Proteomics of the temporal cortex in semantic dementia reveals brain-region specific molecular pathology and regulation of the TDP-43-ANXA11 interactome

Proteomics of the temporal cortex in semantic dementia reveals brain-region specific molecular pathology and regulation of the TDP-43-ANXA11 interactome

Abstract Semantic dementia (SD) is a clinical subtype of frontotemporal dementia characterized by impaired word comprehension and semantic memory, and occurs nearly always sporadically. Neuroimaging typically reveals asymmetric, predominantly left-sided, atrophy of the anterior temporal pole, anteri...

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Main Authors: Suzanne S. M. Miedema, Ana Rajicic, Merel O. Mol, Iryna Paliukhovich, Remco V. Klaassen, Renee van Buuren, Ka Wan Li, Frank T. W. Koopmans, Harro Seelaar, Jeroen G. J. van Rooij, August B. Smit, John C. van Swieten
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Acta Neuropathologica Communications
Subjects:
Semantic dementia
FTLD-TDP type C
Temporal cortex
Quantitative proteomics
RNP complex
Presynaptic regulation calcium levels
Online Access:https://doi.org/10.1186/s40478-025-02077-x
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