Ketogenic diet and β-hydroxybutyrate in osteoporosis: current progress and controversy
Diet has been proven to have significant impacts on the pathogenesis and treatment of osteoporosis. This review attempts to elucidate the current progress and controversy surrounding the ketogenic diet (KD) and β-hydroxybutyrate (BHB) in osteoporosis and offers a novel perspective on the prevention...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1508695/full |
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| author | Changfang Luo Changfang Luo Changfang Luo Changfang Luo Zhuojun Dai Zhuojun Dai Zhuojun Dai Zhuojun Dai Wanhong He Wanhong He Wanhong He Wanhong He Yanqiu He Yanqiu He Yanqiu He Yanqiu He Ping Yang Ping Yang Ping Yang Ping Yang Mengting Huang Mengting Huang Mengting Huang Mengting Huang Junle Li Junle Li Junle Li Junle Li Yong Xu Yong Xu Yong Xu Yong Xu Wei Huang Wei Huang Wei Huang Wei Huang |
| author_facet | Changfang Luo Changfang Luo Changfang Luo Changfang Luo Zhuojun Dai Zhuojun Dai Zhuojun Dai Zhuojun Dai Wanhong He Wanhong He Wanhong He Wanhong He Yanqiu He Yanqiu He Yanqiu He Yanqiu He Ping Yang Ping Yang Ping Yang Ping Yang Mengting Huang Mengting Huang Mengting Huang Mengting Huang Junle Li Junle Li Junle Li Junle Li Yong Xu Yong Xu Yong Xu Yong Xu Wei Huang Wei Huang Wei Huang Wei Huang |
| author_sort | Changfang Luo |
| collection | DOAJ |
| description | Diet has been proven to have significant impacts on the pathogenesis and treatment of osteoporosis. This review attempts to elucidate the current progress and controversy surrounding the ketogenic diet (KD) and β-hydroxybutyrate (BHB) in osteoporosis and offers a novel perspective on the prevention and treatment of osteoporosis. The ketogenic diet has been broadly used in the treatment of epilepsy, diabetes, obesity, and certain neoplasms by triggering ketone bodies, mainly BHB. However, in most osteoporosis-related clinical and preclinical studies, the ketogenic diet has demonstrated the detrimental effects of inhibiting bone accumulation and damaging bone microarchitecture. In contrast, BHB is thought to ameliorate osteoporosis by promoting osteoblastogenesis and inhibiting osteoclastogenesis. The main purpose of this review is to summarize the current research progress and hope that more basic and clinical experiments will focus on the similarities and differences between ketogenic diet (KD) and BHB in osteoporosis. |
| format | Article |
| id | doaj-art-72f108c6b1d74c428164a463bfb2f12b |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-72f108c6b1d74c428164a463bfb2f12b2025-01-23T05:10:16ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-01-011210.3389/fnut.2025.15086951508695Ketogenic diet and β-hydroxybutyrate in osteoporosis: current progress and controversyChangfang Luo0Changfang Luo1Changfang Luo2Changfang Luo3Zhuojun Dai4Zhuojun Dai5Zhuojun Dai6Zhuojun Dai7Wanhong He8Wanhong He9Wanhong He10Wanhong He11Yanqiu He12Yanqiu He13Yanqiu He14Yanqiu He15Ping Yang16Ping Yang17Ping Yang18Ping Yang19Mengting Huang20Mengting Huang21Mengting Huang22Mengting Huang23Junle Li24Junle Li25Junle Li26Junle Li27Yong Xu28Yong Xu29Yong Xu30Yong Xu31Wei Huang32Wei Huang33Wei Huang34Wei Huang35Department of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaMetabolic Vascular Diseases Key Laboratory of Sichuan Province, Luzhou, Sichuan, ChinaSichuan Clinical Research Center for Nephropathy, Luzhou, Sichuan, ChinaSichuan Clinical Research Center for Diabetes and Metabolic Diseases, Luzhou, Sichuan, ChinaDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaMetabolic Vascular Diseases Key Laboratory of Sichuan Province, Luzhou, Sichuan, ChinaSichuan Clinical Research Center for Nephropathy, Luzhou, Sichuan, ChinaSichuan Clinical Research Center for Diabetes and Metabolic Diseases, Luzhou, Sichuan, ChinaDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaMetabolic Vascular Diseases Key Laboratory of Sichuan Province, Luzhou, Sichuan, ChinaSichuan Clinical Research Center for Nephropathy, Luzhou, Sichuan, ChinaSichuan Clinical Research Center for Diabetes and Metabolic Diseases, Luzhou, Sichuan, ChinaDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaMetabolic Vascular Diseases Key Laboratory of Sichuan Province, Luzhou, Sichuan, ChinaSichuan Clinical Research Center for Nephropathy, Luzhou, Sichuan, ChinaSichuan Clinical Research Center for Diabetes and Metabolic Diseases, Luzhou, Sichuan, ChinaDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaMetabolic Vascular Diseases Key Laboratory of Sichuan Province, Luzhou, Sichuan, ChinaSichuan Clinical Research Center for Nephropathy, Luzhou, Sichuan, ChinaSichuan Clinical Research Center for Diabetes and Metabolic Diseases, Luzhou, Sichuan, ChinaDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaMetabolic Vascular Diseases Key Laboratory of Sichuan Province, Luzhou, Sichuan, ChinaSichuan Clinical Research Center for Nephropathy, Luzhou, Sichuan, ChinaSichuan Clinical Research Center for Diabetes and Metabolic Diseases, Luzhou, Sichuan, ChinaDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaMetabolic Vascular Diseases Key Laboratory of Sichuan Province, Luzhou, Sichuan, ChinaSichuan Clinical Research Center for Nephropathy, Luzhou, Sichuan, ChinaSichuan Clinical Research Center for Diabetes and Metabolic Diseases, Luzhou, Sichuan, ChinaDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaMetabolic Vascular Diseases Key Laboratory of Sichuan Province, Luzhou, Sichuan, ChinaSichuan Clinical Research Center for Nephropathy, Luzhou, Sichuan, ChinaSichuan Clinical Research Center for Diabetes and Metabolic Diseases, Luzhou, Sichuan, ChinaDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaMetabolic Vascular Diseases Key Laboratory of Sichuan Province, Luzhou, Sichuan, ChinaSichuan Clinical Research Center for Nephropathy, Luzhou, Sichuan, ChinaSichuan Clinical Research Center for Diabetes and Metabolic Diseases, Luzhou, Sichuan, ChinaDiet has been proven to have significant impacts on the pathogenesis and treatment of osteoporosis. This review attempts to elucidate the current progress and controversy surrounding the ketogenic diet (KD) and β-hydroxybutyrate (BHB) in osteoporosis and offers a novel perspective on the prevention and treatment of osteoporosis. The ketogenic diet has been broadly used in the treatment of epilepsy, diabetes, obesity, and certain neoplasms by triggering ketone bodies, mainly BHB. However, in most osteoporosis-related clinical and preclinical studies, the ketogenic diet has demonstrated the detrimental effects of inhibiting bone accumulation and damaging bone microarchitecture. In contrast, BHB is thought to ameliorate osteoporosis by promoting osteoblastogenesis and inhibiting osteoclastogenesis. The main purpose of this review is to summarize the current research progress and hope that more basic and clinical experiments will focus on the similarities and differences between ketogenic diet (KD) and BHB in osteoporosis.https://www.frontiersin.org/articles/10.3389/fnut.2025.1508695/fullketogenic dietβ-hydroxybutyrateosteoporosisosteoblastosteoclast |
| spellingShingle | Changfang Luo Changfang Luo Changfang Luo Changfang Luo Zhuojun Dai Zhuojun Dai Zhuojun Dai Zhuojun Dai Wanhong He Wanhong He Wanhong He Wanhong He Yanqiu He Yanqiu He Yanqiu He Yanqiu He Ping Yang Ping Yang Ping Yang Ping Yang Mengting Huang Mengting Huang Mengting Huang Mengting Huang Junle Li Junle Li Junle Li Junle Li Yong Xu Yong Xu Yong Xu Yong Xu Wei Huang Wei Huang Wei Huang Wei Huang Ketogenic diet and β-hydroxybutyrate in osteoporosis: current progress and controversy Frontiers in Nutrition ketogenic diet β-hydroxybutyrate osteoporosis osteoblast osteoclast |
| title | Ketogenic diet and β-hydroxybutyrate in osteoporosis: current progress and controversy |
| title_full | Ketogenic diet and β-hydroxybutyrate in osteoporosis: current progress and controversy |
| title_fullStr | Ketogenic diet and β-hydroxybutyrate in osteoporosis: current progress and controversy |
| title_full_unstemmed | Ketogenic diet and β-hydroxybutyrate in osteoporosis: current progress and controversy |
| title_short | Ketogenic diet and β-hydroxybutyrate in osteoporosis: current progress and controversy |
| title_sort | ketogenic diet and β hydroxybutyrate in osteoporosis current progress and controversy |
| topic | ketogenic diet β-hydroxybutyrate osteoporosis osteoblast osteoclast |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1508695/full |
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