eIF3 engages with 3’-UTR termini of highly translated mRNAs

eIF3 engages with 3’-UTR termini of highly translated mRNAs

Stem cell differentiation involves a global increase in protein synthesis to meet the demands of specialized cell types. However, the molecular mechanisms underlying this translational burst and the involvement of initiation factors remains largely unknown. Here, we investigate the role of eukaryoti...

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Bibliographic Details
Main Authors: Santi Mestre-Fos, Lucas Ferguson, Marena I Trinidad, Nicholas T Ingolia, Jamie HD Cate
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-01-01
Series:eLife
Subjects:
eIF3
protein synthesis
3'-UTR
quick-irCLIP
ribosome profiling
Online Access:https://elifesciences.org/articles/102977
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