Assessing the effect of foodborne endocrine disruptors exposure on methionine synthase activity in neuro-2a neuroblastoma cell lines
In the present study, in vitro neuronal cell cultures were exposed to the two most common varieties of EDCs reported in food, phthalates and bisphenol A (BPA). Specifically, Bis (2-ethylhexyl) phthalate (DEHP), Mono-butyl-phthalate (MBP), Di-n-octylphthalate (OP), and Bisphenol A (BPA) were exposed...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | All Life |
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| Online Access: | http://dx.doi.org/10.1080/26895293.2024.2407213 |
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| author | Gabriela García-Cerón Alba Fernanda Solano-González Iván Hazael Bello-Cortés Ileana Andrea Bonilla-Brunner Daniela Araiza-Olivera Manuel Gutiérrez-Aguilar Yazmin Ramiro-Cortés Marcos Francisco Rosetti Roeb García-Arrazola |
| author_facet | Gabriela García-Cerón Alba Fernanda Solano-González Iván Hazael Bello-Cortés Ileana Andrea Bonilla-Brunner Daniela Araiza-Olivera Manuel Gutiérrez-Aguilar Yazmin Ramiro-Cortés Marcos Francisco Rosetti Roeb García-Arrazola |
| author_sort | Gabriela García-Cerón |
| collection | DOAJ |
| description | In the present study, in vitro neuronal cell cultures were exposed to the two most common varieties of EDCs reported in food, phthalates and bisphenol A (BPA). Specifically, Bis (2-ethylhexyl) phthalate (DEHP), Mono-butyl-phthalate (MBP), Di-n-octylphthalate (OP), and Bisphenol A (BPA) were exposed in Neuro-2a neuroblastoma cell line. The enzymatic activity of methionine synthase (MS) was reduced by up to 3-fold in comparison to cultures that were not exposed to EDCs. MS is the key enzyme in the metabolic pathway that has been proposed elsewhere to be related to redox/methylation related disorders. |
| format | Article |
| id | doaj-art-7330a954408f48edbaa391b4f068b096 |
| institution | Kabale University |
| issn | 2689-5307 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | All Life |
| spelling | doaj-art-7330a954408f48edbaa391b4f068b0962025-01-20T14:38:00ZengTaylor & Francis GroupAll Life2689-53072024-12-01170110.1080/26895293.2024.24072132407213Assessing the effect of foodborne endocrine disruptors exposure on methionine synthase activity in neuro-2a neuroblastoma cell linesGabriela García-Cerón0Alba Fernanda Solano-González1Iván Hazael Bello-Cortés2Ileana Andrea Bonilla-Brunner3Daniela Araiza-Olivera4Manuel Gutiérrez-Aguilar5Yazmin Ramiro-Cortés6Marcos Francisco Rosetti7Roeb García-Arrazola8Universidad Nacional Autónoma de México (UNAM)Universidad Nacional Autónoma de México (UNAM)Universidad Nacional Autónoma de México (UNAM)R&D DepartmentFox Chase Cancer Center, Philadelphia, PA, USAUNAMUniversidad Nacional Autónoma de México (UNAM)Universidad Nacional Autónoma de México (UNAM)Universidad Nacional Autónoma de México (UNAM)In the present study, in vitro neuronal cell cultures were exposed to the two most common varieties of EDCs reported in food, phthalates and bisphenol A (BPA). Specifically, Bis (2-ethylhexyl) phthalate (DEHP), Mono-butyl-phthalate (MBP), Di-n-octylphthalate (OP), and Bisphenol A (BPA) were exposed in Neuro-2a neuroblastoma cell line. The enzymatic activity of methionine synthase (MS) was reduced by up to 3-fold in comparison to cultures that were not exposed to EDCs. MS is the key enzyme in the metabolic pathway that has been proposed elsewhere to be related to redox/methylation related disorders.http://dx.doi.org/10.1080/26895293.2024.2407213endocrine disrupting compounds (edcs)phthalatesbisphenol a (bpa)methionine synthase activityin vitro model |
| spellingShingle | Gabriela García-Cerón Alba Fernanda Solano-González Iván Hazael Bello-Cortés Ileana Andrea Bonilla-Brunner Daniela Araiza-Olivera Manuel Gutiérrez-Aguilar Yazmin Ramiro-Cortés Marcos Francisco Rosetti Roeb García-Arrazola Assessing the effect of foodborne endocrine disruptors exposure on methionine synthase activity in neuro-2a neuroblastoma cell lines All Life endocrine disrupting compounds (edcs) phthalates bisphenol a (bpa) methionine synthase activity in vitro model |
| title | Assessing the effect of foodborne endocrine disruptors exposure on methionine synthase activity in neuro-2a neuroblastoma cell lines |
| title_full | Assessing the effect of foodborne endocrine disruptors exposure on methionine synthase activity in neuro-2a neuroblastoma cell lines |
| title_fullStr | Assessing the effect of foodborne endocrine disruptors exposure on methionine synthase activity in neuro-2a neuroblastoma cell lines |
| title_full_unstemmed | Assessing the effect of foodborne endocrine disruptors exposure on methionine synthase activity in neuro-2a neuroblastoma cell lines |
| title_short | Assessing the effect of foodborne endocrine disruptors exposure on methionine synthase activity in neuro-2a neuroblastoma cell lines |
| title_sort | assessing the effect of foodborne endocrine disruptors exposure on methionine synthase activity in neuro 2a neuroblastoma cell lines |
| topic | endocrine disrupting compounds (edcs) phthalates bisphenol a (bpa) methionine synthase activity in vitro model |
| url | http://dx.doi.org/10.1080/26895293.2024.2407213 |
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