Application of Surface Roughness Analysis on Micro–Computed Tomographic Images of Bone Erosion: Examples Using a Rodent Model of Rheumatoid Arthritis
Quantifying the bone erosion in preclinical models of rheumatoid arthritis is valuable for the evaluation of drug treatments. This study introduces a three-dimensional method for bone surface roughness measurement from micro–computed tomographic data obtained from rats subjected to collagen-induced...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2006-10-01
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| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.2310/7290.2006.00025 |
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| _version_ | 1832544619313758208 |
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| author | Matthew D. Silva Jason Ruan Elizabeth Siebert Anneli Savinainen Bruce Jaffee Lisa Schopf Sudeep Chandra |
| author_facet | Matthew D. Silva Jason Ruan Elizabeth Siebert Anneli Savinainen Bruce Jaffee Lisa Schopf Sudeep Chandra |
| author_sort | Matthew D. Silva |
| collection | DOAJ |
| description | Quantifying the bone erosion in preclinical models of rheumatoid arthritis is valuable for the evaluation of drug treatments. This study introduces a three-dimensional method for bone surface roughness measurement from micro–computed tomographic data obtained from rats subjected to collagen-induced arthritis (CIA), in which the degree of bone erosion is related to the severity and the duration of the disease. In two studies of rat CIA, the surface roughness of the talus bone following 21 days of disease increased 559% and 486% from the control group. At 41 days following disease induction, the roughness of the bone surface increased 857% above baseline. The roughness of the control samples was similar from each study (less than 4% different), demonstrating the robustness of the algorithm. Treatment with methotrexate at 0.1 mg/kg daily demonstrated significant protection from bone erosion, whereas the 0.05 mg/kg daily dose was not efficacious (98% versus 22% inhibition of roughness-measured bone erosion). The main advantage of such an algorithm is demonstrated in the preclinical drug study of rat CIA with methotrexate treatment, indicating the immediate utility of this approach in drug development studies. |
| format | Article |
| id | doaj-art-72df5b31a33b4e2797a8f6fdb1c9d585 |
| institution | Kabale University |
| issn | 1536-0121 |
| language | English |
| publishDate | 2006-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj-art-72df5b31a33b4e2797a8f6fdb1c9d5852025-02-03T10:07:51ZengSAGE PublishingMolecular Imaging1536-01212006-10-01510.2310/7290.2006.0002510.2310_7290.2006.00025Application of Surface Roughness Analysis on Micro–Computed Tomographic Images of Bone Erosion: Examples Using a Rodent Model of Rheumatoid ArthritisMatthew D. SilvaJason RuanElizabeth SiebertAnneli SavinainenBruce JaffeeLisa SchopfSudeep ChandraQuantifying the bone erosion in preclinical models of rheumatoid arthritis is valuable for the evaluation of drug treatments. This study introduces a three-dimensional method for bone surface roughness measurement from micro–computed tomographic data obtained from rats subjected to collagen-induced arthritis (CIA), in which the degree of bone erosion is related to the severity and the duration of the disease. In two studies of rat CIA, the surface roughness of the talus bone following 21 days of disease increased 559% and 486% from the control group. At 41 days following disease induction, the roughness of the bone surface increased 857% above baseline. The roughness of the control samples was similar from each study (less than 4% different), demonstrating the robustness of the algorithm. Treatment with methotrexate at 0.1 mg/kg daily demonstrated significant protection from bone erosion, whereas the 0.05 mg/kg daily dose was not efficacious (98% versus 22% inhibition of roughness-measured bone erosion). The main advantage of such an algorithm is demonstrated in the preclinical drug study of rat CIA with methotrexate treatment, indicating the immediate utility of this approach in drug development studies.https://doi.org/10.2310/7290.2006.00025 |
| spellingShingle | Matthew D. Silva Jason Ruan Elizabeth Siebert Anneli Savinainen Bruce Jaffee Lisa Schopf Sudeep Chandra Application of Surface Roughness Analysis on Micro–Computed Tomographic Images of Bone Erosion: Examples Using a Rodent Model of Rheumatoid Arthritis Molecular Imaging |
| title | Application of Surface Roughness Analysis on Micro–Computed Tomographic Images of Bone Erosion: Examples Using a Rodent Model of Rheumatoid Arthritis |
| title_full | Application of Surface Roughness Analysis on Micro–Computed Tomographic Images of Bone Erosion: Examples Using a Rodent Model of Rheumatoid Arthritis |
| title_fullStr | Application of Surface Roughness Analysis on Micro–Computed Tomographic Images of Bone Erosion: Examples Using a Rodent Model of Rheumatoid Arthritis |
| title_full_unstemmed | Application of Surface Roughness Analysis on Micro–Computed Tomographic Images of Bone Erosion: Examples Using a Rodent Model of Rheumatoid Arthritis |
| title_short | Application of Surface Roughness Analysis on Micro–Computed Tomographic Images of Bone Erosion: Examples Using a Rodent Model of Rheumatoid Arthritis |
| title_sort | application of surface roughness analysis on micro computed tomographic images of bone erosion examples using a rodent model of rheumatoid arthritis |
| url | https://doi.org/10.2310/7290.2006.00025 |
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