Epidemiology of sickle cell disease in tribal population of Southern Rajasthan, India
Abstract Background & objectives Sickle Cell Disease (SCD), a genetic condition, carries significant public health implications due to its impact on mortality, morbidity and quality of life. SCD is prevalent among tribal communities. The objective of this study was to conduct a screening of the...
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Nature Portfolio
2025-01-01
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| author | Anil Purohit Ramesh K. Huda Suman S. Mohanty Bontha V. Babu |
| author_facet | Anil Purohit Ramesh K. Huda Suman S. Mohanty Bontha V. Babu |
| author_sort | Anil Purohit |
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| description | Abstract Background & objectives Sickle Cell Disease (SCD), a genetic condition, carries significant public health implications due to its impact on mortality, morbidity and quality of life. SCD is prevalent among tribal communities. The objective of this study was to conduct a screening of the tribal population and report the prevalence of SCD in southern Rajasthan, India. Methods A cross-sectional study was conducted in two blocks of southern Rajasthan to determine the prevalence of Sickle Cell Trait (SCT) and SCD. The study population underwent screening for SCD initially using the solubility test method. Family members of individuals tested positive for the solubility test were also screened. Subsequently, blood samples were collected from individuals who were positive for the solubility test. The confirmation of SCT and SCD was carried out through HPLC. Results The prevalence of SCT and SCD was 9.87% and 0.32%, respectively. The highest combined prevalence (including SCT and SCD) of 15.52% was observed among the Garasiya tribe, followed by the Bhil tribe with the prevalence of 9.68%. Conclusion SCD is moderately prevalent, with less than a per cent among the tribal population of Southern Rajasthan. However, the prevalence of SCT is about 10%. The study also highlights the feasibility of implementing a population-based screening program. This program can be readily implemented within tribal habitations as a component of the proposed national SCD program. |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-73247036b36b4b45a2d459020fbf07cd2025-01-19T12:21:04ZengNature PortfolioScientific Reports2045-23222025-01-011511510.1038/s41598-024-81224-1Epidemiology of sickle cell disease in tribal population of Southern Rajasthan, IndiaAnil Purohit0Ramesh K. Huda1Suman S. Mohanty2Bontha V. Babu3Indian Council of Medical Research-National Institute for Implementation Research on Non- Communicable DiseasesIndian Council of Medical Research-National Institute for Implementation Research on Non- Communicable DiseasesIndian Council of Medical Research-National Institute for Implementation Research on Non- Communicable DiseasesIndian Council of Medical Research-National Institute for Implementation Research on Non- Communicable DiseasesAbstract Background & objectives Sickle Cell Disease (SCD), a genetic condition, carries significant public health implications due to its impact on mortality, morbidity and quality of life. SCD is prevalent among tribal communities. The objective of this study was to conduct a screening of the tribal population and report the prevalence of SCD in southern Rajasthan, India. Methods A cross-sectional study was conducted in two blocks of southern Rajasthan to determine the prevalence of Sickle Cell Trait (SCT) and SCD. The study population underwent screening for SCD initially using the solubility test method. Family members of individuals tested positive for the solubility test were also screened. Subsequently, blood samples were collected from individuals who were positive for the solubility test. The confirmation of SCT and SCD was carried out through HPLC. Results The prevalence of SCT and SCD was 9.87% and 0.32%, respectively. The highest combined prevalence (including SCT and SCD) of 15.52% was observed among the Garasiya tribe, followed by the Bhil tribe with the prevalence of 9.68%. Conclusion SCD is moderately prevalent, with less than a per cent among the tribal population of Southern Rajasthan. However, the prevalence of SCT is about 10%. The study also highlights the feasibility of implementing a population-based screening program. This program can be readily implemented within tribal habitations as a component of the proposed national SCD program.https://doi.org/10.1038/s41598-024-81224-1Sickle cell disease (SCD)Sickle cell trait (SCT)HbS geneEpidemiology |
| spellingShingle | Anil Purohit Ramesh K. Huda Suman S. Mohanty Bontha V. Babu Epidemiology of sickle cell disease in tribal population of Southern Rajasthan, India Scientific Reports Sickle cell disease (SCD) Sickle cell trait (SCT) HbS gene Epidemiology |
| title | Epidemiology of sickle cell disease in tribal population of Southern Rajasthan, India |
| title_full | Epidemiology of sickle cell disease in tribal population of Southern Rajasthan, India |
| title_fullStr | Epidemiology of sickle cell disease in tribal population of Southern Rajasthan, India |
| title_full_unstemmed | Epidemiology of sickle cell disease in tribal population of Southern Rajasthan, India |
| title_short | Epidemiology of sickle cell disease in tribal population of Southern Rajasthan, India |
| title_sort | epidemiology of sickle cell disease in tribal population of southern rajasthan india |
| topic | Sickle cell disease (SCD) Sickle cell trait (SCT) HbS gene Epidemiology |
| url | https://doi.org/10.1038/s41598-024-81224-1 |
| work_keys_str_mv | AT anilpurohit epidemiologyofsicklecelldiseaseintribalpopulationofsouthernrajasthanindia AT rameshkhuda epidemiologyofsicklecelldiseaseintribalpopulationofsouthernrajasthanindia AT sumansmohanty epidemiologyofsicklecelldiseaseintribalpopulationofsouthernrajasthanindia AT bonthavbabu epidemiologyofsicklecelldiseaseintribalpopulationofsouthernrajasthanindia |