Beta-Thalassemia in Iran: New Insight into the Role of Genetic Admixture and Migration
Iran with an area of 1.648 million km2 is located between the Caspian Sea and the Persian Gulf. The Iranian population consists of multiethnic groups that have been influenced by various invasions and migration throughout history. Studies have revealed the presence of more than 47 different β-globin...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/635183 |
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| author | Ali Reza Rezaee Mohammad Mehdi Banoei Elham Khalili Massoud Houshmand |
| author_facet | Ali Reza Rezaee Mohammad Mehdi Banoei Elham Khalili Massoud Houshmand |
| author_sort | Ali Reza Rezaee |
| collection | DOAJ |
| description | Iran with an area of 1.648 million km2 is located between the Caspian Sea and the Persian Gulf. The Iranian population consists of multiethnic groups that have been influenced by various invasions and migration throughout history. Studies have revealed the presence of more than 47 different β-globin gene mutations responsible for β-Thalassemia in Iran. This paper is an attempt to study the origin of β-Thalassemia mutations in different parts of Iran. Distribution of β-Thalassemia mutations in Iran shows different patterns in different areas. β-Thalassemia mutations have been a reflection of people and area in correlation with migration and origin of ancestors. We compared the frequencies of β-globin mutations in different regions of Iran with those derived from neighboring countries. The analysis provided evidence of complementary information about the genetic admixture and migration of some mutations, as well as the remarkable genetic classification of the Iranian people and ethnic groups. |
| format | Article |
| id | doaj-art-72e51e6331424820867d85681a20b4b5 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-72e51e6331424820867d85681a20b4b52025-02-03T01:33:23ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/635183635183Beta-Thalassemia in Iran: New Insight into the Role of Genetic Admixture and MigrationAli Reza Rezaee0Mohammad Mehdi Banoei1Elham Khalili2Massoud Houshmand3Department of Animal Science, Faculty of Agriculture, Ferdowsi University of Mashhad, Mashhad, IranDepartment of Medical Genetics, National Institute of Genetic Engineering and Biotechnology, Tehran 14155-6343, IranDepartment of Genetics, Special Medical Center, Tehran, IranDepartment of Medical Genetics, National Institute of Genetic Engineering and Biotechnology, Tehran 14155-6343, IranIran with an area of 1.648 million km2 is located between the Caspian Sea and the Persian Gulf. The Iranian population consists of multiethnic groups that have been influenced by various invasions and migration throughout history. Studies have revealed the presence of more than 47 different β-globin gene mutations responsible for β-Thalassemia in Iran. This paper is an attempt to study the origin of β-Thalassemia mutations in different parts of Iran. Distribution of β-Thalassemia mutations in Iran shows different patterns in different areas. β-Thalassemia mutations have been a reflection of people and area in correlation with migration and origin of ancestors. We compared the frequencies of β-globin mutations in different regions of Iran with those derived from neighboring countries. The analysis provided evidence of complementary information about the genetic admixture and migration of some mutations, as well as the remarkable genetic classification of the Iranian people and ethnic groups.http://dx.doi.org/10.1100/2012/635183 |
| spellingShingle | Ali Reza Rezaee Mohammad Mehdi Banoei Elham Khalili Massoud Houshmand Beta-Thalassemia in Iran: New Insight into the Role of Genetic Admixture and Migration The Scientific World Journal |
| title | Beta-Thalassemia in Iran: New Insight into the Role of Genetic Admixture and Migration |
| title_full | Beta-Thalassemia in Iran: New Insight into the Role of Genetic Admixture and Migration |
| title_fullStr | Beta-Thalassemia in Iran: New Insight into the Role of Genetic Admixture and Migration |
| title_full_unstemmed | Beta-Thalassemia in Iran: New Insight into the Role of Genetic Admixture and Migration |
| title_short | Beta-Thalassemia in Iran: New Insight into the Role of Genetic Admixture and Migration |
| title_sort | beta thalassemia in iran new insight into the role of genetic admixture and migration |
| url | http://dx.doi.org/10.1100/2012/635183 |
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