Molecular Origami: Designing Functional Molecules of the Future
In the field of chemical biology, DNA origami has been actively researched. This technique, which involves folding DNA strands like origami to assemble them into desired shapes, has made it possible to create complex nanometer-sized structures, marking a major breakthrough in nanotechnology. On the...
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MDPI AG
2025-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/30/2/242 |
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| author | Hitoshi Ishida Takeshi Ito Akinori Kuzuya |
| author_facet | Hitoshi Ishida Takeshi Ito Akinori Kuzuya |
| author_sort | Hitoshi Ishida |
| collection | DOAJ |
| description | In the field of chemical biology, DNA origami has been actively researched. This technique, which involves folding DNA strands like origami to assemble them into desired shapes, has made it possible to create complex nanometer-sized structures, marking a major breakthrough in nanotechnology. On the other hand, controlling the folding mechanisms and folded structures of proteins or shorter peptides has been challenging. However, recent advances in techniques such as protein origami, peptide origami, and de novo design peptides have made it possible to construct various nanoscale structures and create functional molecules. These approaches suggest the emergence of new molecular design principles, which can be termed “molecular origami”. In this review, we provide an overview of recent research trends in protein/peptide origami and DNA/RNA origami and explore potential future applications of molecular origami technologies in electrochemical biosensors. |
| format | Article |
| id | doaj-art-72ec519a323f4c2b8a6e8ee0cbd388b2 |
| institution | Kabale University |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-72ec519a323f4c2b8a6e8ee0cbd388b22025-01-24T13:43:13ZengMDPI AGMolecules1420-30492025-01-0130224210.3390/molecules30020242Molecular Origami: Designing Functional Molecules of the FutureHitoshi Ishida0Takeshi Ito1Akinori Kuzuya2Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, Kansai University, 3-3-35 Yamate-cho, Suita 564-8680, Osaka, JapanGraduate School of Science and Engineering, Kansai University, 3-3-35 Yamate-cho, Suita 564-8680, Osaka, JapanDepartment of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, Kansai University, 3-3-35 Yamate-cho, Suita 564-8680, Osaka, JapanIn the field of chemical biology, DNA origami has been actively researched. This technique, which involves folding DNA strands like origami to assemble them into desired shapes, has made it possible to create complex nanometer-sized structures, marking a major breakthrough in nanotechnology. On the other hand, controlling the folding mechanisms and folded structures of proteins or shorter peptides has been challenging. However, recent advances in techniques such as protein origami, peptide origami, and de novo design peptides have made it possible to construct various nanoscale structures and create functional molecules. These approaches suggest the emergence of new molecular design principles, which can be termed “molecular origami”. In this review, we provide an overview of recent research trends in protein/peptide origami and DNA/RNA origami and explore potential future applications of molecular origami technologies in electrochemical biosensors.https://www.mdpi.com/1420-3049/30/2/242molecular origamiprotein origamipeptide origamiDNA origamibiosensor |
| spellingShingle | Hitoshi Ishida Takeshi Ito Akinori Kuzuya Molecular Origami: Designing Functional Molecules of the Future Molecules molecular origami protein origami peptide origami DNA origami biosensor |
| title | Molecular Origami: Designing Functional Molecules of the Future |
| title_full | Molecular Origami: Designing Functional Molecules of the Future |
| title_fullStr | Molecular Origami: Designing Functional Molecules of the Future |
| title_full_unstemmed | Molecular Origami: Designing Functional Molecules of the Future |
| title_short | Molecular Origami: Designing Functional Molecules of the Future |
| title_sort | molecular origami designing functional molecules of the future |
| topic | molecular origami protein origami peptide origami DNA origami biosensor |
| url | https://www.mdpi.com/1420-3049/30/2/242 |
| work_keys_str_mv | AT hitoshiishida molecularorigamidesigningfunctionalmoleculesofthefuture AT takeshiito molecularorigamidesigningfunctionalmoleculesofthefuture AT akinorikuzuya molecularorigamidesigningfunctionalmoleculesofthefuture |