Physiologically Based Structure of Mean Residence Time
A mean residence time (MRT) is an important pharmacokinetic parameter. To the author's knowledge, however, a physiologically based structure of MRT (thereafter MRT structure) has not been published so far. Primarily this is because MRT structures cannot be identified by traditional pharmacokine...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/610631 |
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| _version_ | 1832560392377729024 |
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| author | Mária Durišová |
| author_facet | Mária Durišová |
| author_sort | Mária Durišová |
| collection | DOAJ |
| description | A mean residence time (MRT) is an important pharmacokinetic parameter. To the author's knowledge, however, a physiologically based structure of MRT (thereafter MRT structure) has not been published so far. Primarily this is because MRT structures cannot be identified by traditional pharmacokinetic methods used for the determination of MRT. Therefore, tools from the theory of linear dynamic systems were used for the structural identification of MRT in this study. The MRT structure identified is physiologically meaningful. Accordingly, it seems that the MRT structure identified may contribute to already established knowledge about MRT. |
| format | Article |
| id | doaj-art-730864d997bb4b7ab61e8314c425846b |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-730864d997bb4b7ab61e8314c425846b2025-02-03T01:27:41ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/610631610631Physiologically Based Structure of Mean Residence TimeMária Durišová0The Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, 84104 Bratislava, SlovakiaA mean residence time (MRT) is an important pharmacokinetic parameter. To the author's knowledge, however, a physiologically based structure of MRT (thereafter MRT structure) has not been published so far. Primarily this is because MRT structures cannot be identified by traditional pharmacokinetic methods used for the determination of MRT. Therefore, tools from the theory of linear dynamic systems were used for the structural identification of MRT in this study. The MRT structure identified is physiologically meaningful. Accordingly, it seems that the MRT structure identified may contribute to already established knowledge about MRT.http://dx.doi.org/10.1100/2012/610631 |
| spellingShingle | Mária Durišová Physiologically Based Structure of Mean Residence Time The Scientific World Journal |
| title | Physiologically Based Structure of Mean Residence Time |
| title_full | Physiologically Based Structure of Mean Residence Time |
| title_fullStr | Physiologically Based Structure of Mean Residence Time |
| title_full_unstemmed | Physiologically Based Structure of Mean Residence Time |
| title_short | Physiologically Based Structure of Mean Residence Time |
| title_sort | physiologically based structure of mean residence time |
| url | http://dx.doi.org/10.1100/2012/610631 |
| work_keys_str_mv | AT mariadurisova physiologicallybasedstructureofmeanresidencetime |