane (GBM) to maintain the permeability of the GBM. Autophagy is a high conserved cellular process in lysosomes including impaired protein, cell organelles, and other contents in the cytoplasm. Recent studies suggest that activation of autophagy in podocytes may be a potential therapy to prevent the progression of DN. Here, we review the mechanisms of autophagy in podocytes and discuss the current studies about alleviating proteinuria via activating podocyte autophagy.http://dx.doi.org/10.1155/2017/3560238 |
| spellingShingle | Na Liu Liuqing Xu Yingfeng Shi Shougang Zhuang Podocyte Autophagy: A Potential Therapeutic Target to Prevent the Progression of Diabetic Nephropathy Journal of Diabetes Research |
| title | Podocyte Autophagy: A Potential Therapeutic Target to Prevent the Progression of Diabetic Nephropathy |
| title_full | Podocyte Autophagy: A Potential Therapeutic Target to Prevent the Progression of Diabetic Nephropathy |
| title_fullStr | Podocyte Autophagy: A Potential Therapeutic Target to Prevent the Progression of Diabetic Nephropathy |
| title_full_unstemmed | Podocyte Autophagy: A Potential Therapeutic Target to Prevent the Progression of Diabetic Nephropathy |
| title_short | Podocyte Autophagy: A Potential Therapeutic Target to Prevent the Progression of Diabetic Nephropathy |
| title_sort | podocyte autophagy a potential therapeutic target to prevent the progression of diabetic nephropathy |
| url | http://dx.doi.org/10.1155/2017/3560238 |
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