Oscillatory ventilation enhances oxygenation and reduces inflammation in an animal model of acute respiratory distress syndrome: an experimental study
Background: This study aims to compare the use of variable mechanical ventilation with conventional mechanical ventilation in a porcine model of ARDS induced by oleic acid. Methods: The animals were divided into two groups (n = 6), Conventional Ventilation (CO) and variable ventilation with Bi-Oscil...
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Elsevier
2025-01-01
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| Series: | Brazilian Journal of Anesthesiology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0104001424000988 |
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| author | Luiz Alberto Forgiarini Junior Luiz Felipe Forgiarini Arthur de Oliveira Paludo Rodrigo Mariano Mikael Marcelo de Moraes Elaine Aparecida Felix Cristiano Feijó Andrade |
| author_facet | Luiz Alberto Forgiarini Junior Luiz Felipe Forgiarini Arthur de Oliveira Paludo Rodrigo Mariano Mikael Marcelo de Moraes Elaine Aparecida Felix Cristiano Feijó Andrade |
| author_sort | Luiz Alberto Forgiarini Junior |
| collection | DOAJ |
| description | Background: This study aims to compare the use of variable mechanical ventilation with conventional mechanical ventilation in a porcine model of ARDS induced by oleic acid. Methods: The animals were divided into two groups (n = 6), Conventional Ventilation (CO) and variable ventilation with Bi-Oscillatory PEEP (BiPEEP). ARDS was induced using intravenous oleic acid (0.15 mL.kg−1). After, the animals were evaluated during 180 minutes and, measurements were taken every 30 minutes until the end of the observation period. The animals in the CO group were then ventilated under controlled pressure (Tidal Volume target at 6 mL.kg−1) and 5 cm H2O PEEP. Variable ventilation was characterized by the oscillation of PEEP from 5 to 10 cm H2O every 4 respiratory cycles. Ventilatory, hemodynamic parameters, oxidative stress, antioxidant enzymes, Interleukin 8 (IL8) and 17-a (IL17a) were evaluated. Histological samples were collected from the upper and the lower portion of the left lungs and analyzed separately. Results: BiPEEP improved lung compliance and PaO2 in comparison to control (p < 0.05). The levels of oxidative stress and antioxidant enzymes showed no significant difference. There was no difference in IL17a between groups. IL8 was significantly increased in the lung base of CO group in relation to BiPEEP group and it was reduced in the apex of BiPEEP group in comparsion to CO group. The BiPEEP group showed less changes in histopathological patterns. Conclusion: Variable ventilation with bi-oscillatory level of PEEP demonstrated a potential ventilatory strategy for lung protection in an experimental model of ARDS. |
| format | Article |
| id | doaj-art-7317011ee9c54453b830eb6b4c8ff323 |
| institution | Kabale University |
| issn | 0104-0014 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Anesthesiology |
| spelling | doaj-art-7317011ee9c54453b830eb6b4c8ff3232025-02-01T04:11:32ZengElsevierBrazilian Journal of Anesthesiology0104-00142025-01-01751844576Oscillatory ventilation enhances oxygenation and reduces inflammation in an animal model of acute respiratory distress syndrome: an experimental studyLuiz Alberto Forgiarini Junior0Luiz Felipe Forgiarini1Arthur de Oliveira Paludo2Rodrigo Mariano3Mikael Marcelo de Moraes4Elaine Aparecida Felix5Cristiano Feijó Andrade6Universidade Católica de Pelotas (UCPel), Pelotas, RS, Brasil; Corresponding author.Centro Universitário Ritter dos Reis (Uniritter), Porto Alegre, RS, Brasil; Universidade Federal do Rio Grande do Sul (UFRGS), Faculdade de Medicina, Programa de Pós-Graduação em Ciências Pneumológicas, Porto Alegre, RS, BrasilHospital de Clinicas de Porto Alegre (HCPA), Porto Alegre, RS, BrasilHospital de Clinicas de Porto Alegre (HCPA), Porto Alegre, RS, BrasilHospital de Clinicas de Porto Alegre (HCPA), Porto Alegre, RS, BrasilHospital de Clinicas de Porto Alegre (HCPA), Porto Alegre, RS, BrasilUniversidade Federal do Rio Grande do Sul (UFRGS), Faculdade de Medicina, Programa de Pós-Graduação em Ciências Pneumológicas, Porto Alegre, RS, Brasil; Hospital de Clinicas de Porto Alegre (HCPA), Porto Alegre, RS, BrasilBackground: This study aims to compare the use of variable mechanical ventilation with conventional mechanical ventilation in a porcine model of ARDS induced by oleic acid. Methods: The animals were divided into two groups (n = 6), Conventional Ventilation (CO) and variable ventilation with Bi-Oscillatory PEEP (BiPEEP). ARDS was induced using intravenous oleic acid (0.15 mL.kg−1). After, the animals were evaluated during 180 minutes and, measurements were taken every 30 minutes until the end of the observation period. The animals in the CO group were then ventilated under controlled pressure (Tidal Volume target at 6 mL.kg−1) and 5 cm H2O PEEP. Variable ventilation was characterized by the oscillation of PEEP from 5 to 10 cm H2O every 4 respiratory cycles. Ventilatory, hemodynamic parameters, oxidative stress, antioxidant enzymes, Interleukin 8 (IL8) and 17-a (IL17a) were evaluated. Histological samples were collected from the upper and the lower portion of the left lungs and analyzed separately. Results: BiPEEP improved lung compliance and PaO2 in comparison to control (p < 0.05). The levels of oxidative stress and antioxidant enzymes showed no significant difference. There was no difference in IL17a between groups. IL8 was significantly increased in the lung base of CO group in relation to BiPEEP group and it was reduced in the apex of BiPEEP group in comparsion to CO group. The BiPEEP group showed less changes in histopathological patterns. Conclusion: Variable ventilation with bi-oscillatory level of PEEP demonstrated a potential ventilatory strategy for lung protection in an experimental model of ARDS.http://www.sciencedirect.com/science/article/pii/S0104001424000988Acute respiratory distress syndromeMechanical ventilationPositive-pressure respiration |
| spellingShingle | Luiz Alberto Forgiarini Junior Luiz Felipe Forgiarini Arthur de Oliveira Paludo Rodrigo Mariano Mikael Marcelo de Moraes Elaine Aparecida Felix Cristiano Feijó Andrade Oscillatory ventilation enhances oxygenation and reduces inflammation in an animal model of acute respiratory distress syndrome: an experimental study Brazilian Journal of Anesthesiology Acute respiratory distress syndrome Mechanical ventilation Positive-pressure respiration |
| title | Oscillatory ventilation enhances oxygenation and reduces inflammation in an animal model of acute respiratory distress syndrome: an experimental study |
| title_full | Oscillatory ventilation enhances oxygenation and reduces inflammation in an animal model of acute respiratory distress syndrome: an experimental study |
| title_fullStr | Oscillatory ventilation enhances oxygenation and reduces inflammation in an animal model of acute respiratory distress syndrome: an experimental study |
| title_full_unstemmed | Oscillatory ventilation enhances oxygenation and reduces inflammation in an animal model of acute respiratory distress syndrome: an experimental study |
| title_short | Oscillatory ventilation enhances oxygenation and reduces inflammation in an animal model of acute respiratory distress syndrome: an experimental study |
| title_sort | oscillatory ventilation enhances oxygenation and reduces inflammation in an animal model of acute respiratory distress syndrome an experimental study |
| topic | Acute respiratory distress syndrome Mechanical ventilation Positive-pressure respiration |
| url | http://www.sciencedirect.com/science/article/pii/S0104001424000988 |
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