Pathogenesis of Chronic Urticaria: An Overview
The pathogenesis of chronic urticaria is not well delineated and the treatment is palliative as it is not tied to the pathomechanism. The centrality of mast cells and their inappropriate activation and degranulation as the key pathophysiological event are well established. The triggering stimuli and...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2014/674709 |
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| author | Sanjiv Jain |
| author_facet | Sanjiv Jain |
| author_sort | Sanjiv Jain |
| collection | DOAJ |
| description | The pathogenesis of chronic urticaria is not well delineated and the treatment is palliative as it is not tied to the pathomechanism. The centrality of mast cells and their inappropriate activation and degranulation as the key pathophysiological event are well established. The triggering stimuli and the complexity of effector mechanisms remain speculative. Autoimmune origin of chronic urticaria, albeit controversial, is well documented. Numerical and behavioral alterations in basophils accompanied by changes in signaling molecule expression and function as well as aberrant activation of extrinsic pathway of coagulation are other alternative hypotheses. It is also probable that mast cells are involved in the pathogenesis through mechanisms that extend beyond high affinity IgE receptor stimulation. An increasing recognition of chronic urticaria as an immune mediated inflammatory disorder related to altered cytokine-chemokine network consequent to immune dysregulation resulting from disturbed innate immunity is emerging as yet another pathogenic explanation. It is likely that these different pathomechanisms are interlinked rather than independent cascades, acting either synergistically or sequentially to produce clinical expression of chronic urticaria. Insights into the complexities of pathogenesis may provide an impetus to develop safer, efficacious, and targeted immunomodulators and biological treatment for severe, refractory chronic urticaria. |
| format | Article |
| id | doaj-art-72f326b70a234fee9f6f812e78520a15 |
| institution | Kabale University |
| issn | 1687-6105 1687-6113 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Dermatology Research and Practice |
| spelling | doaj-art-72f326b70a234fee9f6f812e78520a152025-02-03T01:23:58ZengWileyDermatology Research and Practice1687-61051687-61132014-01-01201410.1155/2014/674709674709Pathogenesis of Chronic Urticaria: An OverviewSanjiv Jain0Skin Care Clinic, 108 Darya Ganj, New Delhi 110002, IndiaThe pathogenesis of chronic urticaria is not well delineated and the treatment is palliative as it is not tied to the pathomechanism. The centrality of mast cells and their inappropriate activation and degranulation as the key pathophysiological event are well established. The triggering stimuli and the complexity of effector mechanisms remain speculative. Autoimmune origin of chronic urticaria, albeit controversial, is well documented. Numerical and behavioral alterations in basophils accompanied by changes in signaling molecule expression and function as well as aberrant activation of extrinsic pathway of coagulation are other alternative hypotheses. It is also probable that mast cells are involved in the pathogenesis through mechanisms that extend beyond high affinity IgE receptor stimulation. An increasing recognition of chronic urticaria as an immune mediated inflammatory disorder related to altered cytokine-chemokine network consequent to immune dysregulation resulting from disturbed innate immunity is emerging as yet another pathogenic explanation. It is likely that these different pathomechanisms are interlinked rather than independent cascades, acting either synergistically or sequentially to produce clinical expression of chronic urticaria. Insights into the complexities of pathogenesis may provide an impetus to develop safer, efficacious, and targeted immunomodulators and biological treatment for severe, refractory chronic urticaria.http://dx.doi.org/10.1155/2014/674709 |
| spellingShingle | Sanjiv Jain Pathogenesis of Chronic Urticaria: An Overview Dermatology Research and Practice |
| title | Pathogenesis of Chronic Urticaria: An Overview |
| title_full | Pathogenesis of Chronic Urticaria: An Overview |
| title_fullStr | Pathogenesis of Chronic Urticaria: An Overview |
| title_full_unstemmed | Pathogenesis of Chronic Urticaria: An Overview |
| title_short | Pathogenesis of Chronic Urticaria: An Overview |
| title_sort | pathogenesis of chronic urticaria an overview |
| url | http://dx.doi.org/10.1155/2014/674709 |
| work_keys_str_mv | AT sanjivjain pathogenesisofchronicurticariaanoverview |