Ibuprofen reduces inflammation, necroptosis and protects photoreceptors from light-induced retinal degeneration

Ibuprofen reduces inflammation, necroptosis and protects photoreceptors from light-induced retinal degeneration

Abstract Background The retinal degenerative diseases retinitis pigmentosa (RP) and atrophic age- related macular degeneration (AMD) are characterized by vision loss from photoreceptor (PR) degeneration. Unfortunately, current treatments for these diseases are limited at best. Genetic and other prec...

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Main Authors: Ping-Wu Zhang, Zi-He Wan, Weifeng Li, Abhishek Vats, Kunal Mehta, Laura Fan, Lingli Zhou, Sean Li, Gloria Li, Casey J. Keuthan, Cynthia Berlinicke, Cheng Qian, Noriko Esumi, Elia J Duh, Donald J. Zack
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Neuroinflammation
Subjects:
Ibuprofen
Retina
Photoreceptor
Retinal degeneration
Retinitis pigmentosa
Macular degeneration
Online Access:https://doi.org/10.1186/s12974-024-03329-8
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